Microvessel density in prostatic hyperplasia

Foley, S.J.; Bailey, David M.

doi:10.1046/j.1464-410x.2000.00322.x

Cited by 49 publications

(36 citation statements)

References 18 publications

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“…Thus, prostatic blood flow is increased in patients with BPH due to the increased metabolic demands of a larger gland. It has also been found that microvessel density of suburothelial compartments of the prostatic urethra was greater in patients with hematuria related to BPH [9]. Recent studies have demonstrated that finasteride reduces the suburothelial vascularity of the prostatic urethra in humans and the prostatic blood flow in rats, confirming the role of androgens in the regulation of prostatic blood flow and angiogenesis [10,11].…”

Section: Discussionmentioning

confidence: 83%

Finasteride: A Long-Term Follow-Up in the Treatment of Recurrent Hematuria Associated with Benign Prostatic Hyperplasia

Delakas

Lianos²,

Karyotis³

et al. 2001

Urol Int

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Objectives: To assess the effectiveness and long-term results after finasteride treatment of recurrent hematuria associated with benign prostatic hyperplasia (BPH). Materials and Methods: The study comprised 80 patients, aged 62–86 (mean 74) years, of whom 50 received finasteride 5 mg once daily for 4 years and 30 were used as controls. Patients with malignancy, severe hepatic or renal failure and hematologic disorders were excluded. Patients were divided into 3 groups according to the severity of hematuria (minor, moderate, severe). All patients were followed up at 3, 12, 24 and 48 months. Results: The follow-up ranged from 8 to 48 (mean 22) months in the finasteride group and 3–42 (mean 23) months in the control group. Hematuria recurrence rates were 6/50 (12%) and 23/30 (77%) in the finasteride and control groups, respectively. Surgical treatment was needed in 6 patients of the finasteride group and 19 of the control group. Patients with minor hematuria experienced no recurrence of symptoms in the finasteride group in contrast to 13 of 17 patients in the control group. For the patients with moderate hematuria, recurrence of symptoms was observed in 3 of 13 in the finasteride group and 3 of 5 in the control group. Three of six patients with severe hematuria had a recurrence of symptoms after finasteride treatment in contrast to 7 of 8 in the control group. Conclusion: Finasteride has proved to be a safe, well tolerable and effective medication in reducing or preventing recurrent hematuria related to BPH.

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Section: Discussionmentioning

confidence: 83%

Finasteride: A Long-Term Follow-Up in the Treatment of Recurrent Hematuria Associated with Benign Prostatic Hyperplasia

Delakas

Lianos²,

Karyotis³

et al. 2001

Urol Int

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“…Increased vascularity in the prostatic suburothelium in haematuria patients who underwent TURP has been shown. 8 We suspect that, in the patients with vascular prostatic regrowth under discussion here, the prostatic regrowth would show a similar histological increase in microvessel density compared to non-bleeding patients with an equivalent degree of BPH. It would be interesting to compare the histology of prostatic suburothelium from the initial TURP to the bleeding growth to see if there was a predisposition to increased microvascularity or if the TURP altered the histological character of the hyperplastic tissue.…”

Section: Discussionmentioning

confidence: 83%

Haematuria; a late complication of TURP?

Bowden

Foley

2001

Prostate Cancer Prostatic Dis

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This study was designed to investigate the cause of haematuria for patients that had previously undergone a TURP. One hundred patients were identified in a walk-in haematuria clinic as having been treated by TURP and were prospectively investigated for the cause of bleeding. Prostate regrowth was the diagnosis in 63% of cases. A diagnosis of malignancy was made for 23.5% of these patients. We have confirmed the hypothesis that for patients who present with haematuria after a TURP, the prostate is the usual source of bleeding. Prostate Cancer and Prostatic Diseases (2001) 4, 178-179.

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“…Patients with clinical BPH and recurrent gross hematuria have a significantly higher suburethral prostatic microvessel density than patients with BPH alone [9]. BPH associated hematuria is probably related to the increased vascularity of the prostate [6,10].…”

Section: Discussionmentioning

confidence: 96%

“…Treatment options for prostatic bleeding include tamponade of the prostate with a urethral catheter, endoscopic resection and fulguration of the prostate, hormonal ablation, use of antifibrinolytic agents, or careful observation with limiting of physical activity. MVD is a histological measurement of angiogenesis and thus a surrogate marker of bleeding, as the prostates of men with BPH and haematuria have a significantly higher MVD in the suburethral portion than prostates of men with BPH alone [9]. Prostatic microvessel density is a histological and clinical indicator of angiogenesis in patients with BPH.…”

Section: Discussionmentioning

confidence: 99%

Effects of Goserelin Treatment on Microvessel Density and Blood Loss Associated with Transurethral Resection of the Prostat

Kılıç¹

2014

Ann Clin Anal Med

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ÖzetAmaç: Prostat'ın transüretral rezeksiyonundan (TUR-P) önce uygulanan tek doz goserelin' in, benign prostat hiperplazisi (BPH) olan hastalarda kan kaybı ve prostat subüretral dokunun mikrovasküler dansitesi (MVD) üzerine olan etkilerinin belirlenmesi amaçlandı. Gereç ve Yöntem: TUR-P planlanan hastalar iki gruba randomize edilerek ayrıldı. Ameliyattan 1 ay önce 3,6 mg subkütan goserelin asetat uygulanan 18 hasta Grup 1'i oluşturdu. Grup 2 ise goserelin verilmeyen 21 hastadan oluşturuldu. İntraoperatif kanama miktarı ölçüldü.Her hasta için toplam kan kaybı, toplam kan kaybı/ ameliyat süresi, toplam kan kaybı/ rezeke edilen doku gramı hesaplandı. Prostat subüretral doku kesitleri mikrovasküler dansitesi açısından incelendi. Bulgular: Ameliyattan hemen sonra yapılan kontrolde; grup 1'deki hemoglobin (Hb) düşüşü grup 2'ye göre daha fazlaydı ve ortalama Hb seviyesi grup 1'de grup 2'ye kıyasla istatistiksel olarak anlamlı derecede düşük bulundu (p=0.028). İstatistiksel olarak anlamlı olmamasına rağmen irrigasyon sıvısında Hb konsantrasyonu ve ameliyat süresince kan kaybı grup 1'de grup 2'ye oranla daha yüksekti, buna karşılık TUR-P süresine göre ve rezeke edilen prostat doku ağırlığına göre kan kaybı ise grup 1'de grup 2'ye gore daha düşüktü. Mikrovasküler dansite grup 2'de belirgin olarak daha azdı. Tartışma: Bir aylık tek doz goserelin tedavisi, TUR-P boyunca olan kan kaybını azaltmada etkili değildir ve prostat dokusunda mikrovasküler dansitesi üzerinde süpresif etkisi yoktur. Anahtar KelimelerBenign Prostat Hiperplazisi; Goserelin; Mikrovasküler Dansite; Kan Kaybı; Prostatın Transüretral Rezeksiyonu Abstract Aim: To determine the effects of one dose goserelin before transurethral resection of the prostate (TUR-P) on blood loss and microvessel density (MVD) of prostatic suburethral tissues in the patients with benign prostatic hyperplasia (BPH). Material and Method: The patients who planned to have a TUR-P were randomly divided into two groups. Group-1 consisted of 18 patients who were pretreated with 3,6 mgr subcutaneous injection of goserelin acetate one month before the operation. Group-2 was constructed from 21 patients without goserelin acetate pretreatment. The amount of intraoperative haemorrhage was calculated. Total blood loss, total blood loss/duration of surgery and total blood loss/gram of resected tissue were calculated for each patient. Sections from the prostatic suburethral tissues were examined for microvessel density. Results: Quantitative decreases in Hb were greater in group 1 than in group 2, and mean Hb level was statistically significantly lower in group 1 than in group 2 at the control just after the operation (p=0.028). Although all the differences were statistically insignificant, Hb concentration in irrigation fluid and total blood loss during surgery were higher in the group 1 than in the group 2, contrarily, blood loss by duration of TURP and blood loss by weight of resected prostate tissue were less in the group 1 than in the group 2. The MVD was significantly lower in group 2 than ...

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Microvessel density in prostatic hyperplasia

Cited by 49 publications

References 18 publications

Finasteride: A Long-Term Follow-Up in the Treatment of Recurrent Hematuria Associated with Benign Prostatic Hyperplasia

Finasteride: A Long-Term Follow-Up in the Treatment of Recurrent Hematuria Associated with Benign Prostatic Hyperplasia

Haematuria; a late complication of TURP?

Effects of Goserelin Treatment on Microvessel Density and Blood Loss Associated with Transurethral Resection of the Prostat

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