2007
DOI: 10.1111/j.1463-5224.2007.00562.x
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Microvessel loss, vascular damage and glutamate redistribution in the retinas of dogs with primary glaucoma

Abstract: Microvessel loss may occur in regions of glutamate redistribution and neuronal damage in PG retinas. Larger vessels were often damaged. The redistribution of glutamate is associated with a loss of microvessels, even in mildly damaged regions. However, neuronal damage and glutamate redistribution may occur close to remaining microvessels, suggesting microvessel loss was not the sole factor inducing these changes.

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Cited by 18 publications
(30 citation statements)
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“…This redistribution includes increased concentrations of glutamate in Müller cells and decreased concentrations in neurons. We have recently found that microvessel losses are associated with glutamate redistribution and neuronal damage in PG 7 . These results are consistent with microvessel losses leading to local ischemia, glutamate release, and neuronal damage.…”
Section: Introductionsupporting
confidence: 83%
See 1 more Smart Citation
“…This redistribution includes increased concentrations of glutamate in Müller cells and decreased concentrations in neurons. We have recently found that microvessel losses are associated with glutamate redistribution and neuronal damage in PG 7 . These results are consistent with microvessel losses leading to local ischemia, glutamate release, and neuronal damage.…”
Section: Introductionsupporting
confidence: 83%
“…In the current studies we observed decreased GS immunoreactivity in PG retinas that may reflect decreased GS function. We have also reported microvessel losses and vascular damage that may lead to ischemia in canine PG 7 . These two processes may act cooperatively to allow glutamate to accumulate in the extracellular fluid.…”
Section: Discussionmentioning
confidence: 60%
“…Vascular damage in the retina has been associated with glutamate redistribution in dogs with glaucoma. 94 Furthermore, vascular dysregulation leads to ischemia and reperfusion injury, thereby inducing oxidative damage. Oxidative damage has been shown to affect both TM cells and RGCs.…”
Section: Theories and Mechanismsmentioning
confidence: 99%
“…Oxidative stress‐induced changes and microvascular damage occur in retinas of dogs with primary glaucoma. This was demonstrated by documenting the loss of major retinal antioxidants such as glutathione and taurine and changes in retinal glutamate in these animals 3,47–49 . In the DBA2J mouse model of glaucoma, administration of oral alpha‐luminol decreased oxidative stress and reduced changes in glutamate distribution in their retinas 50 .…”
Section: Discussionmentioning
confidence: 99%