Microwave ablation modeling with AMICA antenna: Validation by means a numerical analysis

Cafarchio, A.; Iasiello, M.; Vanoli, G.P.; Andreozzi, A.

doi:10.1016/j.compbiomed.2023.107669

Cited by 3 publications

(2 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A cooling effect was also predicted in physical models of Deshavar et al [10] and Tucci et al [11]. Additionally, Cafarchio et al [12] predicted an effect of the angle between ablation needle and blood flow direction, which we did not evaluate in our study. However, one would assume different angles when ablating lesions near the portal vein vs. ablating near the hepatic vein due to the liver anatomy.…”

Section: Discussionmentioning

confidence: 47%

“…Therefore, a reliable prediction of the AZV is still difficult [7,8]. Potential influencing factors include the proximity of adjacent large vessels [9], tissue perfusion [10,11] including blood velocity and blood flow direction towards the needle [12], tumour type, and surrounding liver tissue characteristics (healthy parenchyma versus cirrhotic or steatotic conditions) [10,13,14]. Moreover, in vivo studies, notably those by Hines-Peralta et al [15] and Bedoya et al [16], reveal a non-linear relationship between AZV and ablation time.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Factors Impacting Microwave Ablation Zone Sizes: A Retrospective Analysis

Mathy,

Giannakis,

Franke

et al. 2024

Cancers

View full text Add to dashboard Cite

Purpose: Evaluation of the influence of intrinsic and extrinsic conditions on ablation zone volumes (AZV) after microwave ablation (MWA). Methods: Retrospective analysis of 38 MWAs of therapy-naïve liver tumours performed with the NeuWave PR probe. Ablations were performed either in the ‘standard mode’ (65 W, 10 min) or in the ‘surgical mode’ (95 W, 1 min, then 65 W, 10 min). AZV measurements were obtained from contrast-enhanced computed tomography immediately post-ablation. Results: AZVs in the ‘standard mode’ were smaller than predicted by the manufacturer (length 3.6 ± 0.6 cm, 23% below 4.7 cm; width 2.7 ± 0.6, 23% below 3.5 cm). Ablation zone past the tip was limited to 6 mm in 28/32 ablations. Differences in AZV between the ‘surgical mode’ and ‘standard mode’ were not significant (15.6 ± 7.8 mL vs. 13.9 ± 8.8 mL, p = 0.6). AZVs were significantly larger in case of hepatocellular carcinomas (HCCs) (n = 19) compared to metastasis (n = 19; 17.8 ± 9.9 mL vs. 10.1 ± 5.1 mL, p = 0.01) and in non-perivascular tumour location (n = 14) compared to perivascular location (n = 24, 18.7 ± 10.4 mL vs. 11.7 ± 6.1 mL, p = 0.012), with both factors remaining significant in two-way analysis of variance (HCC vs. metastasis: p = 0.02; perivascular vs. non-perivascular tumour location: p = 0.044). Conclusion: Larger AZVs can be expected in cases of HCCs compared with metastases and in non-perivascular locations. Using the ‘surgical mode’ does not increase AZV significantly.

show abstract

Section: Discussionmentioning

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Factors Impacting Microwave Ablation Zone Sizes: A Retrospective Analysis

Mathy,

Giannakis,

Franke

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

Fluid Flow and Thermal Analysis of Blood Flow in an Automatically Generated 2d Vascular Network Featuring the Porous Media-Based Outflow Boundary Conditions

Adabbo,

Andreozzi,

Iasiello

et al. 2025

Comput Thermal Scien

View full text Add to dashboard Cite

Blood flow and thermal analyses in biological tissues are utterly important to better understand the transport phenomena in human tissues with reference to cardiovascular diseases, drug delivery, and thermal ablation. In the existing literature, there is room for new computationally lighter numerical analyses, including both fluid flow and heat transfer. This paper presents an analysis of blood thermo-fluid dynamics within an automatically generated two-dimensional (2D) vascular network, employing the constrained constructive optimization algorithm for structure generation, the porous media assumption for outflow boundary conditions, and heat transfer coefficient analysis for terminal vessels. Through comparisons with theoretical results, the model demonstrates mathematical robustness. Results of the simulations show that blood velocity decreases with increasing number of bifurcations, offering quantitative insights into its decay in magnitude and on its impact on heat transfer. Blood temperature rises in vessels with low velocity, hindering its cooling effects in the surrounding tissues. The study highlights the influence of bifurcation levels on heat transfer coefficient reduction, suggesting longer pathways and time periods to reach high temperature within the blood vessels, due to the cooling effect of pulsating blood flow in larger vessels. The quantitative analysis of the heat transfer coefficient and Nusselt number provides insights into heat transfer between blood and the surrounding tissue, offering also valuable information for numerical bioheat models in thermal therapy simulations.

show abstract