Microwave ablation of primary and secondary liver tumours: ex vivo, in vivo, and clinical characterisation

Abstract

For the selected MW ablation device, ex vivo data on bovine liver was more predictive of the actual clinical performance on liver malignancies than an in vivo porcine model. Equivalent MW treatments yielded a significantly different response for HCC and metastases at higher deposited energy, suggesting that outcomes are not only device-specific but must also be characterised on a tissue-by-tissue basis.

A prognostic nomogram for colorectal cancer liver metastases after percutaneous thermal ablation

“…For patients who cannot undergo surgical resection, thermal ablation can help maximise the necrosis of metastases and induce a progression-free interval without the need for systemic therapy [38,39]. In the present study, those with unresectable CRCLM in the primary cohort had a median OS of 13.9 months.…”

Transcatheter arterial chemoembolization combined with simultaneous DynaCT-guided microwave ablation in the treatment of small hepatocellular carcinoma

“…Laparoscopic ultrasound (LUS; ALOKA ProSound α5, Aloka, Tokyo, Japan) was used during microwave ablation probe (ECO-100AI10, ECO Microwave System Co, Nanjing, China) insertion in order to avoid injury to the large vessels and the bile duct. When the optimal insertion angle and depth was achieved, the specific power and time settings were typically 5-10 min with a 65 watt (W) ablation [15]. The duration of ablation was directly related to the quality of the surrounding liver tissue, lesion depth and demarcation line length.…”

Evaluation of microwave ablation of liver malignancy with enabled constant spatial energy control to achieve a predictable spherical ablation zone

“…Hepatocellular carcinoma and liver metastasis from colorectal cancer are counted among the most common hepatic cancers [1]. Surgical treatment remains the treatment of choice for the curative therapy of liver malignancies; however, a considerable number of patients are inoperable [2,3]; consequently, alternative treatments, such as radiofrequency ablation (RFA) [4], microwave ablation (MWA) [5,6], laserinduced-thermotherapy (LITT) [7], cryoablation [8], transarterial chemoembolization (TACE) and stereotactic radiotherapy, have advanced over the last decade. MWA has been shown to combine the benefits of RFA while having its own benefits, namely, higher ablation volumes, shortened treatment duration, possibility of multiple antenna use, reduced susceptibility to the heat-sink effect and higher rates of local tumour control [9][10][11][12][13][14][15].…”