Microwave assisted cisplatin-loaded CeO2/GO/c-MWCNT hybrid as drug delivery system in cervical cancer therapy

Saranya, J.; Sreeja, B. S.; Kumar, Pradeep

doi:10.1007/s13204-023-02856-9

Cited by 2 publications

(3 citation statements)

References 43 publications

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Section: Resultsmentioning

confidence: 99%

“…However, there was a noticeable change in the cancer cell morphology, showing that the concentration boosted the antitumor action of the CNTs/Gel/Cp and Cp to some extent. At concentrations of 10 and 20 µg/mL, a significant increase in red fluorescence was observed, indicating a marked increase in cancer cell death, and the CNTs/Gel/Cp and Cp groups showed a strong antitumor effect [56]. In the control group, cancer cells were observed to be densely clustered, and there was little difference in the number of cancer cells between the 1 µg/mL concentration group and the control group.…”

Section: In Vitro Antitumor Effectmentioning

confidence: 97%

“…However, there was a noticeable change in the cancer cell morphology, showing that the concentration boosted the antitumor action of the CNTs/Gel/Cp and Cp to some extent. At concentrations of 10 and 20 µg/mL, a significant increase in red fluorescence was observed, indicating a marked increase in cancer cell death, and the CNTs/Gel/Cp and Cp groups showed a strong antitumor effect [56]. In order to visually demonstrate the antitumor effect of CNTs/Gel/Cp, we employed the AO/EB staining experiment to investigate the impact of the nano-drug delivery system on cell apoptosis and survival (Figure 14).…”

Section: In Vitro Antitumor Effectmentioning

confidence: 99%

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Gelatin-Functionalized Carbon Nanotubes Loaded with Cisplatin for Anti-Cancer Therapy

Bao

Wang

et al. 2023

Polymers

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Cisplatin (Cp), a chemotherapeutic agent, interacts with purines on tumor DNA, causing tumor cell apoptosis. However, cisplatin has the characteristics of non-specific distribution and lack of selectivity, resulting in systemic toxicity. Moreover, it cannot maintain the drug’s high concentration in the tumor-weak acid environment. These flaws of cisplatin restrict its use in clinical applications. Therefore, a pH-responsive carbon nanotube-modified nano-drug delivery system (CNTs/Gel/Cp) was constructed in this study using gelatin (Gel)-modified carbon nanotubes (CNTs/Gel) loaded with cisplatin to release drugs precisely and slowly, preventing premature inactivation and maintaining an effective concentration. When MCp:MCNTs/Gel = 1:1, the drug reaches the highest loading rate and entrapment efficiency. To achieve the sustained-release effect, CNTs/Gel/Cp can release the medicine steadily for a long time in a pH environment of 6.0. Additionally, CNTs/Gel/Cp display antitumor properties comparable to cisplatin in a manner that varies with the dosage administered. These findings indicate that CNTs/Gel/Cp have an effective, sustained release of cisplatin and a good antitumor effect, providing a theoretical and experimental basis for the clinical application of modified carbon nanotubes (CNTs) as a new drug delivery system.

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Section: Resultsmentioning

confidence: 99%

Section: In Vitro Antitumor Effectmentioning

confidence: 97%

“…However, there was a noticeable change in the cancer cell morphology, showing that the concentration boosted the antitumor action of the CNTs/Gel/Cp and Cp to some extent. At concentrations of 10 and 20 µg/mL, a significant increase in red fluorescence was observed, indicating a marked increase in cancer cell death, and the CNTs/Gel/Cp and Cp groups showed a strong antitumor effect [56]. In order to visually demonstrate the antitumor effect of CNTs/Gel/Cp, we employed the AO/EB staining experiment to investigate the impact of the nano-drug delivery system on cell apoptosis and survival (Figure 14).…”

Section: In Vitro Antitumor Effectmentioning

confidence: 99%

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