Microwave-Assisted Hydrolysis of Chitosan from Shrimp Shell Waste for Glucosammine Hydrochlorid Production

Zaeni, Ahmad; Safitri, Endang; Fuadah, Badrotul; Sudiana, I Nyoman

doi:10.1088/1742-6596/846/1/012011

Cited by 15 publications

(14 citation statements)

References 14 publications

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“…Microwave merupakan metode pemanasan tinggi dengan gelombang mikro. Metode microwave meningkatkan efisiensi dan efektivitas ekstraksi bahan aktif berbagai jenis rempah-rempah, tanaman herbal, dan buah-buahan (Chan et al, 2015;Mashuni et al, 2020) serta sebagai sumber energi eksternal untuk membantu mempercepat terjadinya suatu reaksi kimia (microwave assisted reactions) (Zaeni et al, 2017;Wang et al, 2018). Keuntungan dari teknologi berbasis microwave yaitu dapat membantu pengurangan proses kebutuhan energi, waktu pemanasan relatif singkat, proses mudah dan tepat, pemanasan yang selektif, mutu produk akhir lebih baik, dan meningkatkan kualitas bahan yang dihasilkan (Ingole, 2015).…”

Section: Alchemy Jurnal Penelitian Kimiaunclassified

“…Di bidang kesehatan bermanfaat sebagai penyembuhan luka, regenerasi jaringan, bahan hemostatik, dan kapsul obat (Yanti et al, 2018). Kitosan dari cangkang kepiting bakau dihidrolisis menggunakan asam menjadi glukosamin hidroklorida (GlcN HCl) (Zaeni et al, 2017), sehingga dimanfaatkan sebagai bahan dasar pembuatan kapsul obat. GlcN HCl dapat larut dalam air karena adanya gugus -OH dan NH3Cl pada unit-unit polimer yang sudah menjadi lebih kecil (Suptijah el al., 2014) Obat kapsul adalah sediaan padat yang terdiri dari obat dalam cangkang keras atau lunak yang dapat larut (Gunsel and Kanig, 1976;Suparman et al, 2018).…”

Section: Alchemy Jurnal Penelitian Kimiaunclassified

“…Isolasi kitin dari cangkang kepiting bakau menggunakan metode hasil modifikasi dalam penelitian Arifin dan Irawan (2015) dan Zaeni et al (2017). Proses deproteinasi dilakukan dengan menimbang cangkang kepiting halus sebanyak 200 g kemudian tambahkan larutan NaOH 3,5% (v/v) dengan perbandingan 1:10 (b/v), dimasukan ke dalam microwave selama 15 menit dengan daya 100 W. Selanjutnya dilakuan proses demineralisasi, sampel hasil deproteinasi yang sebelumnya telah dikeringkan ditambahkan HCl 1 N dengan rasio 1:15 (b/v) diaduk selama 1 jam pada suhu kamar.…”

Section: Isolasi Kitinunclassified

“…Setelah proses demineralisasi, proses penghilangan warna atau dekolorisasi sampel dilakukan dengan menggunakan pelarut aseton 1:5 (b/v) kemudian didiamkan pada suhu ruang. Zaeni et al (2017). Kitin ditimbang 1 g kemudian ditambahkan larutan NaOH 50% perbandingan (1:20 w/v).…”

Section: Isolasi Kitinunclassified

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Pemanfaatan Kitosan dari Cangkang Kepiting Bakau (Scylla serrata) dengan Metode Microwave sebagai Bahan Dasar Kapsul Obat

et al. 2021

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Cangkang kepiting bakau (Scylla serrata) mengandung senyawa kitin yang dapat ditransformasi menjadi kitosan sebagai bahan pembuatan kapsul obat. Proses transfomasi ini masih perlu untuk dikembangkan lanjut. Penelitian ini bertujuan untuk menghasilkan kapsul obat berbahan dasar cangkang kepiting bakau dengan metode microwave. Metode isolasi kitin dari cangkang kepiting bakau meliputi proses deproteinasi, demineralisasi, dan dekolorisasi. Sintesis kitosan menggunakan metode microwave (daya 450 watt selama 15 menit) dalam pelarut NaOH 50% (b/v) dengan perbandingan 1:20 (b/v), selanjutnya kitosan dihidrolisis menggunakan larutan HCl 20% (v/v) untuk menghasilkan glukosamin hidroklorida (GlcN HCl). Pembuatan kapsul obat dengan perbandingan GlcN HCl dan larutan sukrosa yaitu masing-masing 3:1, 3:3, dan 3:5. Rendemen kitosan yang diperoleh sebanyak 37,5% dengan derajat deasetilasi 83,8%. Kapsul obat diperoleh perlakuan terbaik pada perbandingan GlcN HCl-larutan sukrosa 3:1. Berdasarkan analisis terhadap spektra kapsul obat, diidentifikasi adanya gugus O−H, −CH3, N−H, C−N, C−O, dan β-1,4-glikosidik. Karakteristik sifat fisik menunjukkan bahwa kapsul obat memiliki kadar air 12,7%, uji waktu hancur 13 menit 34 detik dan kelarutan dalam asam 3 menit 17 detik. Hasil penelitian menunjukkan bahwa kitosan cangkang kepiting bakau telah memenuhi kriteria bahan dasar kapsul obat sesuai kriteria farmakope Indonesia.Utilization of Chitosan from Mangrove Crab Shell (Scylla serrata) using the Microwave Method as a Base Material for Medicinal Capsules. The mangrove crab shell (Scyllaserrata) contains a chitin compound potentially transformed into chitosan as an ingredient for medicinal capsules. The research on this transformation process needs further developments. This research aims to produce chitin-based medicinal capsules of mangrove crab shells by microwave methods. The chitin isolation method of mangrove crab shells covers the process of deproteinization, demineralization, and decoloration. The synthesis of chitosan used microwave methods (450 watts of power for 15 minutes) in the solvent of 50% NaOH (w/v) with a ratio of 1:20 (b/v). Chitosan was then hydrolyzed using 20% HCl (v/v) solution to produce glucosamine hydrochloride (GlcN HCl). Preparation of drug capsules with a ratio of GlcN HCl and sucrose solution, namely 3:1, 3:3, and 3:5, respectively. The chitosan yield was obtained as much as 37.5% with a deacetylation degree of 83.8%. The best treatment of the medicinal capsules was obtained on the ratio of GlcN HCl and sucrose solution 3:1. The FTIR analysis of medicinal capsules are identified by the presence of the O−H, −CH3, N−H, C−N, C−O, and β-1.4-glycosidic. The physical characterization showed that the medicinal capsules have a water content of 12.7%, the test of destroyed time of 13 minutes 34 seconds, and soluble in acid that is 3 minutes 17 seconds. The results show that chitosan prepared from mangrove crab shell is potentially used as a basic ingredient for medicinal capsules because it met the criteria for Indonesian pharmacopoeial capsules.

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Section: Alchemy Jurnal Penelitian Kimiaunclassified

Section: Isolasi Kitinunclassified

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Pemanfaatan Kitosan dari Cangkang Kepiting Bakau (Scylla serrata) dengan Metode Microwave sebagai Bahan Dasar Kapsul Obat

et al. 2021

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“…Non-thermal microwave action is effective for thermoplastic and thermosetting dielectrics only. Controllable microwave-assisted chitosan processing has to be carried out in water, hydrogen peroxide, or some other polar liquids [16,69,70]. Besides, in setups for non-thermal polymer processing, only a small part of the microwave power is used and special ballast loads are required to absorb the main part of it.…”

Section: Advantages and Power Efficiency Of The Cos Production In Ebpmentioning

confidence: 99%

Chitosan Plasma Chemical Processing in Beam-Plasma Reactors as a Way of Environmentally Friendly Phytostimulants Production

et al. 2021

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A novel technique of phytoactive water-soluble chitooligosaccharide (COS) production in low-temperature plasma is described. Design, operation, and control of plasma chemical reactors used to produce COS from the powder of high molecular weight chitosan are presented. The electron beam plasma is strongly non-equilibrium and chemically active; plasma was excited by injecting the scanning electron beam into reaction volume filled with aerosol, containing oxygen and chitosan powder. Plasma chemical processes, responsible for the raw chitosan destruction and techniques of these processes to obtain control of products of optimal molecular weight, are considered. COS, in amounts sufficient for laboratory tests with some plants, were produced. Tests showed that the addition of COS into the liquid growing medium at 0.25 and 1 mg/mL stimulates root growth in Arabidopsis thaliana seedlings (Col-0) by up to 40%, with respect to control plants. Foliar application of these COS formulations at 0.25 mg/mL on tomato plants (cv. Micro-Tom) also resulted in increases between 11.9% and 36% in two important plant productivity indicators (flower and fruit numbers) compared to the control plants. Being environmentally friendly (and resource saving) the electron beam plasma technology of renewable natural biopolymer processing can be considered as a competitive way to produce biostimulants for commercial agriculture.

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Towards a greener future: Bioactive compounds extraction from shrimp shells using eco‐friendly techniques

Putra,

Rizkiyah,

Che Yunus

et al. 2024

eFood

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This review explores the impact of green extraction techniques on the utilization of shrimp shell waste, focusing on the extraction of bioactive compounds. The purpose of this research is to assess the effectiveness of eco‐friendly extraction methods in maximizing the value of shrimp shell waste while minimizing environmental impact. Through a comprehensive analysis of recent studies, the findings reveal the significant potential of green extraction techniques, such as ultrasound‐assisted extraction and enzyme‐assisted extraction, in efficiently extracting bioactive compounds from shrimp shells. These techniques not only enhance the extraction yield but also contribute to reducing energy consumption and minimizing the use of hazardous chemicals. The review also discusses the challenges and future directions in green extraction, highlighting the need for interdisciplinary collaboration and technological innovation to further optimize extraction processes. Overall, the adoption of green extraction techniques offers promising opportunities for sustainable shrimp shell waste utilization, with potential applications in various industries such as pharmaceuticals, nutraceuticals, and cosmetics.

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Microwave-Assisted Hydrolysis of Chitosan from Shrimp Shell Waste for Glucosammine Hydrochlorid Production

Cited by 15 publications

References 14 publications

Pemanfaatan Kitosan dari Cangkang Kepiting Bakau (Scylla serrata) dengan Metode Microwave sebagai Bahan Dasar Kapsul Obat

Pemanfaatan Kitosan dari Cangkang Kepiting Bakau (Scylla serrata) dengan Metode Microwave sebagai Bahan Dasar Kapsul Obat

Chitosan Plasma Chemical Processing in Beam-Plasma Reactors as a Way of Environmentally Friendly Phytostimulants Production

Towards a greener future: Bioactive compounds extraction from shrimp shells using eco‐friendly techniques

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