Microwave Assisted Medicinal Chemistry

Abstract

Microwave irradiation has been used to enhance organic reactions since the mid 80's, its use within the field of medicinal chemistry is not so widely evident in the literature. The present review highlights the use of microwave chemistry as an important tool for the fast development of structure activity relationship in several programs related to various therapeutic areas.

Microwave‐Assisted Continuous Flow Organic Synthesis (MACOS)

“…Considering the fast reaction onset provided by microwaves of only a few seconds, and the ratio between the volume of the NMR chip and the microwave cell, which allows the latter to be divided into different zones for analysis, several data An important discipline where microwave irradiation has already had a major impact is medicinal chemistry [25][26][27][28][29][30]. Microwave-assisted continuous flow organic synthesis (MACOS) has also been used in this field.…”

Anionic hydrogen‐transfer polymerization of N‐isopropylacrylamide under microwave irradiation

“…The microwave irradiation method has been exploited for many chemical reactions. A number of review papers on microwave‐assisted chemical reactions have been published . This method allows rapid and direct heating of the reaction media.…”

“…A number of review papers on microwave-assisted chemical reactions have been published. [16][17][18][19] This method allows rapid and direct heating of the reaction media. In most cases, microwave can dramatically reduce reaction times and increase product yields.…”

Solvent-free microwave-promoted Michael addition of aza-nucleophiles to benzo[b]thiophen-2-yl-2-propenone

“…It was found that microwave irradiation and solid support in solventless conditions considerably shortens reaction time and greatly reduces waste production. [16][17][18] In this paper we report the synthesis in good yield of a variety of β-aminoketones of potential biological interest under environmentally friendly conditions, using microwave-supported Michael-addition. This protocol includes reactions that can be conducted without solvent and in absence of metal catalysts, a highly desirable experimental condition.…”