Microwave-assisted radical polymerization of dialkyl fumarates

Cortizo, M. Susana; Laurella, Sergio Luis; Alessandrini, José Luis

doi:10.1016/j.radphyschem.2006.11.003

Cited by 30 publications

(21 citation statements)

References 21 publications

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“…One of them, the monomer polymerizes and then degrades during the course of reaction, attaining an equilibrium average molecular weight. Similar behavior has been found in methyl methacrylate and some dialkyl fumarate polymerized under microwave conditions (Madras and Karmore, 2001;Cortizo et al, 2007). The other possibility, considering the slow increase of the temperature at early period, is the formation of long chains up to 1 min of reaction and short chains when the temperature overcome 60 1C, which is the optimum decomposition temperature for BP.…”

Section: Article In Presssupporting

confidence: 71%

Structure and properties of poly(benzyl acrylate) synthesized under microwave energy

Oberti

Schiavoni

Cortizo

2008

Radiation Physics and Chemistry

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Section: Article In Presssupporting

confidence: 71%

Structure and properties of poly(benzyl acrylate) synthesized under microwave energy

Oberti

Schiavoni

Cortizo

2008

Radiation Physics and Chemistry

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“…Poly(diisopropylfumarate) (PDIPF) and poly(dicyclohexylfumarte) (PDCF) were synthesized by microwaveassisted radical polymerization, using benzoyl peroxide as the initiator (Cortizo et al, 2007). Briefly, 1 g monomer was added to a previously weighed amount of initiator (60 mM) under nitrogen gas into a 25 cm 3 conical Pyrex flask closed by a septum.…”

Section: Synthesis and Characterization Of Polymersmentioning

confidence: 99%

“…However, polyfumarates would be expected to exhibit better mechanical properties than polyesters. Our group has previously described a rapid and efficient method to synthesize polydialkyl fumarates of high molecular weight, based on a new methodology that uses microwave energy (Cortizo et al, 2007). We were interested in selecting new materials (polyesters and polyfumarates) and to compare their ability to act as a scaffold for bone tissue.…”

mentioning

confidence: 99%

Biocompatibility and biodegradation of polyester and polyfumarate based-scaffolds for bone tissue engineering

Cortizo

Molinuevo

Cortizo

2008

J Tissue Eng Regen Med

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Biodegradable and biocompatible polymeric scaffolds have been recently introduced for tissue regeneration purpose. In the present study we aimed to develop polymeric-based scaffolds for bone regeneration. Two polyesters, poly-β-propiolactone (PBPL), poly-ε-caprolactone (PCPL) and two polyfumarates, polydiisopropyl fumarate (PDIPF), polydicyclohexyl fumarate (PDCF) were chosen to prepare films which can support osteoblastic growth. Scanning electron microscopy and water contact angle were used to characterize the matrices. Biodegradation studies were performed both in PBS buffer and using an in vitro macrophage degradation assay. Mouse calvaria-derived MC3T3E1 cells and UMR106 rat osteosarcoma cell lines were used to perform biocompatibility and cytotoxicity studies. The polyesters, the most hydrophilic polymers studied, showed a rougher and more porous surfaces than the polyfumarates. Under acellular conditions, only PBPL was degraded by hydrolytic mechanisms. However, macrophages performed an active degradation of all polymeric films. Osteoblasts developed well-defined actin fibres without evidence of cytotoxicity when growing on the films. The number of UMR106 osteoblasts that adhered to the PBPL-based film was higher than that of the cells attached to the PECL and polyfumarates (PDIPF and PDCF) matrices. Both UMR106 and MC3T3E1 osteoblastic lines showed protein levels comparable to control conditions, demonstrating that they grew well on all surfaces. However, UMR106 cells showed a significant increase in proliferation on polyester-derived scaffolds (PBPL and PECL). The alkaline phosphatase activity of UMR106, an osteoblastic marker, was significantly higher than that of control plastic dishes. MC3T3E1 cells expressed similar levels of this differentiation marker in all polymeric matrices. We found similar collagen protein content after 48 h culture of UMR106 cells on all surfaces. However, important differences were evident in the MC3T3E1 line. In conclusion, the synthetic polymeric-based scaffold we have developed and studied supports adhesion, growth and differentiation of two osteoblastic cell lines, suggesting that they could be useful in bone tissue regeneration.

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“…In a further work, Alessandrini and coworkers showed polymerization of different dialkyl fumarates using a domestic MW oven in the presence of benzoyl peroxide as the initiator. [39] In comparison with experimental data from the literature an acceleration of reaction rate was found for all studied monomers. Lu and coworkers investigated the influence of carriers (Al 2 O 3 , SiO 2 , and MgO) on the MW-assisted (domestic MW oven) polymerization of acrylamide and 2-ethylhexyl acrylate.…”

Section: Free Radical Homopolymerizationmentioning

confidence: 62%

Recent Advances in Microwave-Assisted Polymer Synthesis

2007

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In the past few years the use of microwave irradiation in polymer science has become a well-established technique to drive and promote chemical reactions. The main advantages of microwave heating are a strong reduction in reaction time and a high potential to contribute to green and sustainable chemistry. This article provides a short review of recent examples in the field of microwave-assisted polymer synthesis with special emphasis on radical polymerizations, step-growth polymerizations, ring-opening polymerizations, and polymer modifications.

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Microwave-assisted radical polymerization of dialkyl fumarates

Cited by 30 publications

References 21 publications

Structure and properties of poly(benzyl acrylate) synthesized under microwave energy

Structure and properties of poly(benzyl acrylate) synthesized under microwave energy

Biocompatibility and biodegradation of polyester and polyfumarate based-scaffolds for bone tissue engineering

Recent Advances in Microwave-Assisted Polymer Synthesis

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