Microwave-assisted rapid synthesis of sugar-based pyrazole derivatives with anticancer activity in water

Abstract

A rapid, efficient and green method has been developed for the synthesis of some novel sugar-based pyrazole derivatives in eco-friendly water under microwave irradiation in good yields.

Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry

“…al. 71 incorportated the above-mentioned protocol into the synthesis of some novel sugar-based pyrazole derivatives 87 through the MW-assisted cyclization of sugar-based phenyl (21) This journal is © The (24)). 72 This class of joined aromatic/heteroaromatic pyrazole units represents an important scaffold in drug design resembling nucleic acid base pairs (cytosine and thymine), whose geometries and electronic distributions provide the basis of action for many known therapeutics.…”

Greener and Environmentally Benign Methodology for the Synthesis of Pyrazole Derivatives

“…They carried out reaction at various temperature and use different catalyst but in presence of iodine at 60 ο C within 20 min phenyl hydrazine, malononitrile and a diverse range of aldehydes reacted & product obtain in high yield 85-94% (Scheme 9). Reaction goes by knoevenagel condensation between aldehyde derivatives and malononitrile gives 1,2 unsaturated compound which attacked by phenyl hydrazine (Michael addition) after which intramolecular cyclisation gives pyrazole (9).…”

“…Out of two “nitrogen” atom one is basic and other is neutral. Pyrazole have more attention of researcher due to their wide range of biological activities, such as antimicrobial, [4] antiviral, [5] antitumor, [6] anti‐inflammatory, [7] antioxidant, [8] anticancer, [9] analgesic, [10] anti HIV, [11] anticonvulsant, [12] anti‐angiogenic, [13] (Figure 1, a–j) and antidiabetic [14] . Pyrazole is main core of many important drugs such as Celebrex, rimonabant, betazole, mepirizole, lonazolac, viagra [15] .…”

Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities

“…Additionally, benzimidazoles treat mitochondrial dysfunction in Alzheimer’s disease [ 22 ], possess neurotropic, psychoactive, analgesic effects [ 23 ], anticoagulant proprieties [ 24 ] and are efficient agents in Diabetes mellitus [ 25 ]. Additionally, pyrazole compounds possess a diversity of biological activities as analgesic [ 26 , 27 , 28 ], anticonvulsivant [ 29 , 30 ], antitumor [ 31 , 32 , 33 , 34 ], antidiabetic [ 35 , 36 ], antimicrobial [ 37 , 38 , 39 , 40 , 41 , 42 , 43 ], antipyretic [ 44 , 45 ], antiviral [ 46 , 47 ], antimalarial [ 48 , 49 ], local anesthetic [ 50 ] and so forth.…”