Microwave-Assisted Syntheses in Organic Chemistry

Kiss, Nóra Zsuzsa; Bálint, Erika; Keglevich, György

doi:10.1007/978-3-319-30632-2_2

Cited by 16 publications

(9 citation statements)

References 109 publications

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“…The application of the MW technique may be advantageous in several organic reactions and organophosphorus transformations as well [23]. The reactions may proceed faster and the use of a catalyst and/or a solvent is often evitable [24].…”

Section: Scheme 1 Synthetic Routes Of Isoindolin-1-one Phosphonates mentioning

confidence: 99%

Study on the Microwave-Assisted Batch and Continuous Flow Synthesis of N-Alkyl-Isoindolin-1-One-3-Phosphonates by a Special Kabachnik–Fields Condensation

et al. 2020

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A simple and efficient microwave (MW)-assisted method was elaborated for the catalyst-free synthesis of isoindolin-1-one-3-phosphonates by the three-component condensation of 2-formylbenzoic acid, aliphatic primary amines and various dialkyl phosphites. The batch and the continuous flow reactions were optimized in respect of the temperature, the reaction time and the molar ratio of the starting materials. To evaluate the potential of MW irradiation, comparative thermal experiments were also carried out. In order to obtain “real time” information about the condensation, the special Kabachnik–Fields reaction of 2-formylbenzoic acid, butylamine and diethyl phosphite was monitored by in situ FT-IR spectroscopy. The novel title compounds could be prepared in high yields at low temperature under a short reaction time. A suitable method could also be developed for the preparation of the isoindolin-1-one-3-phosphonates at a “few g” scale by using a continuous flow MW reactor.

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Section: Scheme 1 Synthetic Routes Of Isoindolin-1-one Phosphonates mentioning

confidence: 99%

Study on the Microwave-Assisted Batch and Continuous Flow Synthesis of N-Alkyl-Isoindolin-1-One-3-Phosphonates by a Special Kabachnik–Fields Condensation

et al. 2020

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“…In practical organic chemistry, the use of the MW technique has become common in the last few decades [8]. In most cases, MW-assisted reactions proceed faster, the selectivity is higher and the catalyst-and the solvent are avoidable [9].…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Multicomponent Syntheses of Heterocyclic Phosphonates

Bálint

Popovics-Tóth

Tajti

et al. 2020

The 24th International Electronic Conference on Synthetic Organic Chemistry

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Organophosphorus compounds play an important role in the medicinal-or agricultural industry, and in the human body as well. Over the last years, heterocyclic phosphonates have received an intensively growing interest due to their potential biological activity. An efficient tool for the preparation of such derivatives is their synthesis via multicomponent reactions. These transformations possess several criteria of an "ideal synthesis", such as the high atom economy, the fast and simple accomplishment, the energy efficiency and the environmentally friendliness. A number of heterocyclic phosphonates were prepared by us utilizing multicomponent syntheses. In this proceeding, the synthesis of the diethyl (2-amino-3-cyano-4H-chromen-4-yl)phosphonate by the condensation of salicylaldehyde, malononitrile and diethyl phosphite is briefly introduced. The reaction was optimized in respect of the catalyst type, the catalyst amount, the reaction time, and the temperature.

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“…Unlike conductive heating, the thermal mechanisms of rate acceleration are the superheating effect of solvents; the formation of so-called molecular radiators; the selective heating by using a strongly absorbing microwave catalyst or reagent in a less polar reaction medium; and the elimination of wall effects found in convective heating. A large number of green and sustainable approaches towards microwave-assisted organic synthesis (MAOS) have been reported, showing different advantages when compared with conventional heating protocols [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. Microwave technology could also allow reactions at temperatures up to 300 °C and pressures up to 80 bar with safety priority and excellent parameter controls.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Microwave-Assisted Production of Hydroxymethylfurfural by Hydrolysis of Cellulose Derivatives—A Review

Delbecq

Len

2018

Molecules

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The concepts of sustainable development, bioeconomy, and circular economy are being increasingly applied for the synthesis of molecules of industrial interest. Among these molecules, hydroxymethylfurfural as a platform molecule is the subject of various research approaches to improve its synthesis and productivity, and extend its potential uses. Accordingly, this review paper aims essentially at outlining recent breakthroughs obtained in the field of hydroxymethylfurfural production from sugars and polysaccharide feedstocks under microwave-assisted technology. The review discusses advances obtained via microwave activation in major production pathways recently explored, split into the following categories: (i) use of various homogeneous catalysts like mineral or organic acids, metal salts, or ionic liquids; (ii) feedstock dehydration making use of various solid acid catalysts; and (iii) non-catalytic routes.

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Microwave-Assisted Syntheses in Organic Chemistry

Cited by 16 publications

References 109 publications

Study on the Microwave-Assisted Batch and Continuous Flow Synthesis of N-Alkyl-Isoindolin-1-One-3-Phosphonates by a Special Kabachnik–Fields Condensation

Study on the Microwave-Assisted Batch and Continuous Flow Synthesis of N-Alkyl-Isoindolin-1-One-3-Phosphonates by a Special Kabachnik–Fields Condensation

Microwave-Assisted Multicomponent Syntheses of Heterocyclic Phosphonates

Recent Advances in the Microwave-Assisted Production of Hydroxymethylfurfural by Hydrolysis of Cellulose Derivatives—A Review

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