Microwave-assisted synthesis and antibacterial activity of 1-(5-((2-(4-bromobenzoyl)-3-methylbenzofuran-5-yl)methyl)-2-((1-aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethanones

Reddy, E. Rajasheker; Ramesh, S.; Anitha, Kadimi; Reddy, A. R.; Reddy, V. Prabhakar

doi:10.1016/j.cdc.2021.100730

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…After completion of the reaction, petroleum ether was added to the reaction mixture with continuous stirring to obtain the final products in the form of precipitates. The precipitates were filtered, washed with distilled waterand purified by recrystallization.The advantages of these preparatory protocols are simplicity, very short reaction times, generality and the elaboration of substituted benzofuran–oxadiazole and benzofuran–triazole with high to excellent yields compared toconventional synthetic approaches and microwave methods already cited for generally synthetic approaches for oxadiazole and triazole derivatives, and specifically benzofuran–oxadiazole and benzofuran–triazole scaffolds [ 29 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

Exploring the Synergistic Anticancer Potential of Benzofuran–Oxadiazoles and Triazoles: Improved Ultrasound- and Microwave-Assisted Synthesis, Molecular Docking, Hemolytic, Thrombolytic and Anticancer Evaluation of Furan-Based Molecules

et al. 2022

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Ultrasound- and microwave-assisted green synthetic strategies were applied to furnish benzofuran–oxadiazole 5a–g and benzofuran–triazole 7a–h derivatives in good to excellent yields (60–96%), in comparison with conventional methods (36–80% yield). These synthesized derivatives were screened for hemolysis, thrombolysis and anticancer therapeutic potential against an A549 lung cancer cell line using an MTT assay. Derivatives 7b (0.1%) and 5e (0.5%) showed the least toxicity against RBCs. Hybrid 7f showed excellent thrombolysis activity (61.4%) when compared against reference ABTS. The highest anticancer activity was displayed by the 5d structural hybridwith cell viability 27.49 ± 1.90 and IC50 6.3 ± 0.7 μM values, which were considerably lower than the reference drug crizotinib (IC50 8.54 ± 0.84 μM). Conformational analysis revealed the spatial arrangement of compound 5d, which demonstrated its significant potency in comparison with crizotinib; therefore, scaffold 5d would be a promising anticancer agent on the basis of cytotoxicity studies, as well as in silico modeling studies.

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Section: Methodsmentioning

confidence: 99%

Exploring the Synergistic Anticancer Potential of Benzofuran–Oxadiazoles and Triazoles: Improved Ultrasound- and Microwave-Assisted Synthesis, Molecular Docking, Hemolytic, Thrombolytic and Anticancer Evaluation of Furan-Based Molecules

et al. 2022

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Microwave accelerated green approach for tailored 1,2,3–triazoles via CuAAC

George

Singh

et al. 2022

Sustainable Chemistry and Pharmacy

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Microwave-promoted Synthesis of Novel Bioactive N-based Heterocycles

Dinodia

2023

MROC

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Our environment is in a continuous state of change which in turn demands for sustainable, eco-friendly, and safer chemistry techniques. This in turn has lead to the green chemistry principles coming into the picture in recent years. Over the years, microwave heating has evolved as a green protocol in organic synthesis. The advantages of the safe and environment-friendly MW heating approach includes a simple experimental setup, products of high purity with high yields, solvent-free reactions, short reaction times, elimination of the side products, and decrease in the rate of by-product formation. Heterocycles, especially nitrogen heterocylces, are important not only because they are present in natural products, but they have widespread applications in pharmaceutical industries as well. These N-Heterocycles are part of many biologically active molecules. In the present review, focus is laid on the developments in MW mediated synthesis of biologically important N-heterocycles in the last 2 years (2020-21).

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Microwave-assisted synthesis and antibacterial activity of 1-(5-((2-(4-bromobenzoyl)-3-methylbenzofuran-5-yl)methyl)-2-((1-aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethanones

Cited by 3 publications

References 11 publications

Exploring the Synergistic Anticancer Potential of Benzofuran–Oxadiazoles and Triazoles: Improved Ultrasound- and Microwave-Assisted Synthesis, Molecular Docking, Hemolytic, Thrombolytic and Anticancer Evaluation of Furan-Based Molecules

Exploring the Synergistic Anticancer Potential of Benzofuran–Oxadiazoles and Triazoles: Improved Ultrasound- and Microwave-Assisted Synthesis, Molecular Docking, Hemolytic, Thrombolytic and Anticancer Evaluation of Furan-Based Molecules

Microwave accelerated green approach for tailored 1,2,3–triazoles via CuAAC

Microwave-promoted Synthesis of Novel Bioactive N-based Heterocycles

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