Microwave-Assisted Synthesis and Characterization of Poly(L-lysine)-Based Polymer/Carbon Quantum Dot Nanomaterials for Biomedical Purposes

Janus, Łukasz; Piątkowski, Marek; Radwan-Pragłowska, And Julia

doi:10.3390/ma12233825

Cited by 13 publications

(31 citation statements)

References 28 publications

(105 reference statements)

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“…The presence of hydrophilic groups, such as hydroxyl, carboxyl, and amino groups, is responsible for the excellent water solubility of the prepared CQDs. The results correspond to other researcher's data [6,8,43,44].…”

Section: Scheme 1 Carbon Quantum Dots With the Free Carboxylic Groupsupporting

confidence: 89%

“…It can be noticed that different carbonizing agents applied for the glucose carbonization ( Table 2) caused diversification in their size and shape. However, their round-shaped morphology is typical for CQDs obtained by the bottom-up approach and corresponds to other researchers' results [36][37][38][39]44]. It can be observed that the Dot-3 sample prepared using tartaric acid is the most uniform one and the average carbon dot diameter is 10 nm.…”

Section: Scheme 1 Carbon Quantum Dots With the Free Carboxylic Groupsupporting

confidence: 87%

“…Conjugated unsaturated bonds are responsible for the luminescence properties, thus, their presence is desirable. Generally, all of the FTIR spectra are typical for quantum dots [43,44]. The spectrum of Dot-1-R shows carbon quantum dots modified with Rhod-OH.…”

Section: Scheme 1 Carbon Quantum Dots With the Free Carboxylic Groupmentioning

confidence: 99%

“…Figure 7 shows PL spectra of the obtained samples and their luminescence dependence on the pH values. Fluorescence spectra of the raw carbon dots (a: Dot-1; d: Dot-2; g: Dot-3; j: Dot-4) are typical for these quantum nanomaterials [2,4,6,8,37,38,43,44]. There is an obvious emission dependence on the visible excitation wavelength, which is typical for quantum nanobojects below 10 nm in size due to the surface defects, conjugated π-domains, as well as crystalline structure disturbance [1][2][3].…”

Section: Spectroscopic Properties Studymentioning

confidence: 99%

“…Thus, it can be concluded that the nanomaterials may be applied in various applications and media of various hydrophility, which is important in the field of diagnostics, and from this point of view is a desirable feature [17][18][19][20][21][22][23]. Our previous research showed that the bottom-up CQD synthesis routes with in situ doping enables the preparation of nanodots with the maximal QY up to 13%, which may be insufficient in some applications [44]. Thus, a novel CQD modification method was developed which resulted in the preparation of the carbon materials with enhanced quantum yield ( Table 2).…”

Section: Spectroscopic Properties Studymentioning

confidence: 99%

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Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

et al. 2020

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Carbon quantum dots (CQDs) are nanoobjects of a size below 10 nm. Due to their favorable features, such as tunable luminescence, unique optical properties, water solubility, and lack of cytotoxicity, they are willingly applied in biomedicine. They can be obtained via bottom-up and top-down methods. However, to increase their quantum yield they must undergo post-processing. The aim of the following research was to obtain a new type of CQDs modified with a rhodamine b derivative to enhance their fluorescence performance without biocompability deterioration. For their preparation glucose was used as a precursor and four different carbonizing agents which affected semi-and final products luminescence properties. The ready nanomaterials were investigated over their chemical structure by FTIR and NMR, whereas morphology was investigated by the TEM method. Their optical properties were determined by UV-VIS spectroscopy. Fluorescence behavior, photo-and pH-stability, as well as solvatochromism showed their applicability in various biomedical applications due to the controlled properties. The samples exhibited excellent antioxidant activity and lack of cytotoxicity on L929 mouse fibroblasts. The results showed that proposed strategy enables preparation of the superior nanomaterials with outstanding luminescence properties such as quantum yield up to 17% which can be successfully applied in cell labelling, bioimaging, and theranostics.Molecules 2020, 25, 736 2 of 18 can release cadmium ions leading to cell death. Importantly, it occurred that quantum dots may undergo certain modifications resulting in the change of their surface or chemical structure [27,28]. Finally, their preparation is expensive. Therefore, there was a need for a novel type of quantum dots which would be suitable for biomedical applications. In 2004, a new type of carbon-based materials was accidentally obtained during nanotube purification [29]. Until then, numerous types of carbon quantum dots (CQDs) have been obtained with various possible applications due to their very attractive properties, such as luminesce, good water solubility, high photostability, resistance to photobleaching or photoblinking, possibility, chemical inertness and, finally, lack of toxicity and biocompability [1][2][3]. Furthermore, CQDs' region of photoluminescence is very broad, starting in the ultraviolet and ending in the near-infrared. Although, until now, the luminescence behavior of carbon nanodots is still not fully clear, it is believed that crucial role plays two factors, namely, that the quantum size is below 10 nm and surface defects which may act as excitation energy traps. Interestingly, CQDs can successfully act as both electron donors and acceptors [2][3][4].CQDs can be prepared from various resources, such as peels (mango, orange, banana, pineapple, onion, seaweed etc.), meat, grains, nuts, or vegetable by-products, which makes them a low-cost material [30,31]. Currently, these nanomaterials are widely applied in drug delivery, gene delivery, biosensing, bioimag...

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Section: Scheme 1 Carbon Quantum Dots With the Free Carboxylic Groupsupporting

confidence: 89%

Section: Scheme 1 Carbon Quantum Dots With the Free Carboxylic Groupsupporting

confidence: 87%

Section: Scheme 1 Carbon Quantum Dots With the Free Carboxylic Groupmentioning

confidence: 99%

Section: Spectroscopic Properties Studymentioning

confidence: 99%

Section: Spectroscopic Properties Studymentioning

confidence: 99%

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Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

et al. 2020

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Progress on Carbon Dots with Intrinsic Bioactivities for Multimodal Theranostics

Zhang,

Liu,

Liu

et al. 2024

Adv Healthcare Materials

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Carbon dots (CDs) with intrinsic bioactivities are candidates for bioimaging and disease therapy due to their diverse bioactivities, high biocompatibility, and multiple functionalities in multimodal theranostics. It is a multidisciplinary research hotspot that includes biology, physics, materials science, and chemistry. This progress report discusses the CDs with intrinsic bioactivities and their applications in multimodal theranostics. The relationship between the synthesis and structure of CDs is summarized and analyzed from a material and chemical perspective. The bioactivities of CDs including anti‐tumor, antibacterial, anti‐inflammatory etc. are discussed from biological points of view. Subsequently, the optical and electronic properties of CDs that can be applied in the biomedical field are summarized from a physical perspective. Based on the functional review of CDs, their applications in the biomedical field are reviewed, including optical diagnosis and treatment, biological activity, etc. Unlike previous reviews, this review combines multiple disciplines to gain a more comprehensive understanding of the mechanisms, functions, and applications of CDs with intrinsic bioactivities.

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Carbon Quantum Dots as Multi‐Purpose Nanomaterial in Stem Cell Therapy

Juybari

Faramarz

Sadeghi³

et al. 2023

Chemistry & Biodiversity

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Some issues, such as their obscure fate or low survival rate into the body during stem cell therapy, should be addressed to boost efficiency. Nanotechnology offers a suitable solution to combat such limitations. Carbon quantum dots (CQDs) are carbon-based nanomaterials and may be used as multi-purpose compounds in stem cell therapy. CQDs are excellent choices for stem cell labeling thanks to their special features such as optical properties and good biocompatibility. Besides, they can modulate the biological function of stem cells, such as their proliferation, homing ability, and differentiation properties. Considering the charismatic feature of CQDs and their broad unique effect on stem cells, the current review aims to summarize the advancements in this field. Hence, we first focused on CQDs synthesis and their applications. In the next section, the stem cell categories will be discussed, and the final part is dedicated to the recent research evaluating the impact of CQDs on stem cell therapy.

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Microwave-Assisted Synthesis and Characterization of Poly(L-lysine)-Based Polymer/Carbon Quantum Dot Nanomaterials for Biomedical Purposes

Cited by 13 publications

References 28 publications

Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

Progress on Carbon Dots with Intrinsic Bioactivities for Multimodal Theranostics

Carbon Quantum Dots as Multi‐Purpose Nanomaterial in Stem Cell Therapy

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