Microwave assisted synthesis of five membered nitrogen heterocycles

Meera, Gopinadh; Rohit, K.; Saranya, Salim; Anilkumar, Gopinathan

doi:10.1039/d0ra05150k

Cited by 51 publications

(21 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The microwave-assisted derivatization (MAD) seems to be an alternative to the conventional heating of the samples during the derivatization process due to several advantages: a shortening of the reaction time, reduction in energy consumption, simplicity, efficiency, elimination of side reactions, higher yield under milder reaction conditions, higher purity of the products formed, and suppression in the rate of by-product formation [ 24 ]. In this paper, we proposed a microwave-assisted amino acid derivatization with FNBT without the application of other organic reagents.…”

Section: Resultsmentioning

confidence: 99%

Simple and Effective Derivatization of Amino Acids with 1-Fluoro-2-nitro-4-(trifluoromethyl)benzene in a Microwave Reactor for Determination of Free Amino Acids in Kombucha Beverages

Jastrzębska

Gralak²,

Brzuzy³

et al. 2022

Materials

View full text Add to dashboard Cite

Kombucha is a fermentation product of sweetened tea with a symbiotic culture of acetic acid and yeast bacteria, consumed worldwide for its health-promoting properties. Few reports can be found about free amino acids among the health-promoting compounds found and determined in kombucha. These compounds influence the sensory properties of kombucha, and they are precursors of bioactive compounds, which have a significant role as neurotransmitters and are involved in biological functions. The presented studies proposed a convenient, simple, and “more green” procedure of the synthesis of amino acid derivatives, assisted by microwave energy, followed by chromatographic determination. The structure of 1-Fluoro-2-nitro-4-(trifluoromethyl)benzene was used as a suitable reagent for the derivatization of free amino acids in fermented kombucha beverages prepared from selected dry fruit such as Crataegus L., Morus alba L., Sorbus aucuparia L., Berberis vulgaris L., Rosa canina L., and black tea. The obtained results were discussed regarding the tested beverages’ application as a source of amino acids in one’s daily diet. The obtained results point out that the proposed microwave-assisted derivatization procedure prior to HPLC analyses allows for a significant time reduction and the limitation of using organic reagents.

show abstract

Section: Resultsmentioning

confidence: 99%

Simple and Effective Derivatization of Amino Acids with 1-Fluoro-2-nitro-4-(trifluoromethyl)benzene in a Microwave Reactor for Determination of Free Amino Acids in Kombucha Beverages

Jastrzębska

Gralak²,

Brzuzy³

et al. 2022

Materials

View full text Add to dashboard Cite

show abstract

“…En general, los reportes para la síntesis de 2-pirazolinas usando reactores de microondas han presentado incremento en los rendimientos y la reducción sustancial de los tiempos de reacción. Los efectos de los solventes son de especial importancia principalmente si se trata de solventes polares apróticos (por ejemplo, DMF) o próticos (por ejemplo, metanol), ya que la absorción principal del microondas es hacia las moléculas polares del solvente y, en este caso, la transferencia de energía es del solvente a las mezclas de reacción y reactivos (Jasril et al, 2019;Khan et al, 2019;Mermer, 2020;Meera et al, 2020;Pradeep, Vishnuvardhan y Thalari, 2021). Las hidrazonas se forman como productos intermedios, que posteriormente se ciclan a 2-pirazolinas en presencia de un reactivo de ciclación adecuado como el ácido acético o asistiendo el proceso por calentamiento no-convencional (figura 8).…”

Section: Energías De Reacciónunclassified

Recientes investigaciones en la síntesis sustentable de pirazolinas

2022

View full text Add to dashboard Cite

En química medicinal, se dirigen continuamente extensos esfuerzos en investigación al descubrimiento de nuevos heterociclos con efectos farmacológicos apropiados. Específicamente, el papel de los derivados del pirazol en la química médica es vital debido a su amplia gama de actividades biológicas. Por esta notable observación, se desarrolla esta revisión con enfoque sobre los avances de procedimientos sintéticos eco-amigables en términos de rendimiento, tiempo de reacción corto y condiciones limpias en la obtención de 2-pirazolinas, a partir de un análisis bibliográfico de investigación que toma como referencia los años 2019 a 2021 con respecto a la obtención de estos sistemas en condiciones simplificadas y energéticamente sustentables.

show abstract

“…In addition reviews dedicating Rh(III)‐catalyzed C‐H bond activation for the construction of heterocycles with sp 3 ‐carbon centers by wang group, [6c] and synthesis of fused five membered N‐ heterocycles by Kaur group have gained a significant attention [6d] . Other reports discussed in this area includes synthesis of bi‐ or tri‐cyclic N ‐Heterocycle by [3+3] cycloaddition of azomethine imine by Das and co‐workers, [6e] Microwave assisted synthesis of five membered nitrogen heterocycles by Meera and co‐workers, [6f] and synthesis of indoles from alkynes and nitrogen sources by Neto and co‐workers [6g] . Likewise, we have also included some of the novel work corresponding to our topic of research reported in the review by Wang group [6h] .…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Synthesis of 5‐MemberedN‐Heterocycles via Rhodium Catalysed Cascade Reactions

et al. 2022

View full text Add to dashboard Cite

Five membered N-heterocycles are significant targets in organic synthesis because of their ubiquitous existence in bioactive natural products and pharmaceuticals. Over the past decade a compelling attractiveness has grown to develop rhodium complex catalysed efficient and atom-economic chemistry to access structurally diverse N-heterocyclic frameworks. This present review enlightens notable progresses and advances in synthesis of 5-membered N-heterocycles via rhodium catalysed cascade reactions (annulations, CÀ H/CÀ C activation, cycloaddition, rearrangement, cyclization, metathesis) from 2018-2021.[a] D.

show abstract

Microwave assisted synthesis of five membered nitrogen heterocycles

Abstract: Microwave assisted synthesis of N-heterocycles with short reaction time, high yields and high product purities along with a decrease in the rate of by-product formation.

Cited by 51 publications

References 30 publications

Simple and Effective Derivatization of Amino Acids with 1-Fluoro-2-nitro-4-(trifluoromethyl)benzene in a Microwave Reactor for Determination of Free Amino Acids in Kombucha Beverages

Simple and Effective Derivatization of Amino Acids with 1-Fluoro-2-nitro-4-(trifluoromethyl)benzene in a Microwave Reactor for Determination of Free Amino Acids in Kombucha Beverages

Recientes investigaciones en la síntesis sustentable de pirazolinas

Recent Advances in the Synthesis of 5‐MemberedN‐Heterocycles via Rhodium Catalysed Cascade Reactions

Contact Info

Product

Resources

About