Microwave-assisted Synthesis of Hybrid Heterocycles as Potential Anticancer Agents

Srinivas, A.; Sunitha, M.; Raju, K. Naga; Ravinder, B.; Anusha, Siluveru; Rajasri, Thallapalli; Swapna, P.; Sushmitha, Dupa; Swaroopa, Deva; Nikitha, G.; Rao, Chakunta Govind

doi:10.17344/acsi.2016.3153

Cited by 11 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During their research in the triazole series, Srinivas et al [33] synthesized different 1,2,3-triazole derivatives type 42a-g and 43a-g, bearing a thiazolidinone moiety. The synthesis was achieved by the condensation reaction between 1,2,3-triazoles 41 with a primary aromatic amine and a thioglycolic acid and/orthiomalic acid.…”

Section: Five Membered Ring Azaheterocycles With More Than Two Heteromentioning

confidence: 99%

Microwave Assisted Reactions of Azaheterocycles Formedicinal Chemistry Applications

et al. 2020

View full text Add to dashboard Cite

Microwave (MW) assisted reactions have became a powerful tool in azaheterocycles chemistry during the last decades. Five and six membered ring azaheterocycles are privileged scaffolds in modern medicinal chemistry possessing a large variety of biological activity. This review is focused on the recent relevant advances in the MW assisted reactions applied to azaheterocyclic derivatives and their medicinal chemistry applications from the last five years. The review is divided according to the main series of azaheterocycles, more precisely 5- and 6-membered ring azaheterocycles (with one, two, and more heteroatoms) and their fused analogues. In each case, the reaction pathways, the advantages of using MW, and considerations concerning biological activity of the obtained products were briefly presented.

show abstract

Section: Five Membered Ring Azaheterocycles With More Than Two Heteromentioning

confidence: 99%

Microwave Assisted Reactions of Azaheterocycles Formedicinal Chemistry Applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Following the successful introduction, inspired by the biological profile of triazoles, thiazolidinones, and in the continuation of our work on biologically active heterocycles [37][38][39][40][41][42][43][44][45][46] we have developed a series of novel triazolyl thiazolidine derivatives of pyrene, and evaluated their anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Synthesis and Anticancer Activity of Triazolyl Thiazolidine Derivatives of Pyrene

Avula

Karthik²,

Sunitha³

et al. 2019

ACSi

Self Cite

View full text Add to dashboard Cite

In a one pot procedure a series of (R)-2-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-3-phenylthiazolidin-4-ones 9a-g and 2-((2R)-2-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-4-oxo-3-phenylthiazolidin-5-yl)acetic acids 10a-g was prepared by condensation of (2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-carbaldehyde with mercapto acids and primary amines in the presence of ZnCl 2 under both microwave irradiation and conventional heating conditions. Characterization of new compounds has been done by means of IR, NMR, MS and elemental analysis. The cytotoxicity was assessed against a panel of four different human tumor cell lines: A549 derived from human alveolar adenocarcinoma epithelial cells (ATCC No. CCL-185), Hela derived from human cervical cancer cells (ATCC No. CCL-2), MDA-MB-231 derived from human breast adenocarcinoma cells (ATCC No. HTB22) and HEK 293 (normal human embryonic kidney cell line) using the MTT assays. Among the tested compounds 9e and 10e showed the most potent activity against MCF-7 breast cancer cell line with IC 50 values of 1.91 and 1.95 μΜ, whereas 9b, 10b, 9g and 10g showed promising activity against MDA-MB-231 and Hela cell lines with IC 50 values of 5.84, 5.74, 7.89 and 7.65 μΜ, respectively.

show abstract

“…Numerous publications report the combination of water as an environmentally benign solvent for chemical transformations with the use of MW irradiation as an efficient heating method. 19,20 In fact, MW heating has become a broadly accepted non-conventional energy source for performing organic synthesis [21][22][23][24][25][26][27][28][29] as well as in various aspects of inorganic chemistry and polymer chemistry. 30,31 Microwave heating is preferred in the context of environmentally benign synthesis because it is a more homogenous method and accelerates reaction processes as compared to the traditional heating methods (e.g.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Bromo Organic Molecules and Investigations on Their Antibacterial Properties: An Experimental and Computational Approach

Longkumer

Richa

Karmaker

et al. 2019

ACSi

View full text Add to dashboard Cite

A simple, environmentally benign methodology has been developed to synthesize some bromoorganic compounds which have potential as antimicrobial agents. The required compounds were obtained through microwave (MW) irradiation, on-water reactions and using cetyltrimethylammonium tribromide (CTMATB) as the bromine source. The high yield of the product could be achieved within short reaction times, thus representing the main attribute of the present synthetic approach. The compounds were evaluated for in vitro antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Bacillus subtilis. Further, in silico studies were carried out to elucidate the interactions of the compounds with the bacterial proteins.

show abstract

Microwave-assisted Synthesis of Hybrid Heterocycles as Potential Anticancer Agents

Cited by 11 publications

References 19 publications

Microwave Assisted Reactions of Azaheterocycles Formedicinal Chemistry Applications

Microwave Assisted Reactions of Azaheterocycles Formedicinal Chemistry Applications

Microwave-Assisted Synthesis and Anticancer Activity of Triazolyl Thiazolidine Derivatives of Pyrene

Green Synthesis of Bromo Organic Molecules and Investigations on Their Antibacterial Properties: An Experimental and Computational Approach

Contact Info

Product

Resources

About