Microwave-assisted synthesis of rhodamine derivatives

Microwave‐Assisted Syntheses of Rhodamine, Rhodol, and Fluorescein Derivatives

“…General Methods for the aminolysis by microwave-assisted synthesis: fluorescein methyl ester (5 b, 0.1 mmol, 33 mg) was intro-duced in a 5 mL microwave-resistant flask and solubilized in EtOH (1.5 mL) together with the corresponding amine (10 eq) and heated to 80 °C for 30' three times in a row. [14,22] TLC analyses were performed in DCM/MeOH 98 : 2 v/v while the corresponding product was isolated through silica gel flash chromatography using a DCM/MeOH step-gradient (100 %!80 % DCM/MeOH v/v).…”

“…This research aims to complement what we have previously reported a for electron withdrawing amines such as cyanamide. [8] Our synthetic methodology, using microwave assisted synthesis [14] results in increased yields for all the compounds tested, while strongly reducing the reaction times. [8,14]…”

“…[8] Our synthetic methodology, using microwave assisted synthesis [14] results in increased yields for all the compounds tested, while strongly reducing the reaction times. [8,14]…”

Green Synthesis, Characterization and Photophysical Properties of Rhodamine Derivatives

“…Microwave application in organic synthesis has had exponential growth over the last twenty years due to its easy experimental conditions, rapid turnaround, and easy workups. Moreover, it is considered environmentally friendly and typically offers high yields, along with simplified processing and handling compared to conventional synthesis methods [14] [15] [16]. Microwave irradiation technique possesses several green attributes such as increased energy efficiencies, less purification process, cleanliness, and use of green solvents.…”