Microwave Hyperthermia in Conjunction with Radiotherapy in Superficial Tumours: Correlation of Thermal Parameters with Tumour Regression

Kouloulias,; Triantopoulou, Sotiria; Efstathopoulos, Efstathios; Platoni, Kalliopi; Kouvaris, John; Uzunöglou, N.; Antypas, Christos; Karaiskos, P.; Aggelakis, P; Vrouvas, J.; Kelekis, Nikolaos

doi:10.7727/wimj.2012.328

Cited by 4 publications

(4 citation statements)

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“…Numerous clinical data have suggested that microwave (MW) ablation can improve the oncologic outcomes of patients with hepatocellular carcinoma ( 7 ), colorectal liver metastases ( 8 ) and recurrent colorectal lung metastases ( 9 ). MW hyperthermia (temperature usually ranges between 42 and 45°C) has been widely employed in clinical trials of superficial tumors, including head and neck cancer, or breast cancer recurrences to the chest wall ( 10 – 13 ). It can also be used effectively in conjunction with radiation therapy and chemotherapy, and promotes body's immune response to fight against the target tumor ( 14 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

Microwave hyperthermia promotes caspase‑3-dependent apoptosis and induces G2/M checkpoint arrest via the ATM pathway in non‑small cell lung cancer cells

Zhao

et al. 2018

Int J Oncol

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Post-operative microwave (MW) hyperthermia has been applied as an important adjuvant therapy to enhance the efficacy of traditional cancer treatment. A better understanding of the molecular mechanisms of MW hyperthermia may provide guided and further information on clinical hyperthermia treatment. In this study, we examined the effects of MW hyperthermia on non-small cell lung carcinoma (NSCLC) cells in vitro, as well as the underlying mechanisms. In order to mimic clinical treatment, we developed special MW heating equipment for this study. Various NSCLC cells (H460, PC-9 and H1975) were exposed to hyperthermia treatment using a water bath or MW heating system. The results revealed that MW hyperthermia significantly inhibited cell growth compared with the water bath heating system. Furthermore, MW hyperthermia increased the production of reactive oxygen species (ROS), decreased the levels of mitochondrial membrane potential (MMP) and induced caspase-3 dependent apoptosis. It also induced G2/M phase arrest through the upregulation of the expression of phosphorylated (p-) ataxia telangiectasia mutated (ATM), p-checkpoint kinase 2 (Chk2) and p21, and the downregulation of the expression of cdc25c, cyclin B1 and cdc2. On the whole, the findings of this study indicate that the exposure of NSCLC cells to MW hyper-thermia promotes caspase-3 dependent apoptosis and induces G2/M cell cycle arrest via the ATM pathway. This preclinical study may help to provide laboratory-based evidence for MW hyperthermia treatment in clinical practice.

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Section: Introductionmentioning

confidence: 99%

Microwave hyperthermia promotes caspase‑3-dependent apoptosis and induces G2/M checkpoint arrest via the ATM pathway in non‑small cell lung cancer cells

Zhao

et al. 2018

Int J Oncol

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“…The measurements were made using a hyperthermic microwave system 433 MHz, consisting of three main parts: a power unit, a microwave signal generator, and two amplifiers. [ 9 10 ] All experiments were performed for output MW maximum power equal to 100 W. The distribution of the temperature along the applicator was measured with an invasive thermometer implanted in the selected points of measurements (separated by 1 cm) in the soft-tissue phantom box [ Figure 4 ]. SAR measurements separated by 1 cm were also made at same selected points at three different areas at 1, 2, and 3 cm depth, respectively, inside the phantom, below and along the central region (plane) of the applicator, with respect to all selected points within the corresponding regions.…”

Section: S Ubjects and M Ethodsmentioning

confidence: 99%

Documentation of a new intracavitary applicator for transrectal hyperthermia designed for prostate cancer cases: A phantom study

et al. 2018

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“…The CR rate was 66.1% in HT combined with radiotherapy group and 42.3% in radiotherapy group. Kouloulias group [ 54 ] showed that 60% of the patients with 20 superficial tumors, including submandibular lymph nodes from head and neck cancers, had a complete response and microwave heating should be over 44 °C for favourable treatment response, when combined with radiotherapy.…”

Section: Clinical Application Of Local Hyperthermia In Head and Neck mentioning

confidence: 99%

Local hyperthermia in head and neck cancer: mechanism, application and advance

et al. 2016

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Local hyperthermia (HT), particularly in conjunction with surgery, radiotherapy and chemotherapy was useful for the treatment of human malignant tumors including head and neck cancer. However, at present it suffered from many limitations such as thermal dose control, target treatment regions and discrimination between healthy and cancer cells. Recent developments in nanotechnology have introduced novel and smart therapeutic nanomaterials to local HT of head and neck cancer that basically take advantage of various targeting approaches. The aim of this paper is to give a brief review of the mechanism, methods and clinical applications of local HT in head and neck cancer, mainly focusing on photothermal therapy (PTT) and nanoparticlebased hyperthermia.

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Microwave Hyperthermia in Conjunction with Radiotherapy in Superficial Tumours: Correlation of Thermal Parameters with Tumour Regression

Abstract: Microwave heating should be over 44 °C for favourable treatment response, when combined with radiotherapy. More patients are needed to confirm the above results.

Cited by 4 publications

References 24 publications

Microwave hyperthermia promotes caspase‑3-dependent apoptosis and induces G2/M checkpoint arrest via the ATM pathway in non‑small cell lung cancer cells

Microwave hyperthermia promotes caspase‑3-dependent apoptosis and induces G2/M checkpoint arrest via the ATM pathway in non‑small cell lung cancer cells

Documentation of a new intracavitary applicator for transrectal hyperthermia designed for prostate cancer cases: A phantom study

Local hyperthermia in head and neck cancer: mechanism, application and advance

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