Microwaves for menorrhagia: a new fast technique for endometrial ablation

Sharp, Nicholas; Hodgson, David A.; Cronin, N. J.; Feldberg, I; Evans, M.; Ellis, Scott J.

doi:10.1016/s0140-6736(95)91689-x

Cited by 119 publications

(77 citation statements)

References 3 publications

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“…12 These near-field applicators can be made much smaller than the wavelength, but require 30-to 100-W incident power due to the extremely low radiation efficiency. [23][24][25] The use of higher frequency microwaves mitigates the problems of impedance mismatch and wave reflection, which result in enhanced ablation efficiencies as demonstrated in our work. From Figure 6, the high-frequency band edge from 20 to 24 GHz can be another candidate frequency range due to the large difference in the dielectric losses.…”

Section: Discussionmentioning

confidence: 66%

High‐frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage

Yoon

Cho

Kim

et al. 2011

Intl Journal of Cancer

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To overcome the limits of conventional microwave ablation, a new frequency spectrum above 6 GHz has been explored for low-power and low collateral damage ablation procedure. A planar coaxial probe-based applicator, suitable for easy insertion into the human body, was developed for our study to cover a wideband frequency up to 30 GHz. Thermal ablations with small input power (1-3 W) at various microwave frequencies were performed on nude mice xenografted with human breast cancer. Comparative study of ablation efficiencies revealed that 18-GHz microwave results in the largest difference in the temperature rise between cancer and normal tissues as well as the highest ablation efficiency, reaching 20 times that of 2 GHz. Thermal profile study on the composite region of cancer and fat also showed significantly reduced collateral damage using 18 GHz. Application of low-power (1 W) 18-GHz microwave on the nude mice xenografted with human breast cancer cells resulted in recurrence-free treatment. The proposed microwave ablation method can be a very effective process to treat small-sized tumor with minimized invasiveness and collateral damages.Breast cancer is a major threat to women's health psychologically as well as physically. 1 Despite the high potential of fatality, most women show reluctance for large-scale breast removal due to cosmetic concerns, which brings about the need for local surgical control. For this reason, minimally invasive techniques to achieve better local surgical control have collected extensive attention as a possible first-line treatment in lieu of conservative breast surgery procedures such as lumpectomy. 2,3 Among several alternative methods, microwave ablation entails many benefits in comparison with the others such as laser ablation, cryoablation and ethanol ablation. [4][5][6][7][8] Microwave ablation method is much safer and easily manageable 9 and can, in principle, offer material-specific responsiveness, where tissues with high water content such as cancer are preferentially heated and damaged. 10,11 This characteristic of microwaves makes microwave ablation well suited for local treatment of early stage of breast cancer. So far, the frequencies used in the existing microwave ablation systems have been limited to the low-frequency spectrum such as 915 MHz or 2.4 GHz. Because of the inherent low radiation efficiency, very high microwave input power of several tens of Watts is required at these frequencies, thus greatly increasing the cost and size of the equipment. 12 Moreover, because of the self-heating of the applicator by the excessive microwave power, additional means for cooling the applicator are required to avoid the damage of healthy tissues near the passage of the applicator. 13 Besides, the conventional low-frequency spectrum ablation has poor material selectivity when compared to the alternative high-frequency spectrum proposed in our work.To overcome the limitations of the existing microwave ablation methods, we have investigated the properties of microwaves up to 30 GHz wit...

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Section: Discussionmentioning

confidence: 66%

High‐frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage

Yoon

Cho

Kim

et al. 2011

Intl Journal of Cancer

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“…An 8-mm applicator inserted through the cervix delivers the microwaves using a dielectrically loaded waveguide. 62 Power is controlled by the surgeon using a footswitch and the temperature inside the uterus is monitored by thermocouples on the surface of the waveguide. Prior to microwave ablation treatment, oral and vaginal thinning agents may be given.…”

Section: Microwave Endometrial Ablationmentioning

confidence: 99%

Hysterectomy, endometrial ablation and Mirena® for heavy menstrual bleeding: a systematic review of clinical effectiveness and cost-effectiveness analysis

Bhattacharya

Middleton²,

Tsourapas³

et al. 2011

Health Technol Assess

100

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of project...

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“…Microwave endometrial ablation (MEA®) Sharp et al [62] first developed in 1995 the use of microwave energy for the treatment of abnormal uterine bleeding. Microwave energy of 9.2 GHz is generated in a magnetron and is applicated by a probe within the endometrial cavity.…”

Section: Second-generation Endometrial Ablation Techniquesmentioning

confidence: 99%

Treatment options for dysfunctional uterine bleeding: evaluation of clinical results

et al. 2011

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Abnormal uterine bleeding is one of the most common problems in women of reproductive age, and dysfunctional uterine bleeding (DUB) accounts for about half the cases. The aim of this review is to present all treatment options for women suffering from DUB and to evaluate their effectiveness. A detailed search strategy on electronic databases was carried out to identify trials and reviews on management of abnormal uterine bleeding. Tranexamic acid is the most effective medical treatment. A levonorgestrel-releasing intrauterine device is a low-cost, simple, and effective medical method, comparable to hysterectomy in terms of quality of life. In cases of DUB resistant to medical treatment, surgical treatment should be offered. First-generation ablation techniques are effective, but have a long learning curve. Second-generation ablation devices are highly effective and safe alternatives, thoroughly compared to first-generation techniques. Hysterectomy is the only method that guarantees treatment of dysfunctional uterine bleeding, but is a major operation associated with higher morbidity and mortality rates. Proper counseling of each woman with DUB regarding all treatment modalities can provide the best choice for each patient. More prospective randomized trials are needed to establish the effectiveness of these methods

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Microwaves for menorrhagia: a new fast technique for endometrial ablation

Cited by 119 publications

References 3 publications

High‐frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage

High‐frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage

Hysterectomy, endometrial ablation and Mirena® for heavy menstrual bleeding: a systematic review of clinical effectiveness and cost-effectiveness analysis

Treatment options for dysfunctional uterine bleeding: evaluation of clinical results

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