Mid and long-term overall survival after carcinologic resections of thyroid cancer bone metastases

Fragnaud, Henri; Mattei, Jean-Camille; Nail, Louis-Romée Le; Nguyễn, Mỹ-Vân; Schubert, Thomas; Griffin, Anthony M.; Wunder, Jay S.; Biau, David; Bonnevialle, P.; Vaz, Gualter; Ropars, M.; Crenn, Vincent

doi:10.3389/fsurg.2022.965951

Cited by 6 publications

(6 citation statements)

References 27 publications

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“…In terms of long-term oncological outcomes for patients who underwent radical resection of bone metastases from DTC, in the multicentric retrospective study conducted by Fragnaud et al, overall survival for patients who underwent wide resection at 1, 5, 10, and 15 years was 76.2%, 63.6%, 63.6%, and 31.8%, respectively [ 15 ]. This study described much higher overall survival rates in comparison to the studies of Nakayama et al and Satcher et al [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…This study described much higher overall survival rates in comparison to the studies of Nakayama et al and Satcher et al [ 16 , 17 ]. Moreover, Fragnaud et al demonstrated that R0 and R1 resections were associated with a better prognosis compared to R2 resection, whereas the overall survival was extremely higher (82.3% vs 0%) when a resection of isolated bone metastasis was performed in comparison to patients with multi-metastatic bone lesions [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

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Synchronous Sternal Metastasectomy and Total Thyroidectomy for Differentiated Thyroid Cancer: A Rare Case Report

Πασπάλα¹,

Papakonstantinou²,

Pikoulis³

et al. 2022

Cureus

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Bone metastases from thyroid cancer are mainly rare, while sternal metastases are extremely uncommon. Bone metastases might be either synchronous or metachronous to primary thyroid cancer. A 60-year-old male patient presented to our department with a painful, fixed and firm sternal mass. Preoperative imaging studies, such as neck ultrasound (US) and computed tomography (CT) of the chest, revealed a 6.5 cm nodule of the right thyroid lobe with high-risk malignancy characteristics and a massive metastatic mass of the anterior mediastinal, which was extended from the sternal notch to the third intercostal space. The diagnosis of papillary thyroid carcinoma with sternal metastatic lesions was established. After meticulous discussion in the multidisciplinary board of our hospital, a total thyroidectomy plus en-bloc resection of this massive sternal metastasis and adjuvant radioiodine therapy were decided. Eight months postoperatively, no recurrence has occurred in this patient. R0 resection of isolated bone metastasis of thyroid origin is still an optimal therapeutic decision for these patients. In cases of sternal metastasis, radical surgical resection with negative margins, including both resection of the lesion and reconstruction of the chest wall, in order to successfully maintain the chest wall's stability, is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Synchronous Sternal Metastasectomy and Total Thyroidectomy for Differentiated Thyroid Cancer: A Rare Case Report

Πασπάλα¹,

Papakonstantinou²,

Pikoulis³

et al. 2022

Cureus

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“…With regard to patients with metastatic thyroid carcinoma to the appendicular skeleton, wide resection of solitary bone lesions have improved rates of survival, regardless of tumor subtype. [57][58][59][60] This is an important consideration as metastatic thyroid cancer may be less responsive to radiation and systemic therapy. 61,62 There is also data to suggest that resection of up to five osseous metastatic foci with negative margins also prolongs survival.…”

Section: Thyroid Carcinomamentioning

confidence: 99%

Metastasectomy for oligometastatic bone disease of the appendicular skeleton: A concise review

Kafchinski

2023

Journal of Surgical Oncology

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As the life expectancy of patients with carcinomas improves, there is an associated increase in the risk of development of metastatic bone disease. Patients with solitary or oligometastatic bone disease of the appendicular skeleton may benefit from metastasectomy and reconstruction to improve overall survival. Specifically, patients with renal cell carcinoma and a solitary metastatic bone lesion will have long‐term survival benefit from metastasectomy and reconstruction. There remains controversy in the literature about metastasectomy for solitary metastatic bone disease in other common carcinomas, such as breast and thyroid.

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“…Они плохо отвечают на радиойодтерапию, и полная ремиссия костных метастазов составляет всего лишь 10-17 %. 8,9].…”

Section: Introductionunclassified

PET/CT with <sup>18</sup>F-FDG for TENIS Syndrome in a Patient with Bone Metastasis of Hurthle Cell Thyroid Cancer: a Clinical Case Report

Li,

Geliashvili,

Sushencov

et al. 2024

jour

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A significant role in improving the prognosis of differentiated thyroid cancer (DTC) in the presence of bone metastases is determined by early diagnosis of metastases, timely and correctly selected treatment tactics for the patient. During dynamic follow-up of patients with DTC after combined treatment (thyroidectomy with radioiodine therapy) are determination of the level of oncomarkers (serum thyroglobulin and antibodies to thyroglobulin) and ultrasound diagnostic of the neck, scanning with radioactive iodine (if clinically indicated). In some cases, patients have TENIS-syndrome (Thyroglobulin Elevated Negative Iodine Scintigraphy, hereinafter TENIS-syndrome), characterized by high serum thyroglobulin level in blood and absence of radioactive iodine accumulation on post therapeutic scintigraphy. According to the research studies, PET/CT with 18F-FDG has high sensitivity and specificity (89 % and 72 %, respectively) in visualization of metastatic radioiodine refractory foci in TENIS-syndrome.This article presents a clinical case of a patient, a 52-year-old woman with Gurtle cell thyroid cancer (pT3aN0M0, stage I) with established TENIS syndrome. Thyroidectomy was performed in September 2019 and radioiodine therapy was performed in January 2022 due to suspected disease progression given high thyroglobulin levels. Given the absence of pathologic accumulation of 131I according to post-therapy radioiodine scanning, PET/CT with 18F-FDG was performed, which revealed a solitary metastasis in the left iliac bone (41×35×42 mm with SUVmax 17.25). In November 2022, radical treatment of the solitary bone metastasis was performed in the scope of resection of the left iliac bone with reconstructive-plastic component. According to the data of control examinations in June 2023, the patient has a complete biochemical and radiologic remission of the disease.

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Mid and long-term overall survival after carcinologic resections of thyroid cancer bone metastases

Cited by 6 publications

References 27 publications

Synchronous Sternal Metastasectomy and Total Thyroidectomy for Differentiated Thyroid Cancer: A Rare Case Report

Synchronous Sternal Metastasectomy and Total Thyroidectomy for Differentiated Thyroid Cancer: A Rare Case Report

Metastasectomy for oligometastatic bone disease of the appendicular skeleton: A concise review

PET/CT with <sup>18</sup>F-FDG for TENIS Syndrome in a Patient with Bone Metastasis of Hurthle Cell Thyroid Cancer: a Clinical Case Report

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