Mid-second Trimester Measurement of Nasal Bone Length in the Indian Population

Narayani, Bandeppa H; Radhakrishnan, Prathima

doi:10.1007/s13224-012-0335-5

Cited by 16 publications

(24 citation statements)

References 14 publications

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“…Following the criteria of measurement, a normal Vietnamese reference for fetal NBL at 19–26 weeks’ gestation was identified. Fetal NBL increases significantly with gestational age and BPD, in accordance with previous monosonographer reports . The present 50th percentile of fetal NBL was longer than that noted by Narayani and Radhakrishnan in India, but it was closely matched by Kanagawa et al .…”

Section: Discussionsupporting

confidence: 92%

“…At the second trimester of gestation, there is a higher proportion of nasal bone in the total volume of osteo‐cartilaginous tissue in the fetus with normal karyotype than in Down syndrome fetuses (the ratio is 35–50% of bone tissue in fetal euploidy versus 10–20% in trisomy 21) . Several studies have proposed an association between delayed ossification of fetal nasal bone and Down syndrome, but delayed maturation has also been noted in fetuses without abnormalities, depending on maternal ethnicity …”

Section: Discussionmentioning

confidence: 99%

“…This dilemma could make pregnant women anxious, resulting in an increased number of unwarranted amniocenteses to rule out fetal Down syndrome. The determination of nasal bone hypoplasia requires the knowledge of the normative data for fetal NBL across gestational age and maternal ethnicity …”

Section: Discussionmentioning

confidence: 99%

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Fetal nasal bone length at 19–26 weeks’ gestation in Vietnam

Tomai

Phan

2016

J of Obstet and Gynaecol

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Aim The purpose of this study was to establish the normal range of fetal nasal bone length (NBL) at the second trimester of gestation in Vietnamese pregnancies. Methods A prospective cross‐sectional study was carried out. A total of 2432 singleton pregnancies were evaluated for fetal NBL at 19–26 weeks 6 days between 1 January 2013 and 31 December 2014. Three measurements of NBL were taken and the largest value was chosen. Fetal anomalies and neonatal abnormalities were excluded. Results Mean fetal NBL was 6.75 ± 0.82 mm and mean gestational age was 22.2 ± 1.4 weeks. Median NBL increased linearly with advancing gestational age: NBL (mm) = 0.26 × gestational age (weeks) + 1.03 (R2 = 0.20; P < 0.000). The fifth percentile of fetal NBL ranged from 4.6 to 6.3 mm, corresponding with gestational age 19–26 weeks. Conclusion The normal range of NBL was established at second trimester in Vietnamese pregnancies. NBL at the fifth percentile for gestational age was different from that of other Asian ethnicities. It is necessary to define short NBL or hypoplasia of NBL with regard to ethnicity.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Fetal nasal bone length at 19–26 weeks’ gestation in Vietnam

Tomai

Phan

2016

J of Obstet and Gynaecol

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“…Mid-second trimester foetal nasal bone measurements in healthy Chinese population was shorter than in White and Black population. Bundeppa et al (2) have also observed that race and ethnicity have an impact on foetal bone length.…”

Section: Discussionmentioning

confidence: 94%

“…4 gives comparative values of nasal bone length in foetuses of North Indian and South Indian. (2) Caucasian. (1) , Brazilian.…”

Section: Discussionmentioning

confidence: 99%

Study of Foetal Nasal Bone Length During 15-38 Weeks of Gestation in Women of Northern India (U.P.) and Its Comparison With Western and Other Asian Women

Gupta¹,

Gupta²,

Saxena³

et al. 2016

jemds

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Foetal nasal bone length vary in different ethnic groups, its rate of growth in a particular group can be accurately measured. This increase in foetal nasal bone length can be used as a reference range for that particular group. OBJECTIVEThis study is an attempt to evaluate a reference range of foetal nasal bone length from 15 wks. to full term in North Indian population and to find the difference with other ethnic groups during the same period of gestation. MATERIAL AND METHODPregnant women undergoing ultrasonography from 15 wks. till term with a single live foetus having no complication either in the foetus or mother were selected for the study. All parameters i.e. BPD, AC, FL, kidney length, nasal bone length measurements and their rate of growth were calculated and findings were compared with other authors. RESULTSThe rate of growth of foetal nasal bone length during different weeks of gestation showed correlation described by the following equation NBL=0.349XGA+0.440 with goodness of fit estimate R 2 =0.969 with a constant p value <0.0001. There was a significant difference in length of foetal nasal bone length in different ethnic groups. Our results in North Indian population were similar to that of South Indian, Caucasians, Brazilian population, but very different from that of Chinese and Japanese population. CONCLUSIONThe data can be used in estimation of GA by NBL as the estimation of NBL is accurate and the increase per week of gestation shows a linear increase in Indian population. KEYWORDSFoetal Nasal Bone, Normal Range, North Indian Women. HOW TO CITE THIS ARTICLE:Gupta DP, Gupta RP, Saxena DK, et al. Study of foetal nasal bone length during 15-38 weeks of gestation in women of Northern India (U.P.) and its comparison with Western and other Asian women.

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Absent or hypoplastic nasal bone: What to tell the prospective parents?

Das,

Sharma,

Yadav

et al. 2024

Birth Defects Research

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BackgroundAbsent or hypoplastic nasal bone (AHNB) on first or second‐trimester ultrasonography (USG) is an important soft marker of Down syndrome. However, due to its varied incidence in euploid and aneuploid fetuses, there is always a dilemma of whether to go for invasive fetal testing for isolated AHNB. This study aims to assess outcomes specifically within the context of Indian ethnicity women.Materials and MethodsThis was a prospective observational study. All patients who reported with AHNB in the first‐ or second‐trimester USG were included. Genetic counseling was done, and noninvasive and invasive testing was offered. Chromosomal anomalies were meticulously recorded, and pregnancy was monitored.ResultsThe incidence of AHNB in our study was 1.16% (47/4051). Out of 47 women with AHNB, the isolated condition was seen in 32 (0.78%) cases, while AHNB with structural anomalies was seen in nine cases (0.22%). Thirty‐nine women opted for invasive testing. Six out of 47 had aneuploidy (12.7%), while two euploid cases (4.25%) developed nonimmune hydrops. The prevalence of Down syndrome in fetuses with AHNB was 8.5% (4/47) and 0.42% (17/4004) in fetuses with nasal bone present. This difference was statistically significant (p = .001).ConclusionThe results indicate that isolated AHNB cases should be followed by a comprehensive anomaly scan rather than immediately recommending invasive testing. However, invasive testing is required when AHNB is associated with other soft markers or abnormalities. As chromosomal microarray is more sensitive than standard karyotype in detecting chromosomal aberrations, it should be chosen over karyotype.

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Mid-second Trimester Measurement of Nasal Bone Length in the Indian Population

Cited by 16 publications

References 14 publications

Fetal nasal bone length at 19–26 weeks’ gestation in Vietnam

Fetal nasal bone length at 19–26 weeks’ gestation in Vietnam

Study of Foetal Nasal Bone Length During 15-38 Weeks of Gestation in Women of Northern India (U.P.) and Its Comparison With Western and Other Asian Women

Absent or hypoplastic nasal bone: What to tell the prospective parents?

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