Mid-term Effects of Sleeve Gastrectomy on Calcium Metabolism Parameters, Vitamin D and Parathormone (PTH) in Morbid Obese Women

Ruíz-Tóvar, Jaime; Oller, Inmaculada; Tomás, A.; Llavero, Carolina; Arroyo, Antonio; Calero, Alicia; Martinez-Blasco, Amparo; Calpena, Rafael

doi:10.1007/s11695-011-0582-z

Cited by 49 publications

(27 citation statements)

References 22 publications

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“…According to the literature, the level of PTH in the blood after bariatric surgery can change in the direction of its decrease or increase [25][26][27]. In our study, we note a signifi cant decrease in PTH levels starting from the 3rd month of observation, which is in weak negative correlation with VTD, BMI and FAT.…”

Section: Discussionsupporting

confidence: 61%

Bone Metabolism Changes after Laparoscopic Greater Curvature Plication. A One-Year Study.

Nykonenko

Gaidarzhi

Bužga

2016

ZMJ

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In addition to the positive effect of weight loosing after bariatric surgery, the post-operative period is often associated with signifi cant changes in bone metabolism.Aim. The aim of this study was to examine changes in bone turnover markers and indicators of dual-energy X-ray absorptiometry (DXA) within 12 months after laparoscopic greater curvature plication (LGCP).Materials and methods. We studied 54 patients from class III obesity who underwent LGCP. The average preoperative weight of the patients was 125.5±19.1 kg, and BMI of 43.0±4.9 kg/m 2 . The gender distribution of the cohort was 35.2% man and 64.8% women. At three time points after the operation (at 3, 6 and 12 months) control examination was conducted that included DXA and markers of bone metabolism.Results. After the surgical treatment we registered signifi cant reduction of all the anthropometric indicators (ρ<0.05; EWL 12 45.8±18.8%; EBL 12 55.1±23.4%). According to the controlled studies on the 12th months, a signifi cant increase in bone turnover markers was revealed (ρ<0.05; CTX, P1NP, OC, OPG, VTD) and reducing of PTH (ρ<0.05). The measure of DXA on the 12th month of observation showed no signifi cant changes in bone metabolism. Strong positive correlation was uncovered between markers of bone metabolism: CTX / P1NP (r=0.790, p=0.000), CTX/ OC, P1NP/OC (r=0.7, p=0.000), minor correlation between PTH/OC (r=0.249, p=0.027). We also report a minor and weak negative correlation between the markers of bone metabolism (CTX, P1NP, OC and VTD) and anthropometric data.Conclusions. Twelve months post LGCP markers of bone turnover (CTX, P1NP, OC, OPG, VTD) were signifi cantly increased. The increased level of VTD is associated with the loss of FAT. Also the change in DXA was detected. Зміни кісткового метаболізму після лапароскопічної плікації великої кривизни шлунка. Річне дослідження А. О. Никоненко, Є. І. Гайдаржі, М. БужґаНезважаючи на позитивний ефект втрати ваги після баріатричних операцій, післяопераційний період часто пов'язаний зі значними змінами в метаболізмі кісткової тканини.Мета роботи -вивчення динаміки маркерів ремоделювання кістки та показників її двоенергетичної рентгенівської абсорбціометрії протягом 12 місяців після лапароскопічної плікації великої кривизни шлунка.Матеріали та методи. Досліджували 54 пацієнти з ожирінням III ступеня, які перенесли лапароскопічну плікацію великої кри-визни шлунка. Середня передопераційна вага пацієнтів була 125,5±19,1 кг і ІМТ 43,0±4,9 кг/м 2 . Поділ за статтю був такий: 35,2% чоловіків і 64,8% жінок. Контрольне обстеження здійснили на 3, 6 і 12 місяці після операції. Обстеження включало вимір показників двоенергетичної рентгенівської абсорбціометрії та визначення маркерів кісткового метаболізму.Результати. Після хірургічного лікування зареєстрували значне зниження всіх антропометричних показників (ρ<0,05; EWL 12 45,8±18,8%; EBL 12 55,1±23,4%). Згідно з результатами досліджень через 12 місяців виявили значне збільшення маркерів ремоделювання кістки (ρ<0,05; CTX, P1NP, OC, OPG, VTD) та зниження PTH (ρ...

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Section: Discussionsupporting

confidence: 61%

Bone Metabolism Changes after Laparoscopic Greater Curvature Plication. A One-Year Study.

Nykonenko

Gaidarzhi

Bužga

2016

ZMJ

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“…After diet-and exercise-induced weight loss, both increased 9-11 and unaltered 12,13 circulating levels of 25OHD have been reported. Likewise, after major weight loss by bariatric surgery, both temporary 14-16 and long-term increases [16][17][18] in circulating levels of 25OHD have been reported, along with reports of no changes one year after surgery. 13,19 Taken together, these findings indicate that body weight is an important factor for circulating 25OHD levels.…”

mentioning

confidence: 97%

Expression of vitamin D-metabolizing enzymes in human adipose tissue—the effect of obesity and diet-induced weight loss

et al. 2012

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OBJECTIVE: Low vitamin D (VD) levels are common in obesity. We hypothesized that this may be due to metabolism of VD in adipose tissue (AT). Thus, we studied (1) whether the VD-metabolizing enzymes were expressed differently in AT of lean and obese individuals and in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), and (2) whether their expression was influenced by weight loss. METHODS: Samples of SAT and VAT were analyzed for expression of the vitamin-D-25-hydroxylases CYP2R1, CYP2J2, CYP27A1 and CYP3A4, the 25-vitamin-D-1a-hydroxylase CYP27B1, the catabolic vitamin-D-24-hydroxylase CYP24A1, and the vitamin D receptor, using reverse transcriptase-PCR. Moreover, plasma 25-hydroxy-vitamin D (25OHD) level was measured and related to the expression of these enzymes. Samples of SAT and VAT from 20 lean women and 20 obese women, and samples of SAT from 17 obese subjects before and after a 10% weight loss were analyzed. RESULTS: A plasma 25OHD level o50 nmol l À 1 was highly prevalent in both lean (45%) and obese (90%) women (Po0.01). Plasma 25OHD increased by 27% after weight loss in the obese individuals (Po0.05). Expression levels of the 25-hydroxylase CYP2J2 and the 1a-hydroxylase CYP27B1 were decreased by 71% (Po0.0001) and 49% (Po0.05), respectively, in SAT of the obese. CYP24A1 did not differ between lean and obese women, but the expression was increased by 79% (Po0.05) after weight loss. CONCLUSION: Obesity is characterized by a decreased expression of the 25-hydroxylase CYP2J2 and the 1a-hydroxylase CYP27B1 in SAT, whereas the catabolic CYP24A1 does not differ between lean and obese women. However, the expression of CYP24A1 is increased after weight loss. Accordingly, AT has the capacity to metabolize VD locally, and this can be dynamically altered during obesity and weight loss. INTRODUCTIONLow levels of circulating 25-hydroxy-vitamin D (25OHD) are associated with increased fat mass and body mass index, 1-5 but the underlying mechanism for this association is not fully elucidated. 6 Vitamin D (VD) is stored in adipose tissue (AT), and release of VD from AT is proposed to serve as an endogenous source of VD during the winter, when cutaneous production is low or absent in several parts of the world. 7 As low circulating levels of 25OHD are common in association with the obese state, 8 several studies have examined the effect of weight loss on circulating levels of 25OHD. However, results are inconsistent. After diet-and exercise-induced weight loss, both increased 9-11 and unaltered 12,13 circulating levels of 25OHD have been reported. Likewise, after major weight loss by bariatric surgery, both temporary 14-16 and long-term increases [16][17][18] in circulating levels of 25OHD have been reported, along with reports of no changes one year after surgery. 13,19 Taken together, these findings indicate that body weight is an important factor for circulating 25OHD levels. Several other explanations for the low levels of 25OHD in obesity have been proposed: a decreased exposure to sun light, 20 ...

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“…DIET, SUPPLEMENTS, AND FOODS IN THE MANAGEMENT OF VISCERAL OBESITY [26,28,30]. Our own experience showed that about a quarter of the patients who reported taking supplements developed micronutrient deficiencies [28].…”

Section: Micronutrient Supplementationmentioning

confidence: 84%

“…Interestingly, some studies showed that bariatric surgery can increase 25(OH)D serum concentrations or decrease the frequency of vitamin D deficiency [26,28,29]. This might be explained by the fact that the reduction in adiposity caused by surgery potentiates the bioavailability of vitamin D. This observation should be addressed in further studies.…”

Section: Vitamin D and Calciummentioning

confidence: 95%

“…Insufficient serum 25(OH)D is a common condition in obese subjects before bariatric surgery. Most authors indicate high levels of vitamin D deficiency in preoperative obese patients ranging from 33% to 97% [25,26]. Several studies have reported an inverse correlation between 25(OH)D serum concentration and body mass index or fat mass [27,28].…”

Section: Vitamin D and Calciummentioning

confidence: 99%

See 1 more Smart Citation

Nutritional Deficiencies in Obese Sleeve Gastrectomy Patients

Damms-Machado

Bischoff

2014

Nutrition in the Prevention and Treatment of Abdominal Obesity

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Mid-term Effects of Sleeve Gastrectomy on Calcium Metabolism Parameters, Vitamin D and Parathormone (PTH) in Morbid Obese Women

Abstract: Postoperative values of vitamin D show a progressive increase, while PTH ones present a significant reduction, without any impact on serum calcium levels. We have demonstrated an inverse correlation between weight loss and vitamin D increase at the third month after surgery.

Cited by 49 publications

References 22 publications

Bone Metabolism Changes after Laparoscopic Greater Curvature Plication. A One-Year Study.

Bone Metabolism Changes after Laparoscopic Greater Curvature Plication. A One-Year Study.

Expression of vitamin D-metabolizing enzymes in human adipose tissue—the effect of obesity and diet-induced weight loss

Nutritional Deficiencies in Obese Sleeve Gastrectomy Patients

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