Mid- to long-term outcomes of cardiovascular tissue replacements utilizing homografts harvested and stored at Japanese institutional tissue banks

Kitamura, Soichiro; Yagihara, Toshikatsu; Kobayashi, Junjiro; Nakajima, Hiroyuki; Toda, Köichi; Fujita, Tomoyuki; Ichikawa, Hajime; Ogino, Hitoshi; Nakatani, Takeshi; Taniguchi, Shigeki

doi:10.1007/s00595-010-4459-x

Cited by 15 publications

(10 citation statements)

References 31 publications

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“…In contrast, previous reports, including one from our institution, showed that full-root implantation demonstrated durability similar to or greater than that observed for subcoronary implantation. 5,22,23 One should consider several reasons for such a contrary finding. First, previous reports analyzed risk factors for reintervention, whereas this study analyzed each pathology to clarify risk factors.…”

Section: Discussionmentioning

confidence: 93%

Long-term clinical outcomes after aortic valve replacement using cryopreserved aortic allograft

Fukushima

Tesar

Pearse

et al. 2014

The Journal of Thoracic and Cardiovascular Surgery

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Section: Discussionmentioning

confidence: 93%

Long-term clinical outcomes after aortic valve replacement using cryopreserved aortic allograft

Fukushima

Tesar

Pearse

et al. 2014

The Journal of Thoracic and Cardiovascular Surgery

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“…For patients requiring revascularization surgery, unavailability of autologous bypass grafts may lead to loss of an opportunity for appropriate therapy and consequent poor prognosis. Although cryopreserved arterial allografts can be a surrogate for autologous small-caliber grafts with acceptable long-term patency, the availability is rather limited because of the shortage of donors and insufficient operation of organ / tissue banks to preserve and provide allografts [15][16][17]. The present study was designed to address this healthcare problem through validating the feasibility of xenogeneic implantation of HHP-decellularized vascular grafts using bovine arterial grafts and a porcine carotid arterial interpose model.…”

Section: Semmentioning

confidence: 99%

In vivo recellularization of xenogeneic vascular grafts decellularized with high hydrostatic pressure method in a porcine carotid arterial interpose model

Kurokawa

Hashimoto

Funamoto

et al. 2020

Preprint

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Autologous vascular grafts are widely used in revascularization surgeries for small caliber targets. However, the availability of autologous conduits might be limited due to prior surgeries or the quality of vessels. Xenogeneic decellularized vascular grafts from animals potentially substitute for autologous vascular grafts. Decellularization with high hydrostatic pressure (HHP) is reported to highly preserve extracellular matrix (ECM) which would be feasible for recellularization and vascular remodeling after implantation.In the present study, we conducted xenogeneic implantation of HHP-decellularized bovine vascular grafts from dorsalis pedis arteries to porcine carotid arteries then evaluated graft patency, ECM preservation and recellularization. Surgical procedure not to damage luminal surface of the grafts from drying significantly increased the graft patency at 4 weeks after implantation (P = 0.0079). After the technical improvement, all grafts (N = 5) were patent with mild stenosis due to intimal hyperplasia at 4 weeks after implantation. Neither aneurysmal change nor massive thrombosis was observed even without administration of anticoagulants nor anti-platelet agents. Elastica van Gieson and Sirius-red stainings revealed fair preservation of ECM proteins including elastin and collagen after implantation. Luminal surface of grafts was thoroughly covered with von Willebrand factor-positive endothelium. Scanning electron microscopy on luminal surface of implanted grafts exhibited cobblestone-like endothelial cell layer which is similar to native vascular endothelium. Recellularization of tunica media with alphasmooth muscle actin-positive smooth muscle cells was partly observed. Thus, we confirmed that HHP-decellularized grafts are feasible for xenogeneic implantation accompanied by recellularization by recipient cells. (243 words)

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“…Good long-term outcomes of aortic replacement with homograft for infectious aortic disease have been demonstrated. 5) However, in this particular reported case, we applied aortic replacement using a standard prosthetic graft due to the emergent situation under the limited availability of a homograft.…”

Section: Discussionmentioning

confidence: 99%

Organ Protection for Radical Debridement to Prevent Recurrence of Infection after Zone 1 Thoracic Endovascular Aortic Aneurysm Repair: A Case Report

Koda

Murakami

Matsuda

et al. 2020

Annals of Vascular Diseases

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We present the case of a 73-year-old man with stent graft infection, who had undergone thoracic endovascular aortic aneurysm repair with a supra-aortic bypass from the right axillary to the left common carotid and axillary arteries. The procedure included total stent graft removal, radical debridement, and in situ graft replacement via left anterolateral thoracotomy. Cerebral perfusion from the left axillary artery and cardioplegia using an occlusion balloon with moderate hypothermia were performed to reinforce organ protection. Staged omentopexy was performed the next day after initial replacement with non-contaminated instruments. The postoperative course was uneventful. No recurrence of infection has been found for 3 years.

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Mid- to long-term outcomes of cardiovascular tissue replacements utilizing homografts harvested and stored at Japanese institutional tissue banks

Cited by 15 publications

References 31 publications

Long-term clinical outcomes after aortic valve replacement using cryopreserved aortic allograft

Long-term clinical outcomes after aortic valve replacement using cryopreserved aortic allograft

In vivo recellularization of xenogeneic vascular grafts decellularized with high hydrostatic pressure method in a porcine carotid arterial interpose model

Organ Protection for Radical Debridement to Prevent Recurrence of Infection after Zone 1 Thoracic Endovascular Aortic Aneurysm Repair: A Case Report

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