Middle East Medicinal Plants in the Treatment of Diabetes: A Review

Abu-Odeh, Alaa; Talib, Wamidh H.

doi:10.3390/molecules26030742

Cited by 57 publications

(40 citation statements)

References 302 publications

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“…The best result from reduction of phosphoenolpyruvate carboxykinase (PEPCK) activity (84.0%) and increasing hepatic glycogen phosphorylase (GP) activity (134.5%) points of view was related to the aqueous extract comparing with those of glibenclamide (62.5% and 133.0%), respectively. C. bruguierana depicted no effect on blood insulin, but it was able to reduce blood glucose by stimulation of hepatic glycogenolysis and inhibition of gluconeogenesis [ 77 , 104 ].…”

Section: Resultsmentioning

confidence: 99%

“…Chlorogenic acid has chemopreventive and hypoglycemic effects [ 150 ], and it is the main component of medicinal plants characterized by their antioxidant, anti-inflammatory, and enzyme inhibitory activities [ 150 , 189 , 228 ]. C. bruguierana possessed sesquiterpene lactones and flavonoids (kaempferol, rutin, and quercetin) [ 77 , 104 , 120 ]. Also, the plant has been documented for its antiplasmodial and antipeptic ulcer effects [ 77 , 229 , 230 ].…”

Section: Discussionmentioning

confidence: 99%

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A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Fattaheian-Dehkordi

Hojjatifard

Saeedi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. Diabetes mellitus (DM) is a long-life metabolic disorder, characterized by high blood glucose levels. The hyperglycemic condition generally leads to irreversible nerve injury and vascular damage. Among different types of diabetes, type 2 is more common and has spread all over the world. Although various therapeutic approaches have been developed to control type 2 DM, regulating blood glucose levels has still remained a controversial challenge for patients. Also, most prescription drugs cause different side effects, such as gastrointestinal disorders. Thus, developing novel and efficient antidiabetic agents possessing fewer adverse effects is in high demand. Method. The literature was comprehensively surveyed via search engines such as Google Scholar, PubMed, and Scopus using appropriate keywords. Results. Medicinal plants, both extracts and isolated active components, have played a significant role in controlling the blood glucose levels. Good-to-excellent results documented in the literature have made them a precious origin for developing and designing drugs and supplements against DM. Centaurea spp. have been traditionally used for controlling high blood glucose levels. Also, the antidiabetic properties of different species of Centaurea have been confirmed in recent studies through in vitro assays as well as in vivo experiments. Conclusion. Potent results encouraged us to review their efficacy to open a new horizon for development of herbal antidiabetic agents.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Fattaheian-Dehkordi

Hojjatifard

Saeedi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Plants of chemotypes 1 (linalool content), which grow on low altitudes in Lebanon and Poland, was seen to have significantly higher acute and subchronic antidiabetic activities compared with chemotype 5 (high linalyl acetate content). Essential oils from S. sclarea demonstrated potential antidiabetic activities, and may be used as a complementary or alternative treatment of diabetes and complications that accompany it (Raafat & Habib, 2018;Pereira et al, 2019;Salehi et al, 2020;Abu-Odeh & Talib, 2021).…”

Section: Tablementioning

confidence: 99%

Effect of Salvia officinalis and S. sclarea on rats with a high-fat hypercaloric diet

Lieshchova

Bohomaz

Brygadyrenko

2021

Regul. Mech. Biosyst.

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Phytotherapy for the correction of excess body weight is widely used. However, a comprehensive study of herbal preparations on the organism of model animals has been carried out only for a few plant species. Supplementing the diet of rats with closely related sage species (Salvia officinalis L. and S. sclarea L.) against the background of high-fat hypercaloric diet triggered multidirectional changes in their metabolism. The addition of crushed dry shoots of S. officinalis to the diet of animals led to a sharp increase in their body weight (up to 130.8% of the initial one in 30 days of the experiment). The body weight of the rats treated with S. sclarea for 30 days increased only up to 103.8% of their initial weight and was lower than in the control group. Addition of S. officinalis caused an increase in daily weight gain up to 253.1% of the control group, and S. sclarea – its decrease to 27.8% of the daily weight gain in the control group. In the S. officinalis group, the relative weight of the brain, spleen, and thymus decreased, while in the S. sclarea group, the relative weight of the thymus decreased and that of the colon increased. Under the influence of S. officinalis, the concentration of urea, total bilirubin, and triglycerides in the blood plasma of male rats decreased and the concentration of total protein and the activity of alkaline phosphatase increased. While consuming S. sclarea shoots, there was an increase of alkaline phosphatase activity in the rats’ blood, but atherogenic index (23.1% of the level of the control group) sharply dropped due to an increase in the concentration of high-density lipoprotein cholesterol (286.9% of the control) and a decrease in the concentration of low-density lipoprotein cholesterol (67.7% of control). In rats feeding on S. sclarea shoots, we observed a decrease in the concentration of triglycerides in the blood (39.9% of the control), a decrease in the activity of gamma-glutamyl transferase (62.8%), and an increase in the Ca/P ratio (132.5% of the control group). No significant changes were observed in CBC and WBC differential of male rats when eating S. officinalis and S. sclarea shoots. According to the results of the open field test, the physical and orientational activity of male rats under the influence of S. officinalis significantly decreased by the end of the experiment. Emotional status of rats, on the contrary, decreased when they ate dry crushed shoots of S. sclarea in the composition of the food. Thus, excess body weight of rats in the conditions of hypercaloric diet led to more pronounced deviations from the norm while consuming dry crushed shoots of S. officinalis. The addition of S. sclarea dry crushed shoots to the animals’ diet normalized the body weight in comparison with the control group, reduced the negative manifestations of obesity at the biochemical and organismal levels. In this regard, the substances that contains S. sclarea should be carefully studied for anti-atherosclerotic activity, and tea supplemented with S. sclarea shoots can be recommended as a corrective supplement in the diet of overweight people.

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“…Plants' anti-hyperglycemic properties are mainly related to their ability to improve the performance of pancreatic tissue, which is accomplished by elevating insulin secretions or limiting glucose absorption in the intestine [16,21,22]. The number of people living with diabetes is rising, creating concerns among medical professionals and the general population.…”

Section: Anti-diabetic Effect Of Medicinal Plantsmentioning

confidence: 99%

A Review on the Antidiabetic Potential of Medicinal Plants

Bushnak¹,

Hajj²,

Jaber³

2021

SJMH

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Diabetes mellitus has long been seen as a substantial economic burden on patients, their families, and society. Impairment in blood sugar regulation has major health repercussions. Furthermore, untreated diabetes causes major chronic complications like blindness, renal failure, and heart failure, as well as an increase in associated mortality. New anti-diabetic medicines are being researched to help alleviate this issue. Conventional Anti-diabetic medications are beneficial, several synthetic drugs are available in the market to treat diabetes, but they are costly and come with inevitable adverse effects. Medicinal plants, on the other hand, may serve as an alternate source of anti-diabetic agents. According to the World Health Organization, 80 % of the population in underdeveloped nations still relies on traditional medicines or folk medicines, which are largely made from plants, for disease prevention or treatment. For instance, anti- proliferative, anti-viral, anti-inflammatory and anti-hyperglycemic effects. In order to find a natural anti-diabetic source that comes with less side effects, several studies have been conducted. The aim of this work is to review these studies and highlight the potential of plants when it comes to their anti-diabetic effect.

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Middle East Medicinal Plants in the Treatment of Diabetes: A Review

Cited by 57 publications

References 302 publications

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Effect of Salvia officinalis and S. sclarea on rats with a high-fat hypercaloric diet

A Review on the Antidiabetic Potential of Medicinal Plants

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