Middle east tuberculosis in an immunocompromised patient: Case report and review of the literature

Velepić, Marko; Vukelić, Jelena; Dvojkovic, Zana; Škrobonja, Ivana

doi:10.1016/j.jiph.2020.10.011

Cited by 7 publications

(21 citation statements)

References 18 publications

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“…Se seleccionaron un total de 25 artículos, de los cuales 7 corresponden a series de casos [3,5,12-14,16,26] y 18 a casos ficaron un 17% de casos de tuberculosis extrapulmonar en la Región Europea de la OMS [1], siendo la afectación del oído medio una forma excepcional de la enfermedad que supone menos del 0,1% de todos los casos de tuberculosis [2].…”

Section: Resultsunclassified

“…En cuanto a la afectación, la unilateral fue más frecuente (n=33, 76,74%), aunque 10 presentaron afectación bilateral (23,25%). Respecto a la sintomatología, el síntoma predominante fue la otorrea, presente en el 100% de los casos, seguido de pérdida auditiva (n=37; 86,05%), perforación timpánica (n=19; 44,19%), parálisis facial (N=12; 27,91%) y otalgia (n=13; 30,23%) [2,3,7,8,14,16,21,22,[24][25][26][27]. Otros síntomas menos comunes fueron tinnitus y vértigos (ambos n=4; 9,30%).…”

Section: Presentación Del Casounclassified

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Tuberculous otitis media: A case presentation and review of european literature

Aguilera-Franco,

Franco-Acosta,

Yépez-Naranjo

et al. 2023

Rev Esp Quimioter

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Tuberculous otitis media (TOM) is a rare affectation in our environment that represents a challenge in its diagnosis due to the non-specific symptoms that it usually presents. This paper presents our experience in the diagnosis of a case of TOM in a 66-year-old woman with hearing loss and chronic otorrhea of more than 6 months of evolution that did not respond to conventional treatments. In addition, a review of the cases published in the last 20 years (2000-2022) in countries of the European Union (EU) is carried out. The most common symptoms were otorrhea (n=43; 100%), hearing loss (n=37; 86.05%), eardrum perforation (n=19; 44.18%), facial paralysis (n=12, 27,91%) and ear pain (n=13; 30,23%). The most used sample for diagnosis was the biopsy obtained by mastoidectomy (n=34; 79.06%). All patients were given antituberculous therapy for a mean duration of 8.11 months (range, 6-12 months). The most frequent aftereffect was hearing loss (n=28; 65.12%). TOM should be included in the differential diagnosis of chronic suppurative otitis, since early diagnosis and treatment reduce the probability of suffering irreversible sequelae.

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Section: Resultsunclassified

Section: Presentación Del Casounclassified

Tuberculous otitis media: A case presentation and review of european literature

Aguilera-Franco,

Franco-Acosta,

Yépez-Naranjo

et al. 2023

Rev Esp Quimioter

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“…Subsequent screening of the fulltext articles yielded 48 studies, including 4 obtained from reference review (Figure 1). 2,4,5,[7][8][9][10]12,13, 41 retrospective case reports and 7 retrospective case series were included in this systematic review (Table 1).…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

“…[2][3][4] Tuberculous otitis media (TOM) is a rare form of extrapulmonary TB, accounting for 0.1% of all TB cases and 0.04-0.9% of chronic suppurative otitis media (CSOM) cases. [5][6][7] The pathogenesis of TOM typically involves contiguous spread through the eustachian tube, hematogenous spread from the lungs and other distant organs, or direct implantation through the external auditory canal and tympanic membrane (TM) perforation. 8 Clinical presentation of TOM is often described as a classic triad: painless otorrhea, multiple TM perforations, and facial paralysis (FP).…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis of the middle ear: A systematic review

Pai

Omiunu

Peddu

et al. 2022

American Journal of Otolaryngology

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“…3,30 Manifestations of TB in lymph nodes have some features that may allow at least a diagnostic suspicion via radiological examinations like computed tomography, 17 which was possible in almost half of the patients who received a CT scan in the present study, yet is way to unspecific to exclude other differential diagnoses. Manifestations in middle ear, 31,32 larynx, 11,30 or intranasal mucosa, 33 however, are rarely ever suspected to be related to TB due to their unspecific characteristics. 17 In literature as well as in our analysis, lymph node TB is by far the most common head and neck manifestation.…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis in the Head and Neck: Changing Trends and Age‐Related Patterns

et al. 2021

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To evaluate changing trends in patient collectives, age-related patterns of manifestation, and diagnostic pathways of patients with extrapulmonary head and neck tuberculosis (TB), and to provide strategies to fasten diagnosis in these patients.Study design: Case control study. Methods: A 10-year retrospective analysis of 35 patients diagnosed with extrapulmonary TB in the head and neck at a tertiary university institution from 2009 to 2019, with special focus on the influence of the patient's age on consideration of TB and clinical patterns.Results: The vast majority of patients younger than 40 years had their origin in countries with high TB burden (P = .0003), and TB was considered very early as a differential diagnosis (P = .0068), while most patients older than 40 years were domestic citizens initially suspected for a malignancy, who more often had an underlying immunosuppressive condition (0.0472). Most frequent manifestations in both groups were the lymph nodes, larynx, and oropharynx. Surprisingly, no differences in the rates of open TB or history of TB infection in the family anamnesis were found. Conclusion:The two groups of patients found most often are younger patients migrating from regions with high TB burden and elderly domestic patients suffering from immunosuppressive conditions, with the latter often being misdiagnosed as malignancies. TB remains an important but difficult differential diagnosis, due to the initially unspecific symptoms and the great variety in the presentation of manifestations in the head and neck.

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Middle east tuberculosis in an immunocompromised patient: Case report and review of the literature

Cited by 7 publications

References 18 publications

Tuberculous otitis media: A case presentation and review of european literature

Tuberculous otitis media: A case presentation and review of european literature

Tuberculosis of the middle ear: A systematic review

Tuberculosis in the Head and Neck: Changing Trends and Age‐Related Patterns

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