Midlife predictors of active and healthy aging (AHA) among older businessmen

Urtamo, Annele; Huohvanainen, Emmi; Pitkälä, Kaisu H.; Strandberg, Timo

doi:10.1007/s40520-018-1100-0

Cited by 9 publications

(14 citation statements)

References 39 publications

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“…Our findings agree with most previous studies which have shown the importance of lifestyle factors on HA [2,[5][6][7]9]. In prior longitudinal observational studies, a positive association between physical activity and HA has consistently been shown [5][6][7], independently of the definition and variable operationalization. In a study in five Latin American countries [2], physically active participants were most likely to be successful agers at follow-up.…”

Section: Discussionsupporting

confidence: 93%

“…In our study, in the HR analysis, overweight and obesity increased the risk of losing HA, and no relationship was found with HA77 and HA90. This result might be explained because higher BMI in midlife has been associated with unhealthy survival [6], which in our study would lead to loss of the HA status in midlife. Therefore, many prevalent cases, which lost HA status in midlife, were excluded from the analysis and this relationship might be understated.…”

Section: Discussionmentioning

confidence: 73%

“…Attaining healthy aging (HA) has become a public health challenge, and it is fundamental to identify the variables that are associated with it. Previous studies in Europe and US have found that a combination of genetic and lifestyle factors plays a critical role in HA [2][3][4][5][6][7]. Prior studies in Caucasian populations showed that individuals with long-lived parents tend to be healthy agers [3,8], and some studies have found associations with the Apolipoprotein E (APOE) gene [8].…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with healthy aging in septuagenarian and nonagenarian Mexican adults

2020

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To examine the factors associated with healthy aging in a cohort of Mexican adults after a follow-up of 14 years. Study design: Participants were part of a prospective cohort of the Mexican Healthy Aging Study (MHAS), from which we included 5142 individuals aged 63 years or more. Main outcome: Healthy aging, defined as reaching age 77 or 90 without major chronic conditions or physical limitations. Measures: Information on age, education, marital status, smoking, alcohol consumption, physical activity, selfperceived depression, health conditions and history of age-related diseases was collected at baseline and followup. Results: Among the overall cohort, 57.8% experienced healthy survival to age 77 and 42.2% had died before age 77 or were undergoing normal aging. Participants with long-lived parents and who exercised had a lower risk of being non-healthy agers. Being overweight, obese or a smoker increased the risk of being a non-healthy ager. Physically active participants had increased odds of healthy aging at age 77 (OR: 1.17; 95% CI: 1.01-1.46) and at age 90 (OR: 1.5; 95% CI: 1.01-2.24). Depression had a negative relationship with healthy aging at age 90 (OR: 0.66; 95% CI: 0.45-0.97). Maternal longevity was associated with healthy aging only at age 77 (OR = 1.34; 95% CI: 1.04-1.72). Conclusions: Our findings support the view that a combination of genetic and behavioral factors is associated with healthy aging. In accordance with findings in Caucasian populations, our data suggest for the first time that there might also be a genetic determinant for healthy ageing in Latin Americans.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

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Factors associated with healthy aging in septuagenarian and nonagenarian Mexican adults

2020

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“…Our results also support this theory. Prevention and advanced treatment of chronic diseases enable an individual to maintain functionality and age "successfully" [23][24][25][26][27][28][29][30][31][32]. Cardiovascular risk factors are well known, and their treatments have developed during past decades [33], although intensity of treatment varies between various risk factors despite effective treatments for, e.g., hypertension and dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Major cardiovascular disease (CVD) risk factors in midlife and extreme longevity

et al. 2019

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Background The studies on the association of various midlife risk factors with reaching 90 years or more are scarce. We studied this association in a socioeconomically homogenous cohort of businessmen. Methods The study consists of men (n = 970) from the Helsinki Businessmen Study cohort (born 1919–1928). Five major cardiovascular disease (CVD) risk factors (smoking, BMI, blood pressure, serum lipids, fasting glucose), consumption of alcohol and coffee, self-rated health and self-rated fitness, were assessed in 1974, at an average age of 50 years. The number of major risk factors was tested as a risk burden. The Charlson Comorbidity Index and the RAND-36 (SF-36) Physical and Mental health summary scores were calculated from surveys in year 2000, at age of 73 years. Mortality dates were retrieved through 31 March 2018 from the Population Information System of Finland. Results 244 men survived to the age of 90 representing 25.2% of the study cohort. The survivors had less risk factor burden in midlife, and less morbidity and higher physical health summary score in 2000. Of those with five major risk factors only 7% survived up to 90 years, whereas 51% of those without any risk factors reached that age. Single risk factors reducing odds of reaching 90 years were smoking (odds ratio [OR] 0.48, 95% confidence interval [CI] 0.34–0.67), glucose (0.66, 0.49–0.88), BMI (0.63, 0.46–0.86), and cholesterol (0.71, 0.53–0.96). Conclusion Lack of five major CVD risk factors in midlife strongly increased odds of reaching 90 years of age and also predicted factors related to successful ageing in late life.

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“…Early recognition of the modifiable physiological and psychosocial risk factors that impact our lifespans is important, as it enables early interventions [ 10 , 11 ], and therefore research conducted at mid-life is especially significant. Among the well-established risk factors determining longevity recognized to date are smoking habits [ 12 , 13 ], diabetes mellitus [ 14 ], obesity [ 14 ], cardiovascular health [ 15 ], and sedentary lifestyle [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Reaching 80 Years of Age: Clinical, Behavioral, and Psychosocial Related Risk Factors in a Large Cohort of Israeli Working Men

Lev-Ari

Novak

Zemer

et al. 2021

JCM

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The objective of this study was to estimate the probability of long-term overall survival based on total number of risk factors (RF). We also sought to examine the role of midlife clinical, behavioral, and psychosocial predictors of longevity in a large cohort of Israeli men. This study was based on the Israeli Ischemic Heart Disease (IIHD) cohort that included over 10,000 men who were followed up for mortality over more than four decades. During the 43 years of follow-up, 4634 (46.1%) men survived to 80 years of age or older. We considered cigarette smoking, diabetes mellitus, high systolic blood pressure, hypercholesterolemia, low socioeconomic status, and serious family problems as RF at ages 40–65. Cox proportional hazards regression models, with age as the time scale, were constructed to estimate the hazard ratios (HRs) for failure to survive 80 years of age. Compared with men free of all the above RF, those with one identified RF (HR = 1.58, 95% CI: 1.42–1.75) and counterparts with two identified RF (HR = 2.18, 95% CI: 1.96–2.43) were at a significantly greater risk of death before 80. Additional RF further increased the risk of early mortality (HR = 3.62, 95% CI: 1.50–8.73 for men with 5 RF). The results suggest a role of physiological, behavioral, and psychological risk factors at midlife in predicting longevity.

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Midlife predictors of active and healthy aging (AHA) among older businessmen

Cited by 9 publications

References 39 publications

Factors associated with healthy aging in septuagenarian and nonagenarian Mexican adults

Factors associated with healthy aging in septuagenarian and nonagenarian Mexican adults

Major cardiovascular disease (CVD) risk factors in midlife and extreme longevity

Reaching 80 Years of Age: Clinical, Behavioral, and Psychosocial Related Risk Factors in a Large Cohort of Israeli Working Men

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