Keywords:total knee arthroplasty gait analysis range of motion kinematics Reduced peak knee flexion during stair descent (PKSD) is demonstrated in subjects with total knee arthroplasty (TKA), but the underlying factors are not well studied. 3D gait patterns during stair descent, peak passive knee flexion (PPKF), quadriceps strength, pain, proprioception, demographics, and anthropometrics were assessed in 23 unilateral TKA-subjects~19 months post-operatively, and in 23 controls. PKSD, PPKF and quadriceps strength were reduced in the TKA-side, but also in the contralateral side. A multiple regression analysis identified PPKF as the only predictor (57%) to explain the relationship with PKSD. PPKF was, however sufficient for normal PKSD. Deficits in quadriceps strength in TKA-group suggest that strength is also contributing to smaller PKSD. Increased hip adduction at PKSD may indicate both compensatory strategy and reduced hip strength.© 2013 Elsevier Inc. All rights reserved.Studies show that total knee arthroplasty (TKA) gives rise to various movement abnormalities, such as gait asymmetries including reduced knee flexion [1]. Functional performance following knee arthroplasty may be assessed in stair gait [2]. Descending stairs requires more knee flexion than ascending stairs [3], and there is evidence of reduced knee flexion in stair descent after TKA [4,5]. Although it is concluded that flexion in the prosthetic knee is reduced during stair descent [2,[4][5][6], the underlying mechanisms are uncertain. Although knee flexion is restricted due to the mechanics of the prosthesis [7], stair studies show that the range of motion (ROM) leaves a margin of 6°-16°, theoretically permitting sufficient knee flexion for normal stair descent [4][5][6]. There are, however also other qualities with TKA that may be important to consider, such as reduced or increased sagittal laxity in the prosthetic knee joint [8][9][10]. In posterior cruciate retaining knee prostheses a paradoxical forward slide instead of a normal rollback of the tibio-femoral contact point occurs with increasing flexion. This suggests that TKA related factors other than reduced ROM, may be responsible for reduced knee flexion in stair descent [7]. Also factors outside joint mechanics may be considered, such as weakness of the knee and hip muscles [11][12][13][14] Studies on level walking propose that asymmetrical gait after TKAsurgery is retained from the pre-surgery gait and characterized by a specific walking pattern, presumably for unloading the affected knee [1]. Asymmetrical gait patterns are shown to be retained up to 18 months after surgery in spite of little or no pain [21]. Similarly, subjects with osteoarthritis have demonstrated decreased knee flexion during stair descent compared to knee-healthy subjects [25]. Asymmetrical gait patterns after a TKA may predispose the individual to contralateral joint degeneration [1], and the risk of the contralateral knee to progress to TKA due to osteoarthritis has been estimated to be 37.2% within 10 years [26...