Mielopatía por déficit de vitamina B12: caracterización clínica de 11 casos

Nogales-Gaete, Jorge; P, Paula Jiménez; F, Pía García; M, David Sáez; C, Rodrigo Aracena; González, Javier; R, Luis Lay-Son; F, Eugenio Tenhamm; R, Tatiana Figueroa; M, Andrea Chávez; B, Carolina Oelker; M, Luis Vega

doi:10.4067/s0034-98872004001100006

Cited by 7 publications

(2 citation statements)

References 16 publications

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“…This may be preceded and accompanied by sensory nerve abnormalities, and cranial (including optic) nerve and cerebellar abnormalities may also occur (Ahn et al, 2004). Presenting symptoms consist of paresthesias, with the later appearance of sphincter dysfunction, posterior column (abnormal proprioception) and pyramidal (motor weakness/spasticity) syndromes (Nogales-Gaete et al, 2004). The peripheral neuropathy associated with cobalamin deficiency is an axonopathy, and autonomic neuropathy in the form of postural hypotension may also occur (Kayser-Gatchalian and Neundörfer, 1977; McCombe and Mcleod, 1984).…”

Section: 0 Vitamin Deficiency Chemicals and Neurological Diseasementioning

confidence: 99%

Interrelationships of undernutrition and neurotoxicity: Food for thought and research attention

Spencer

Palmer

2012

NeuroToxicology

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Section: 0 Vitamin Deficiency Chemicals and Neurological Diseasementioning

confidence: 99%

Interrelationships of undernutrition and neurotoxicity: Food for thought and research attention

Spencer

Palmer

2012

NeuroToxicology

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“…La alteración de dichos procesos en el SNC puede causar enfermedades neurológicas o psiquiátricas, tales como neuropatía periférica, depresión, edeterioro cognitivo y demencia [6][7][8] . Es importante destacar que estos síntomas pueden manifestarse en ausencia de alteraciones hematológicas en 20-30% de los sujetos.…”

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Déficit de vitamina B-12 en adultos mayores: ¿Un problema de salud pública en Chile?

Sánchez

Albala

et al. 2010

Rev. méd. Chile

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Prevalence of vitamin B-12 deficiency in older adults Background: There is a correlation between aging and the decrease of plasma levels of vitamin B-12. Aim: To determine the prevalence of vitamin B-12 and folate deficiency and its hematological impact among older adults (AM). Material and Methods: Cross-sectional study, in 1028 subjects aged 65 to 87 years, living in community and evaluated between 2005 and 2008. Percentile distribution of vitamin B-12, folate, hemoglobin, packed red cell volume and mean cell volume by gender and age were analyzed. Deficiency was defined as vitamin B-12 levels < 148 pmol/L, marginal deficiency as vitamin B-12 levels < 221 pmol/L, anemia was defined as an hemoglobin < 13 and 12 g/dL among men and women, respectively. Results: The prevalence of vitamin B-12 deficiency was 12% and the figure for marginal deficiency was 25.4%. Males were more affected than females (p < 0.001). The frequency of anemia was 8.6%, and was higher among women (p = 0.004). Conclusions: There is a high prevalence of full blown and marginal deficit of vitamin B-12 among the elderly. This deficiency should be considered for correction through public nutrition policies.

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The neurology of folic acid deficiency

2014

Handbook of Clinical Neurology

127

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Mielopatía por déficit de vitamina B12: caracterización clínica de 11 casos

Abstract: Subacute combined degeneration must be suspected in patients older than 60 years with a subacute myelopathic syndrome and low serum vitamin B12 levels.

Cited by 7 publications

References 16 publications

Interrelationships of undernutrition and neurotoxicity: Food for thought and research attention

Interrelationships of undernutrition and neurotoxicity: Food for thought and research attention

Déficit de vitamina B-12 en adultos mayores: ¿Un problema de salud pública en Chile?

The neurology of folic acid deficiency

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