MIF/CD74 axis participates in inflammatory activation of Schwann cells following sciatic nerve injury

Song, Honghua; Zhu, Ziwen; Zhou, Yue; Du, Nan; Song, Tiancheng; Liang, Hao; Chen, Xiaojun; Wang, Yingjie; Wang, Yongjun; Hu, Yuming

doi:10.1007/s10735-019-09832-0

Cited by 17 publications

(13 citation statements)

References 53 publications

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“…Also, in vitro studies show that MIF facilitates Schwann cell migration. Both Schwann cell proliferation and migration promote nerve regeneration (104). A separate in vitro study demonstrated that CD74 activation by MIF promoted cell survival and proliferation of neural progenitor cells (105).…”

Section: Cd74 Activity In Other Organs and Tissuesmentioning

confidence: 99%

Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair

2020

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Wound healing after an injury is essential for life. An in-depth understanding of the healing process is necessary to ultimately improve the currently limited treatment options for patients suffering as a result of damage to various organs and tissues. Injuries, even the most minor, trigger an inflammatory response that protects the host and activates repair pathways. In recent years, substantial progress has been made in delineating the mechanisms by which inflammatory cytokines and their receptors facilitate tissue repair and regeneration. This mini review focuses on emerging literature on the role of the cytokine macrophage migration inhibitory factor (MIF) and its cell membrane receptor CD74, in protecting against injury and promoting healing in different parts of the body.

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Section: Cd74 Activity In Other Organs and Tissuesmentioning

confidence: 99%

Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair

2020

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“…The PNS has the potential to extensively regenerate after damage in a process supported by dedifferentiated Schwann cells (63,64). Recent work has uncovered multiple mechanisms that control Schwann cell reprogramming and subsequent nerve regeneration (65)(66)(67). Together, these findings suggest that nerve regeneration, in addition to immune destruction, could also play an important role in CIDP disease outcome.…”

Section: Nerve-resident Cells In Inflammationmentioning

confidence: 99%

Deciphering immune mechanisms in chronic inflammatory demyelinating polyneuropathies

Wolbert¹,

Cheng²,

Hörste³

et al. 2020

JCI Insight

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“…These indicated that these 10 core genes were significantly associated with SNI at both adult and neonate ages. More and more studies on transcriptomic analysis in vitro and in vivo verify that Cd74 played a vital part in the progression of sciatic nerve injury [ 41 – 44 ]. Linnartz-Gerlach et al [ 45 ] reported that Tyrobp mutations or genetic variants were associated with the aging-related inflammatory neurodegenerative disorders.…”

Section: Discussionmentioning

confidence: 99%

Gene correlation network analysis to identify regulatory factors in sciatic nerve injury

Ling

et al. 2021

J Orthop Surg Res

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Background Sciatic nerve injury (SNI), which frequently occurs under the traumatic hip and hip fracture dislocation, induces serious complications such as motor and sensory loss, muscle atrophy, or even disabling. The present work aimed to determine the regulating factors and gene network related to the SNI pathology. Methods Sciatic nerve injury dataset GSE18803 with 24 samples was divided into adult group and neonate group. Weighted gene co-expression network analysis (WGCNA) was carried out to identify modules associated with SNI in the two groups. Moreover, differentially expressed genes (DEGs) were determined from every group, separately. Subsequently, co-expression network and protein–protein interaction (PPI) network were overlapped to identify hub genes, while functional enrichment and Reactome analysis were used for a comprehensive analysis of potential pathways. GSE30165 was used as the test set for investigating the hub gene involvement within SNI. Gene set enrichment analysis (GSEA) was performed separately using difference between samples and gene expression level as phenotype label to further prove SNI-related signaling pathways. In addition, immune infiltration analysis was accomplished by CIBERSORT. Finally, Drug–Gene Interaction database (DGIdb) was employed for predicting the possible therapeutic agents. Results 14 SNI status modules and 97 DEGs were identified in adult group, while 15 modules and 21 DEGs in neonate group. A total of 12 hub genes was overlapping from co-expression and PPI network. After the results from both test and training sets were overlapped, we verified that the ten real hub genes showed remarkably up-regulation within SNI. According to functional enrichment of hub genes, the above genes participated in the immune effector process, inflammatory responses, the antigen processing and presentation, and the phagocytosis. GSEA also supported that gene sets with the highest significance were mostly related to the cytokine–cytokine receptor interaction. Analysis of hub genes possible related signaling pathways using gene expression level as phenotype label revealed an enrichment involved in Lysosome, Chemokine signaling pathway, and Neurotrophin signaling pathway. Immune infiltration analysis showed that Macrophages M2 and Regulatory T cells may participate in the development of SNI. At last, 25 drugs were screened from DGIdb to improve SNI treatment. Conclusions The gene expression network is determined in the present work based on the related regulating factors within SNI, which sheds more light on SNI pathology and offers the possible biomarkers and therapeutic targets in subsequent research.

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MIF/CD74 axis participates in inflammatory activation of Schwann cells following sciatic nerve injury

Cited by 17 publications

References 53 publications

Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair

Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair

Deciphering immune mechanisms in chronic inflammatory demyelinating polyneuropathies

Gene correlation network analysis to identify regulatory factors in sciatic nerve injury

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