Mifepristone and Misoprostol Administered Simultaneously Versus 24 Hours Apart for Abortion

Creinin, Mitchell D.; Schreiber, Courtney A.; Bednarek, Paula H.; Lintu, H.; Wagner, Marie Soleil; Meyn, Leslie A.

doi:10.1097/01.aog.0000258298.35143.d2

Cited by 97 publications

(76 citation statements)

References 31 publications

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“…With a regimen of mifepristone and vaginal misoprostol, approximately 3% to 5% of women will subsequently undergo uterine evacuation [1][2][3]. Regimens using mifepristone and buccal misoprostol have a similar (3.3%) risk of requiring uterine evacuation [4,5].…”

Section: Introductionmentioning

confidence: 99%

Predictors of uterine evacuation following early medical abortion with mifepristone and misoprostol

2016

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Section: Introductionmentioning

confidence: 99%

Predictors of uterine evacuation following early medical abortion with mifepristone and misoprostol

2016

Self Cite

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“…Also, the data collected on 16 000 women who had been treated with 600 mg of mifepristone followed by a prostaglandin analogue 24-72 hours later suggested that the efficacy was highest if the interval was 48 hours. 9 Different time intervals between mifepristone and misoprostol have also been tested 10 or both drugs have been administered simultaneously, 11 repeating the dose of misoprostol if abortion was not complete. When misoprostol was not repeated, complete abortion rates seem to be significantly lower with shorter intervals.…”

Section: Introductionmentioning

confidence: 99%

Two mifepristone doses and two intervals of misoprostol administration for termination of early pregnancy: a randomised factorial controlled equivalence trial*

Hertzen¹,

Piaggio²,

Wojdyla³

et al. 2009

BJOG

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Objective To compare the efficacy of 100 mg and 200 mg of mifepristone and 24-and 48-hour intervals to administration of 800mg vaginal misoprostol for termination of early pregnancy.Design Placebo-controlled, randomized, equivalence trial, stratified by centre.Setting 13 departments of obstetrics and gynecology in nine countries.Population 2181 women with 63 days or less gestation requesting medical abortion.Methods Two-sided 95% CI for the risk differences of failure to complete abortion were calculated and compared with 5% equivalence margin between two doses of mifepristone and two intervals to misoprostol administration. Proportions of women with adverse effects were compared between the regimens using standard testes for proportions.Outcome measures Rates of complete abortion without surgical intervention and adverse effects associated with the regimens.Results Efficacy outcome was analysed for 2126 women (97.5%) excluding 55 lost to follow up. Both mifepristone doses were found to be similar in efficacy. The rate of complete abortion was 92.0% for women assigned 100 mg of mifepristone and 93.2% for women assigned 200 mg of mifepristone (difference 1.2%, 95% CI: -1.0 to 3.5). Equivalence was also evident for the two intervals of administration: the rate of complete abortion was 93.5% for 24-hour interval and 91.7% for the 48-hour interval (difference -1.8%, 95% CI: -4.0 to 0.5). Interaction between doses and interval to misoprostol administration was not significant (P = 0.92). Adverse effects related to treatments did not differ between the groups.Conclusions Both the 100 and 200 mg doses of mifepristone and the 24-and 48-hour intervals have a similar efficacy to achieve complete abortion in early pregnancy when mifepristone is followed by 800 micrograms of vaginally administered misoprostol.

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“…similar success rate has been shown by studies conducted by Crenin et al (94%). 11 Scaff et al, the advantage of medical abortion is that it has high efficacy at gestational age ≤49 days. 13 This study emphasizes on proper selection of patients by using various inclusion and exclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

Medical methods of abortion using lowest effective dose of mifepristone and misoprostol: case study of 100 women

Anjum

Nivedita

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Medical abortion or Medical Methods of abortion (MMA) (or Chemical abortion) is defined as “the non-surgical way of termination of termination of pregnancy by a drug or combination of drugs”. With introduction of MMA there has been a steep rise in abortion related complications due to irrational use of these drugs. This study is undertaken using lowest effective dose of mifepristone and misoprostol in 100 women willing for termination of pregnancy with period of gestation <49 days to study the efficacy, side effects and failure rate. Present study emphasizes on using MMA by proper selection of patient, adhering to proper schedule under provision of MTP Act (counselling, consent, examination, confirmation of pregnancy, prescription by a registered medical practioner) in order to enhance efficacy and avoid complications.Methods: Prospective Clinical Study consist of use of single dose of 200mg of mifepristone orally followed by misoprostol (400µg) by vaginal route for terminating pregnancy in ≤49 days of gestation. Statistical analysis done by Chi square test.Results: In this study, success rate i.e. complete abortion without requiring surgical procedure was 96%and failure rate was 4%. Nausea (56%) is the most common side effect of Mifepristone. Chills (33%) is the most common side effect of Misoprostol. Mean Induction Abortion Interval is 2.17±1.2 hrs. Mean Duration of Bleeding is 7.79±4.42 days.Conclusions: Medical abortion is a promising method of early abortion in a developing country like India as it requires no technical skills and manpower with a good safety profile.

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Mifepristone and Misoprostol Administered Simultaneously Versus 24 Hours Apart for Abortion

Abstract: I.

Cited by 97 publications

References 31 publications

Predictors of uterine evacuation following early medical abortion with mifepristone and misoprostol

Predictors of uterine evacuation following early medical abortion with mifepristone and misoprostol

Two mifepristone doses and two intervals of misoprostol administration for termination of early pregnancy: a randomised factorial controlled equivalence trial*

Medical methods of abortion using lowest effective dose of mifepristone and misoprostol: case study of 100 women

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