Migraine and associated comorbidities are three times more frequent in children with ADHD and their mothers

Kütük, Meryem Özlem; Tufan, Ali Evren; Güler, Gülen; Yalın, Osman Özgür; Altıntaş, Ebru; Bag, Harika Gozukara; Uludüz, Derya; Toros, Fevziye; Aytan, Nurgül; Kütük, Özgür; Özge, Aynur

doi:10.1016/j.braindev.2018.06.001

Cited by 33 publications

(40 citation statements)

References 37 publications

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“…However, this did not translate into an association with clinically diagnosed ADHD that was statistically significant. Previous studies have pointed to an association between these two disorders using various study instruments [24][25][26][27]. This association is also been reported across child and adolescent [24][25][26] as well as adult populations [27].…”

Section: Discussionmentioning

confidence: 62%

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Migraine, attention deficit hyperactivity disorder and screen time in children attending a Sri Lankan tertiary care facility: are they associated?

2020

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Background: Headache and Attention Deficit Hyperactivity Disorder (ADHD) are two relatively common, neuropsychiatric conditions seen in children. Recent studies have shown an association between these two disorders, which are otherwise distinct conditions. This study aims to assess the association between migraine and ADHD, as well as the association between screen-time and these two conditions, among children attending a Sri Lankan tertiary care facility. Possible associations will have important implications in the clinical management of these conditions. Methods: This was a comparative cross-sectional study of 226 children aged 5-14 years, attending clinics at a tertiary care hospital in Galle, Sri Lanka. Of them, 141 had a diagnosis of migraine and 85 did not have migraine. The presence or absence of ADHD and the use of screen-time among the two groups was analysed. Chi-square test and Mann-Whitney U test was used to assess the associations between these variables. Results: Approximately 5% of the children with migraine had clinically diagnosed ADHD, compared to 3.5% of those without migraine (p = 0.862). The median SNAP-IV scores (inter-quartile range) of the children with migraine and without migraine were 0.60 (0.27-1.00) and 0.44 (0.16-0.80) respectively (p = 0.014). There was no significant difference in screen-time hours per day between children with and without clinically diagnosed ADHD. However, a significant difference in median screen-time (hours per day) was observed between children with and without migraine (2.0 h and 1.0 h respectively; p = 0.012). Conclusions: Our findings suggest that children with migraine are more likely to show features of hyperactivity/ impulsivity and inattentiveness than those without migraine. While no association was found between clinically diagnosed ADHD and screen-time, migraine was associated with longer daily screen use. Screening for ADHD in children diagnosed with migraine may be of benefit. Further studies are required to understand the possible benefits of reducing screen-time in children with migraine.

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Section: Discussionmentioning

confidence: 62%

“…Several recent studies have indicated a positive relationship between ADHD and migraine, in both children and adults [13,[24][25][26][27][28][29]. A recent meta-analysis reported a positive association between these two conditions [24].…”

Section: Introductionmentioning

confidence: 99%

Migraine, attention deficit hyperactivity disorder and screen time in children attending a Sri Lankan tertiary care facility: are they associated?

2020

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“…A recent review on somatic comorbidity among adults with ADHD found that asthma is a well-documented comorbidity among adults with ADHD while the number of studies looking at the associations between ADHD and epilepsy, migraine, GI disorders and enuresis are still very few, ranging from one to three studies each (Instanes et al 2018 ). A recent familial association case-control study of 117 children and adolescents with DSM-5 ADHD reported that a headache disorder diagnosis was common for both patients and healthy controls (59.0% vs. 37.8%), and migraine was found in 26.0% of ADHD cases and 9.9% of healthy controls (Kutuk et al 2018 ). A positive association between the prescription of anti-migraine and ADHD medications and higher prevalence of migraine was found among adults with ADHD in Norway (Fasmer et al 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Physical health in children with neurodevelopmental disorders

Alabaf

Gillberg

Lundström

et al. 2018

J Autism Dev Disord

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With increasing numbers of children being diagnosed with neurodevelopmental disorders (NDDs) attention has been drawn to these children's physical health. We aimed to identify the prevalence of defined physical problems (epilepsy, migraine, asthma, cancer, diabetes, psoriasis, lactose intolerance, celiac disease, diarrhea, constipation, daytime enuresis, encopresis) in a nationwide population of 9-and 12-year-old twins subdivided into those with and without indications of NDDs. Parents of 28,058 twins participated in a well-validated telephone interview regarding their children's mental health and answered questions about their physical problems. The results indicate a high rate of physical problems in children with NDDs, particularly in those with indications of the presence of combinations of several NDDs.

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“…Enuresis occurs in approximately 17% of children with ADHD, 60 and sleep disorders in 25 to 70%. 61 Frequent neurological comorbidities of ADHD include migraine (about thrice more frequent in ADHD than in typically developing [TD] children) 62 63 64 and epilepsy (2.3 to thrice more frequent in ADHD than in TD children). 65 66 The risk of coexisting ADHD being seen as a comorbid condition and not the primary diagnosis is considerably enhanced in many childhood disorders of different origins.…”

Section: Comorbidity Differential Diagnosis and Clinical Assessmentmentioning

confidence: 99%

ADHD: Current Concepts and Treatments in Children and Adolescents

et al. 2020

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Attention deficit hyperactivity disorder (ADHD) is among the most frequent disorders within child and adolescent psychiatry, with a prevalence of over 5%. Nosological systems, such as the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and the International Classification of Diseases, editions 10 and 11 (ICD-10/11) continue to define ADHD according to behavioral criteria, based on observation and on informant reports. Despite an overwhelming body of research on ADHD over the last 10 to 20 years, valid neurobiological markers or other objective criteria that may lead to unequivocal diagnostic classification are still lacking. On the contrary, the concept of ADHD seems to have become broader and more heterogeneous. Thus, the diagnosis and treatment of ADHD are still challenging for clinicians, necessitating increased reliance on their expertise and experience. The first part of this review presents an overview of the current definitions of the disorder (DSM-5, ICD-10/11). Furthermore, it discusses more controversial aspects of the construct of ADHD, including the dimensional versus categorical approach, alternative ADHD constructs, and aspects pertaining to epidemiology and prevalence. The second part focuses on comorbidities, on the difficulty of distinguishing between “primary” and “secondary” ADHD for purposes of differential diagnosis, and on clinical diagnostic procedures. In the third and most prominent part, an overview of current neurobiological concepts of ADHD is given, including neuropsychological and neurophysiological researches and summaries of current neuroimaging and genetic studies. Finally, treatment options are reviewed, including a discussion of multimodal, pharmacological, and nonpharmacological interventions and their evidence base.

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Migraine and associated comorbidities are three times more frequent in children with ADHD and their mothers

Cited by 33 publications

References 37 publications

Migraine, attention deficit hyperactivity disorder and screen time in children attending a Sri Lankan tertiary care facility: are they associated?

Migraine, attention deficit hyperactivity disorder and screen time in children attending a Sri Lankan tertiary care facility: are they associated?

Physical health in children with neurodevelopmental disorders

ADHD: Current Concepts and Treatments in Children and Adolescents

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