Migraine and structural changes in the brain

Bashir, Asma; Lipton, Richard B.; Ashina, Sait; Ashina, Messoud

doi:10.1212/wnl.0b013e3182a6cb32

Cited by 284 publications

(277 citation statements)

References 53 publications

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“…The pathological findings of these lesions have been attributed to microvascular damage. 2 In our study, WML was detected in 40% of the patients; the RNFL thicknesses of these patients were compared with those of migraine patients without WML and the control group. These results imply that cerebral WML may be related to the reduction in RNFL thickness in migraine patients.…”

Section: Discussionmentioning

confidence: 86%

“…Migraine affects up to 16% of the general population. [1][2][3] There are several hypotheses about the pathogenesis of migraine: inherited alteration of brain excitability, intracranial arterial dilatation, recurrent activation and sensitisation of trigeminovascular pathway, and consequential structural and functional changes in genetically susceptible individuals. [3][4][5] As disturbances in the neurovascular system remain one of the mechanisms, the relationship between migraine and vascular events has been studied for many years.…”

Section: Introductionmentioning

confidence: 99%

“…3,6 According to the literature, a high signal on T2-weighted magnetic resonance imaging (MRI) studies on migraine patients indicates an increase in subcortical white matter lesions (WML) due to chronic ischaemia. 2,[7][8][9][10][11][12][13][14] Also, there are studies supporting the ischaemic theory by focusing on the retinal nerve fibre layer (RNFL) thickness detected by optical coherence tomography (OCT) on migraine patients and studies demonstrating that the retina and cerebral structure of migraine patients are affected. [15][16][17][18][19][20][21] In the present study, we used OCT to determine whether RNFL thickness is related to the presence of cerebral WML in migraine patients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Retinal Nerve Fibre Layer Thickness of Migraine Patients with or without White Matter Lesions

Şimşek

2016

Neuro-Ophthalmology

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The aim of this study was to determine whether retinal nerve fibre layer (RNFL) thickness is correlated with cerebral white matter lesions (WML) in migraine patients. Forty migraine and 40 healthy subjects were included in this study. The difference in RNFL thickness between the control and a migraine group with WML and a migraine group without WML were investigated using analysis of variance (ANOVA). A Tukey post hoc test was conducted to determine from which group the difference originated. Lower RNFL thicknesses were observed in the migraine patient group where WML was detected using magnetic resonance imaging (MRI), compared with the control group and with the migraine group with no WML. Statistically significant difference was found between the three groups in terms of RNFL thickness. Although there was a statistically significant difference between the control and the migraine group with WML detected with MRI, no statistically significant difference was found in terms of RNFL thickness between the control and the migraine group with no WML related to Tukey post hoc test. Moreover, there was a statistically significant difference between migraine patients with WML and patients without WML in terms of retinal nerve fibre layer thickness. The results indicate that reduction in RNFL detected via optical coherence tomography may be related to cerebral WML in migraine patients. Further studies by neurologists and ophthalmologists are necessary to determine the clinical relevance of the relation between RNFL and cerebral WML. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Retinal Nerve Fibre Layer Thickness of Migraine Patients with or without White Matter Lesions

Şimşek

2016

Neuro-Ophthalmology

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“…2012; Bashir et al. 2013). In 67% of VV patients in this study, the WMA were attributable to a vascular cause, while in three controls no underlying cause was identified.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance brain imaging in patients with visual vertigo

et al. 2015

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IntroductionPatients with visual vertigo (VV) report dizziness provoked by moving visual surroundings. It has been suggested that these subjects develop a compensation strategy for a vestibulo‐proprioceptive deficit and rely excessively on visual input. We have postulated that patients with VV might have brain abnormalities that interfere with appropriate processing of visual stimulation and performed a brain MRI study to verify this hypothesis.Materials and MethodsPatients with VV of more than 3 months duration were included. They were asked to complete the Situational Characteristic Questionnaire (SCQ) that scores for the symptoms of VV. Dizzy patients without VV served as controls. A brain MRI was performed with a Siemens 1.5 Tesla scanner in patients and controls.ResultsTwenty‐four patients with VV were included. Their mean SCQ score was 1.45 ± 0.9 (normal 0.16 ± 0.28). In 50% of patients, abnormalities in MRI imaging were found. Thirty‐three percent of 27 controls demonstrated an abnormal brain MRI. The two groups were similar in respect to the prevalence of a localized hemispheric or posterior fossa lesion (P = 0.13), but VV patients had more unspecific white matter brain changes than controls (P = 0.009). Patients and controls did not differ in age and gender distribution (P = 0.9) or the history of a neurotological event preceding their symptoms (P = 0.3).ConclusionsOur study suggests that multiple white matter lesions might contribute to occurrence of the phenomenon of VV. Future prospective large‐scale studies by specific MR techniques are indicated to validate our preliminary findings and elucidate the pathological mechanism of VV.

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“…Asymptomatic white matter abnormalities and infarct-like lesions as well as volume 9 loss of various gray/white matter structures are more common in migraineurs, particularly those with aura, than in healthy controls [20,21]. However, these structural changes are non-specific and are considered to be a consequence of repetitive migraine attacks.…”

Section: Discussionmentioning

confidence: 99%