Migraine and subclinical atherosclerosis: endothelial dysfunction biomarkers and carotid intima-media thickness: a case-control study

Avci, Aynur Yilmaz; Akkucuk, Mehmet Husamettin; Torun, Ebru; Arikan, Serap; Can, Ufuk; Tekindal, Mustafa Agâh

doi:10.1007/s10072-019-3710-5

Cited by 28 publications

(21 citation statements)

References 38 publications

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“…Among the included papers, 22 articles compared serum homocysteine levels in migraine patients and HC, 53‐74 13 articles compared serum cobalamin levels in migraine patients and HC, 56,57,63,65,66,68‐70,73,75‐78 and 13 articles compared serum folate levels in migraine patients and HC 56,57,63‐66,68‐70,73,77‐79 (Table 1). Moreover, 13 studies compared serum homocysteine levels in MA and MO patients, 54,55,57,59‐61,64,67,68,73,74,80,81 4 studies compared serum cobalamin levels in MA and MO patients, 57,68,73,77 and 5 studies compared serum folate levels in MA and MO patients 57,64,68,73,77 (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…No study evaluating serum pyridoxine was retrieved. Regarding age distribution, 19 studies involved adults, 53,55‐57,59‐61,63,64,66,68,70‐72,75,77‐80 3 studies involved children (<18 years), 54,65,76 2 studies involved both adults and non‐adult participants older than 14 62 and 15 years 58 (they were conventionally analyzed along with the adult population), and 5 studies did not present any age information 67,69,73,74,81…”

Section: Resultsmentioning

confidence: 99%

“…Bottini et al was the sole article that reported the recruitment of children and did not determine any difference in Hcy levels [SMD = 0.37, 95%CI = (−0.05, 0.79)] between children with migraine (n = 45) and HC (n = 45) 65 . There were 3 conference abstracts that did not specify the age groups, 69,73,74 while the rest 12 studies enrolled adult patients 53,55‐58,60‐63,68,70 . Hcy levels were recorder higher in adult migraine patients (n = 1074) compared to HC (n = 887) [ P Q < .1, I 2 = 76%, RE‐SMD = 0.35, 95%CI = (0.15, 0.54)].…”

Section: Resultsmentioning

confidence: 99%

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Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis

et al. 2020

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Background Migraine, especially migraine with aura (MA), has been linked to increased risk for ischemic cerebrovascular disease. The possible role of elevated serum homocysteine (Hcy, a cause of thrombophilia) in migraine has been demonstrated by several studies. Objective The present study aims to review and meta‐analyze data from studies investigating the difference of serum Hcy and Hcy lowering vitamins between migraine patients and healthy controls (HC), as well as between patients with MA and migraine without aura (MO). Methods Literature search involved MEDLINE, Embase, CENTRAL, Google Scholar, and trial registries. The Newcastle‐Ottawa Scale was used to evaluate the quality of the retrieved studies. Standardized mean differences (SMDs) and 95% confidence intervals (95%CIs) were calculated. Funnel‐plots were utilized for the evaluation of publication bias. Results Overall, 29 (28 case‐control and 1 cross‐sectional) studies were retrieved. Meta‐analysis was indicative of higher Hcy concentration in migraine patients vs HC overall [adults and children: 16 studies, I2 = 81%, SMD = 0.41, 95%CI = (0.20, 0.61)]. Hcy was consistently elevated in adults with migraine [adults: 12 studies, I2 = 76%, SMD = 0.35, 95%CI = (0.15, 0.54); children: 1 study, SMD = 0.37, 95%CI = (−0.05, 0.79)]. Subgroup analyses reproduced the results for both adults with MA [7 studies, I2 = 83%, SMD = 0.37, 95%CI = (0.03, 0.71)] and MO [5 studies, I2 = 84%, SMD = 0.46, 95%CI = (0.03, 0.89)]. Figures for serum folate were lower in the overall comparison of migraine patients with HC [adults and children: 11 studies, I2 = 87%, SMD = −0.36, 95%CI = (−0.68, −0.05); adults: 8 studies, I2 = 6%, SMD = −0.11, 95%CI = (−0.22, 0.01); children: 1 study, SMD = −0.71, 95%CI = (−1.14, −0.29); MA adults: 4 studies, I2 = 44%, SMD = −0.16, 95%CI = (−0.35, 0.04); MO adults: 4 studies, I2 = 47%, SMD = −0.17, 95%CI = (−0.44, 0.10)]. Serum vitamin B12 levels were not different between migraine patients and HC [adults and children: 11 studies, I2 = 88%, SMD = −0.24, 95%CI = (−0.57, 0.09); adults: 8 studies, I2 = 57%, SMD = −0.10, 95%CI = (−0.28, 0.08); children: 1 study, SMD = 0.29, 95%CI = (−0.13, 0.71); MA adults: 4 studies, I2 = 63%, SMD = −0.14, 95%CI = (−0.48, 0.20); MO adults: 4 studies, I2 = 59%, SMD = −0.15, 95%CI = (−0.45, 0.15)]. Serum Hcy was lower in MO than MA [adults and children: 10 studies, I2 = 39%, SMD = 0.30, 95%CI = (0.14, 0.46), adults: 6 studies, I2 = 29%, SMD = 0.21, 95%CI = (0.09, 0.36), children: 1 study, SMD = 0.51, 95%CI = (0.22, 0.80)]. Serum folate and vitamin B12 did not differ between MA and MO. Conclusions Our results suggest that there is a possible link between migraine, mainly MA, and elevated serum Hcy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis

et al. 2020

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“…In migraineurs with subclinical infarction in the CAMERA study, the clinical and radiological features of the multiple, small lesions found predominantly in the deep arterial border zone of the cerebellum suggested hypoperfusion or embolism rather than atherosclerosis 38 . In contrast, there are 7 studies reporting evidence of subclinical atherosclerosis in adults with migraine, 136‐142 including in those with episodic migraine and those with aura 136‐139 . One recent study also reported an independent association of carotid wall thickening with triptan and ergotamine consumption, suggesting that repeated use of these vasoconstrictive agents may have lasting effects 137 .…”

Section: Potential Mechanisms Of Migraine‐related Strokementioning

confidence: 99%

“…In contrast, there are 7 studies reporting evidence of subclinical atherosclerosis in adults with migraine, 136‐142 including in those with episodic migraine and those with aura 136‐139 . One recent study also reported an independent association of carotid wall thickening with triptan and ergotamine consumption, suggesting that repeated use of these vasoconstrictive agents may have lasting effects 137 . A 2019 meta‐analysis of ultrasonic assessment of CIMT in participants from 7 studies reported significantly greater CIMT in patients with migraine compared to controls, but no differences in CIMT between patients with MWA and controls, or MWoA and controls 140 .…”

Section: Potential Mechanisms Of Migraine‐related Strokementioning

confidence: 99%

Migraine and Ischemic Stroke in Women. A Narrative Review

Tietjen

Maly

2020

Headache

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Objective/Background.-Migraine is associated with ischemic stroke. Women are 3-fold as likely as men to have migraine, and high estrogen states increase the risk of migraine with aura (MWA), venous thromboembolism (VTE), and of stroke. We review the epidemiological and mechanistic evidence of the migraine-stroke relationship and its risk factors, with a focus on women and conditions that exclusively or predominantly affect them.Methods.-We performed a search of MEDLINE/PubMed database, then a narrative review of the epidemiological evidence of the migraine-stroke relationship as well as the evidence for arterial, thrombophilic, and cardiac mechanisms to explain this connection. We examine the implications of this evidence for the diagnostic evaluation and treatment of MWA.Results.-MWA is associated with multiple stroke risk factors, such as hypertension, hyperlipidemia, diabetes mellitus, cigarette smoking, atrial fibrillation, and patent foramen ovale. In women, MWA is also associated with biomarkers of endothelial activation, hormonal contraceptive use, pregnancy, and VTE. This suggests that a subset of auras may be secondary, that is, induced by ischemia related to microemboli or in situ thrombosis. MWA-associated ischemic stroke is more common in young (<45 years old) women with high frequency of migraine attacks, hormonal contraception use, and with pregnancy and preeclampsia. There is increasing evidence that cardioembolism, often in conjunction with thrombophilia, plays a prominent role in MWA-associated cerebral infarction.Conclusion.-The commonality of factors associated with MWA and with MWA-associated stroke suggest that persons with secondary, ischemia-induced aura may be at elevated risk of stroke. Although further research is needed, we recommend consideration of a diagnostic evaluation of MWA that mirrors the evaluation of transient ischemic attack, given that prophylactic treatment targeting the ischemic origin of secondary aura may prevent migraine as well as stroke.

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Evaluation of tissue and serum lipocalin 2 in psoriasis vulgaris and its implications on subclinical atherosclerosis

Hassab-El-Naby

Helal

Abdou

et al. 2021

Dermatological Reviews

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Lipocalin‐2 (LCN2) has been identified as an adipokine but its role in psoriasis has not been fully elucidated. The study aimed to evaluate serum and tissue levels of LCN2 in patients with plaque‐type psoriasis and its correlation with C‐reactive protein (CRP), disease duration, severity, and subclinical atherosclerosis. Thirty patients with psoriasis and another 15 healthy age and sex matching controls were included and LCN2 was assessed in serum and tissue from patients and controls. Total lipid profile and high‐sensitivity CRP were also measured. Carotid artery intima media thickness was determined by using high‐resolution mode ultrasound in both patients and controls. Results showed statistically higher serum and tissue levels of LCN2 in patients than controls (p = .009 and p = .025, respectively). A significant difference in the right and left IMT was noted between patients and controls (p = .02 and p = .04). In conclusion, patients with psoriasis are found to be at increased risk of atherosclerosis.

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Migraine and subclinical atherosclerosis: endothelial dysfunction biomarkers and carotid intima-media thickness: a case-control study

Cited by 28 publications

References 38 publications

Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis

Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis

Migraine and Ischemic Stroke in Women. A Narrative Review

Evaluation of tissue and serum lipocalin 2 in psoriasis vulgaris and its implications on subclinical atherosclerosis

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