Migraine madness: recurrent psychosis after migraine.

Abstract

A 69 year old man with longstanding migraine with aura had four episodes of psychosis lasting 7-28 days during a 17 year period. During attacks he had formed visual hallucination and delusions, including reduplicative paramnesia. His mother was similarly affected. His EEG showed symmetrical frontal delta waves. The time course and EEG changes are similar to acute confusional migraine. The reduplicative paramnesia suggests a focal non-dominant hemisphere dysfunction. (J Neurol Neurosurg Psychiatry 1993;56:416-418)

A variant of Capgras syndrome with delusional conviction of inanimate doubles in a patient with grandmal epilepsy

“…Fuller et al . suggested this phenomenon was related to a focal non‐dominant hemisphere dysfunction (10). Several other organic disorders including dementia, cerebrovascular disease, and epilepsy were thought to be associated with Capgras syndrome (11).…”

Familial Hemiplegic Migraine and Recurrent Episodes of Psychosis: A Case Report

“…We present a case report of a father and son with very similar phenotypes. To date, there have been few similar case reports published . It could be considered whether such cases truly are rare or more likely misdiagnosed and underreported.…”

“…To date, there have been few similar case reports published. [8][9][10][11][12] It could be considered whether such cases truly are rare or more likely misdiagnosed and underreported. To our knowledge, this is the first case in which no mutation was identified in a family with FHM and accompanying episodes of psychosis.…”

Familial Hemiplegic Migraine with Cerebellar Ataxia and Paroxysmal Psychosis

“…Since a dysfunction in serotonergic metabolism is also discussed as being involved in the physiopathology of schizophrenia [14, 15], it may be hypothesized that a disturbed 5-HT metabolism, caused by a genetically determined dysfunction of P/Q-type Ca 2+ channels, may be the pharmacological basis for psychotic episodes in some migraine individuals, which have previously been described in patients with FHM [16, 17]. A more detailed understanding of the mechanisms leading to psychotic episodes in FHM might open new insight into the pathophysiology of psychosis.…”