Migraine: Molecular Basis and Herbal Medicine

Ansari, Mohammad; Rafiee, Kheirollah; Emamgholipour, Solaleh; Fallah, Mohammad‐Sadegh

doi:10.5772/32018

Cited by 6 publications

(3 citation statements)

References 97 publications

(187 reference statements)

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“…According to the studies of scientists incidence, prevalence as well as the individual and social costs of headache are significantly high all over the world ( 1 ) especially in low and middle-income countries ( 2 ). While the prevalence of headache is more than 47% ( 3 ) utilization of proper and continuous management in the treatment of headache will reduce the personal and social expenditures of headache disorders ( 4 ). Because of the side effects resulting from the oral drugs, physicians tend to use other delivery mechanisms such as nasal delivery administration ( 5 ).…”

Section: Contextmentioning

confidence: 99%

Types of Nasal Delivery Drugs and Medications in Iranian Traditional Medicine to Treatment of Headache

Ghorbanifar¹,

Kasmaei²,

Minaei³

et al. 2014

Iran Red Crescent Med J

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Context:Headache is a common symptom throughout the world. The main purpose of patient-centered approaches is the utilization of useful and simple treatment. Nowadays, there is a rising propensity toward herbal remedies. Nasal route is one of the ancient and topical prescriptions used in headache. In Iranian traditional medicine, physicians such as Avicenna were prescribing herbal drugs through the nose to treat a variety of central nervous system diseases like headache.In this review paper, authors have attempted to introduce different types of nasal administrations which were used in Iranian traditional medicine for the treatment of headaches.Evidence Acquisition:Initially, we studied two different types of Canon and separated all herbs used in the treatment of headache. Next, all plants were classified according to the method of prescription. Then, we pick out all the plants which were nasally utilized in the treatment of headache and divided them based on the method of administration. In order to find scientific names of herbs, we used two different botany references. Moreover, we conducted various researches in scientific databases with the aim of finding results concerning the analgesic and antinociceptive effects of herbs. Throughout the research, key terms were “analgesic” and “antinociceptive “with the scientific names of all herbs separately. The databases searched included PubMed, Scopus, Cochrane library and SID.Results:35 plants were prescribed for the treatment of headaches, which were all nasally used. These plants took either the form of powder, liquid or gas (steam). They were divided in to six categories according to the method of prescription. The Percentage of usage for each method was as follows: 62% Saoot (nasal drop), 25% Shamoom (smell), 17% Inkabab (vapor), 11% Nafookh (snuff), 11% Nashooq (inhaling) and 2% Bokhoor (smoke).Conclusions:Medications that are used via nasal delivery have greater effect than oral medications. Iranian physicians were fully aware of systemic effects of topical medications, including prescription drugs through the nose. The study of ancient medical texts helps us in identification of herbal medicine and the investigation of new way for the preparation of drugs.

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Section: Contextmentioning

confidence: 99%

Types of Nasal Delivery Drugs and Medications in Iranian Traditional Medicine to Treatment of Headache

Ghorbanifar¹,

Kasmaei²,

Minaei³

et al. 2014

Iran Red Crescent Med J

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“…Chamomile hydrophilic compounds (polyphenolic compounds [Flavonoides] including apigenin as a major compound) inhibit the expression of NOS in active macrophages and can lead to inhibition of NO secretion and synthesis [60] . Such an effect can be seen in the essential oils of chamomile including chamazulene [61] and in addition, it can reduce inflammation in the workplace and reduce migraine pain. Chamomile is traditionally used for inflammation, pain, neuralgia, etc.…”

Section: Chamomilementioning

confidence: 99%

Herbal treatment for migraine

Patil¹,

Nikam²,

Milmile³

et al. 2021

Int. J. Pharmacognosy Life Sci.

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Migraine is a debilitating neurovascular disorder with a number of targeted, tolerant and effective treatments. The formulation made in plant-based plants, holds great promise in the identification of new therapeutic goals for migraine. Therefore, safety and performance tests are essential. We are reviewing some of the phytomedicines that may be useful in the treatment of migraine-feverfew (Tanacetum Parthenium), butterbur (Petasites hybridus), menthol (Mentha piperita), coriander (C. sativum), Ginkgobiloba (Gingko macrophylla K. Koch), Ginger (Zingiber officinale Rosc.), Matricaria chamomilla (Matricaria recutita), Curcumin (Curcuma longa), Lavender (Lavandula spica) in terms of their mechanisms and evidence of migraine treatment. The results of this systematic review suggest that many herbal remedies, through their many physiological influences, emerge as options for improving migraine treatment. However, other high-level studies are important to evaluate their effectiveness and safety as a treatment for migraine.

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“…of Iran (IRC1228143083). It has been previously reported that Migri-Heal ® reduces NO levels in endothelial cell culture (10). Therefore, the evaluation of the possible anti-inflammatory effects of Migri-Heal ® may be useful to illustrate other therapeutic aspects of this herbal remedy in neuroinflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Anti‑inflammatory effect of Migri‑Healï¿½ in an inï¿½vitro inflammatory model of primary mixed glial cells

et al. 2017

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Migri‑Heal®, is a novel herbal remedy that was introduced for the treatment of migraine headaches. Previous studies revealed that this drug may reduce nitric oxide (NO) in an in vitro inflammatory model. The aim of the present study was to investigate the anti‑inflammatory effect of Migri‑Heal® on primary mix glial cells stimulated with LPS. In the current study, neonatal rat primary mix glial cells were isolated from the mixed glial cultures via shaking, and cultured in Dulbecco's' modified Eagle's medium supplemented with 10% fetal bovine serum. Following pretreatment with Migri‑Heal® (25, 75, 100, 150, 200 and 300 µg/ml) and cells were treated with LPS (10 µg/ml) for 1 h, and incubated for 48 h. The present study determined that 150 µg/ml Migri‑Heal® signiﬁcantly reduced the production of NO in rat mix glial cells stimulated with 10 µg/ml LPS. Migri‑Heal® also suppressed mRNA expression level of LPS‑induced inducible nitric oxide synthase and tumor necrosis factor α, which was accompanied by inhibition of the transcription factor nuclear factor‑κB. Additionally, MTT assay determined that Migri‑Heal® was not cytotoxic, suggesting that the anti‑inflammatory effects of Migri‑Heal® observed were not due to cell death. In conclusion, the findings of the present study demonstrated that Migri‑Heal® may be useful as a potential anti‑inflammatory agent in inflammatory diseases. However, additional studies are required to confirm these findings.

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Migraine: Molecular Basis and Herbal Medicine

Cited by 6 publications

References 97 publications

Types of Nasal Delivery Drugs and Medications in Iranian Traditional Medicine to Treatment of Headache

Types of Nasal Delivery Drugs and Medications in Iranian Traditional Medicine to Treatment of Headache

Herbal treatment for migraine

Anti‑inflammatory effect of Migri‑Healï¿½ in an inï¿½vitro inflammatory model of primary mixed glial cells

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