Migrainous Vertigo: Mutation Analysis of the Candidate Genes CACNA1A, ATP1A2, SCN1A, and CACNB4

Brevern, Michael von; Ta, Nga; Shankar, Anupama; Wiste, Anna; Siegel, Anne; Radtke, A.; Sander, Thomas; Escayg, Andrew

doi:10.1111/j.1526-4610.2006.00504.x

Cited by 74 publications

(46 citation statements)

References 22 publications

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“…Analyses of candidate genes, however, have been negative in VM so far. 38,39 This study provides a longitudinal assessment of clinical symptoms and vestibulo-cochlear function in VM based on previously validated diagnostic criteria. 17 Diagnostic certainty was increased by repeat neurotologic assessment to rule out other causes of vertigo that had become apparent during follow-up.…”

Section: Resultsmentioning

confidence: 99%

Vestibular migraine

Radtke

Brevern²,

Neuhauser³

et al. 2012

Neurology

197

146

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The majority of patients continue to have recurrent vertigo in the long-term evolution of VM, and the impact of vertigo may remain severe. Whereas interictal ocular motor abnormalities may show some variation over time, vestibulo-cochlear dysfunction progresses slowly in some patients with VM. Interictal central-type PN may help distinguish VM from peripheral vestibular disorders such as Ménière disease.

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Section: Resultsmentioning

confidence: 99%

Vestibular migraine

Radtke

Brevern²,

Neuhauser³

et al. 2012

Neurology

197

146

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“…We suspect that the stable characteristics of central ocular motor disturbances are due to the treatment effects of prophylactic migraine medication. Possible causes of VM are vasospasms within the vestibular and/or auditory labyrinth [14,15,16] and dysfunction of voltage-sensitive ion channels or neurotransmitters alone or in combination with spreading depression [5,17,18,19,20,21,22]. Just as the pathophysiological mechanisms underlying VM have not yet been unraveled, it is also unclear how migraine prophylactics influence the course of the disease.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Changes of Central Ocular Motor Signs in Patients with Vestibular Migraine

Neugebauer¹,

Adrion

Glaser³

et al. 2012

Eur Neurol

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Background: A high percentage of patients with vestibular migraine (VM) were reported to have central ocular motor dysfunctions (COMD) in the symptom-free interval. Since VM is a chronic disorder, it is of interest if COMD worsen over time. Methods: Thirty VM patients and 11 control patients participated in an 8-year-long observational study with follow-up. All patients underwent standardized neuro-ophthalmological and neuro-otological examinations at the initial presentation and at follow-up. The primary outcome measure was change in COMD at follow-up. Results: In general, COMD in the symptom-free interval were subtle, consisting of a saccadic horizontal and/or vertical pursuit. At follow-up, significantly more patients with VM had COMD (p = 0.015). The prevalence of COMD increased from 20 to 63% in VM patients. Further, the presence of COMD at follow-up had a positive predictive value of 90.5% for the diagnosis of VM. Successful treatment with prophylactic migraine medication seems to prevent the development and worsening of COMD (p = 0.008). Conclusion: Mild COMD occur in a large percentage of VM patients during the course of the disease. The presence of COMD is predictive of VM in patients with recurrent attacks of vertigo. Prophylactic migraine medication seems to attenuate the development and progression of COMD.

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“…Until now, CACNA1A mutations have not been reported in children with isolated BPV, but literature data are scarce. In adult patients suffering from recurrent vertigo, large population screenings have been carried out but sequencing of different genes coding for ion channels did not reveal any deleterious abnormalities (20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%