Migration inhibition with various cell fractions in human colorectal cancer.

Armitstead, P R; Gowland, G.

doi:10.1136/gut.16.12.968

Cited by 8 publications

References 15 publications

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Cellular immunity in patients with colorectal adenocarcinoma measured by autologous leukocyte migration inhibition

Elias

Didolkar

et al. 1977

Cancer

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The leukocyte migration inhibition test (LMT) was utilized for in vitro study of tumor-specific cell-mediated immunity in 62 patients with various stages of colorectal adenocarcinoma. These patients underwent exploratory laparotomy for curative or palliative resections and were staged surgically and pathologically according to Dukes classification. Autologous tumor and mucosa were obtained from their surgical specimens and its homogenates were used for autologous LMT initially, i.e., on the day of surgery, and stored for the followup studies utilizing freshly obtained autologous peripheral blood. The results showed that patients with localized or regional disease were initially hypersensitized to their tumors when compared with those with disseminated disease. However, the follow-up studies expressed loss of such hypersensitivity. This could explain a possible mechanism for the development of metastasis and might provide an "escape" mechanism for the tumor immune response in the host on the cellular level similar to that described in the sera by Hellstrom and Halliday. These findings might reflect on immunotherapy in patients with regional or local disease after their curative surgery. For passive immunization, the lymphocytes should be obtained from these patients prior to surgery. Active or passive immunization could then be administered in the postoperative period and monitored by LMT.Cancer 40:687-692,1977. E HAVE PREVIOUSLY REPORTED ON THEW use of autologous leukocyte migration test (LMT) in the in vitro assay of tumor-specific cellular immunity in human malignancies. ' It was also shown that patients with adenocarcinoma of the colon and rectum expressed hypersensitivity toward their tumors by utilizing the LMT, and that such hypersensitivity was specific to the tumor, as neither leukocytes from normal healthy volunteers nor normal mucosa could express inhibition in such assays.'.' In these two previous reports, we have also shown that patients with localized or regional diseases expressed hypersensitivity toward their tumors on the day of surgery, a phenomena that seemed

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Cellular immunity in patients with colorectal adenocarcinoma measured by autologous leukocyte migration inhibition

Elias

Didolkar

et al. 1977

Cancer

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A modified leukocyte adherence inhibition test in the laboratory investigation of gastrointestinal cancer

Rutherford¹,

Walters²,

Cavaye³

et al. 1977

Intl Journal of Cancer

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A modification of the leukocyte adherence inhibition (LAI) technique has been used to test 60 hospital patients with gastrointestinal symptoms, for specific immunoreactivity against extracts of tumours of colon, pancreas and stomach. The modified technique employed mononuclear cells and soluble tumour extracts in glass test tubes, the non-adherent cells being enumerated in an electronic counter. Laboratory tests were completed before the eventual diagnosis was known. Groups of patients with adenocarcinoma of colon or rectum (11), carcinoma of pancreas (3) and adenocarcinoma of stomach (6) were clearly distinguished from each other and from patients with non-malignant diseases or with neoplasms of different histological type.

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Relation between immunity and survival in carcinoma of the colon and rectum

Greco

1979

The American Journal of Surgery

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Migration inhibition with various cell fractions in human colorectal cancer.

Cited by 8 publications

References 15 publications

Cellular immunity in patients with colorectal adenocarcinoma measured by autologous leukocyte migration inhibition

Cellular immunity in patients with colorectal adenocarcinoma measured by autologous leukocyte migration inhibition

A modified leukocyte adherence inhibition test in the laboratory investigation of gastrointestinal cancer

Relation between immunity and survival in carcinoma of the colon and rectum

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