Mikro- und Nanosystemtechnik – medizintechnologische Aspekte am Beispiel eines Blasendrucksensors

Clasbrummel, B.; Muhr, G.; Jettkant, Birger; Dehm, Johannes; Schlierf, R; Mokwa, Winfried; Möllenhoff, G.

doi:10.1159/000089346

Cited by 3 publications

(6 citation statements)

References 6 publications

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“…[12,25] Clasbrummel et al have independently proposed a similar wireless system as described in this study. [15] Majerus et al have also reported their work on a pressure sensor for submucosal implantation with wireless battery recharging. [14,26] In this study, we have demonstrated the feasibility of wireless induction in vivo for pressure measurement using a catheterless device in the bladder lumen for both power and real-time data communications.…”

Section: Discussionmentioning

confidence: 99%

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Wireless intravesical device for real-time bladder pressure measurement: Study of consecutive voiding in awake minipigs

et al. 2019

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Traditional urodynamics have poor correlation with urological symptoms. Ambulatory urodynamics may improve this correlation but the need for a transurethral catheter and the time-consuming nature of this examination limits its use. Therefore, the objective of this study was to develop a wireless real-time bladder pressure measurement device for repeated and prolonged-term measurement of bladder behavior in awake pigs. The Bladder Pill is an intravesical device with a pressure microsensor and a 3-dimensional inductive coupling coil for energy supply. A corresponding external coil provides wireless power transmission and real-time communication of bladder pressure data. To test the correlation between the pressure data measured by the device and by standard methods, we compared static water column pressures with this device and water-filled urodynamic catheter systems. In vivo assessment of awake voiding by the pill was done by introducing the bladder pill into the bladder of Göttingen minipigs. An air-charged urodynamic catheter was introduced transurethrally as control for pressure measurements. The optimal physical configuration of the pill was investigated to maximize the containment in the bladder. We used two versions of external signal receivers (one waistband and one rectangular frame) to test the optimal external signal capture. Next to that, we performed short-term and medium-term comparative pressure studies. The in vitro static pressure measurement demonstrated a mean difference of less than 1 cm H2O between the methods. The optimal design of the pill for maximal retainment in the bladder proved to be a pigtail configuration. The bending of the device during bladder contractions caused offset of 2.7 +/- 1.4 cm H2O (mean +/- SD) on the pressure measurements. The rectangular frame performed signal capture during 5 consecutive voids with a good correlation of the pressure measurements. The device can be inserted through the urethra and is retrieved using string or endoscopic extraction. In conclusion, wireless long-term measurement of bladder pressure is demonstrated and yields comparable results to current available catheter methods of measurement in a pig model.

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Section: Discussionmentioning

confidence: 99%

“…Several implantable devices based on pressure microsensors have been proposed as alternative to catheters. [11–15] Key features of these devices are data readout and power supply which both contribute to the device dimensions. Other problems in common with catheters are the insertion methods and intravesical retainment mechanism.…”

Section: Introductionmentioning

confidence: 99%

Wireless intravesical device for real-time bladder pressure measurement: Study of consecutive voiding in awake minipigs

et al. 2019

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“…Clasbrummel and Muhr [5] suggested suturing the system inside the bladder; other systems are large enough that expulsion is impossible, but they are not installable through a cystoscope. Some authors have not provided any information how to prevent an expulsion [9].…”

Section: Discussionmentioning

confidence: 99%

Catheterless Long-Term Ambulatory Urodynamic Measurement Using a Novel Three-Device System

Wille

Schumacher²,

Paas

et al. 2014

PLoS ONE

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AimsLong-term urodynamics are required because bladder-emptying disorders are often not clearly revealed by conventional urodynamics. Patients with severe clinical overactive bladder symptoms, for instance, often show normal results. This may be due to the short evaluation time and psychological factors that complicate conventional urodynamics. This study aimed to develop an ambulatory three-component urodynamic measurement system that is easy to operate, registers urodynamic parameters for several days, and has no negative impact on the patient.MethodsWe developed an intravesical capsule combined with a hand-held device to register voiding desire and micturition, and an alarm pad device that detects urine loss. Recently, the intravesical capsule and its proven function were detailed in the literature. Here, we present detailed in vitro results using a female bladder model. The flexible capsule was C-shaped to minimize the risk of expulsion from the bladder during micturition. Results of biocompatibility evaluation of the intravesical capsule, which is called Wille Capsule (WiCa) are described.ResultsThe WiCa with an oval nose and a maximum outer diameter of 5.5 mm was easily inserted through a 25-French cystoscope. Removing the WiCa by grasping the nose using the female model with bladder was easily conducted. Expulsion of the WiCa during voiding was avoided through a novel C-shaped device design. Based on in vitro cytotoxicity studies, the capsule is a promising and safe device.ConclusionOur novel system is an innovative minimally-invasive tool for accurate long-term urodynamic measurement, and does not require inserting a transurethral catheter.

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“…The catheterless pressure measurement is generally of great interest for many medical applications such as intracranial pressure measurement [3] or real-time blood pressure measurement [4]. Some devices have been designed especially for the intravesical pressure measurement [5][6][7][8]. Implantable measurement systems have to be very small, so that the power supply is one of the most crucial topics.…”

Section: Catheterless Pressure Measurementmentioning

confidence: 99%

“…It has to be ensured that the system is not expulsed from of the bladder during micturition. Clasbrummel [7] suggested suturing the system inside the bladder, other systems are too large so that an expulsion is impossible [6], but they are not implantable through a cystoscope. Some authors give no information how to prevent an expulsion [8].…”

Section: Catheterless Pressure Measurementmentioning

confidence: 99%

A new catheterless urodynamics measurement method by using an intravesical capsule

Hamacher¹,

Tenholte²,

Schumacher³

et al. 2012

Biomedical Engineering / Biomedizinische Technik

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Urodynamics is considered as a standard diagnostic test for urinary incontinence using catheter tip sensors to measure the bladder pressure. Standard urodynamic measurement takes about 30 minutes, thus it is often not possible to monitor pathological change of pressure during this short period of time. In addition, different psychosocial factors could affect the result of standard urodynamics. In this paper we describe a new system for catheterless urodynamic measurement. The system consists of an implantable intravesical capsule that measures the pressure over a period of up to 72 hours. The system needs no components outside of the human body, so an outpatient treatment is possible, which allows measurements under conditions of the patient's daily routine.

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Mikro- und Nanosystemtechnik – medizintechnologische Aspekte am Beispiel eines Blasendrucksensors

Cited by 3 publications

References 6 publications

Wireless intravesical device for real-time bladder pressure measurement: Study of consecutive voiding in awake minipigs

Wireless intravesical device for real-time bladder pressure measurement: Study of consecutive voiding in awake minipigs

Catheterless Long-Term Ambulatory Urodynamic Measurement Using a Novel Three-Device System

A new catheterless urodynamics measurement method by using an intravesical capsule

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