Mikrophotographische Darstellung der wirklichen interstitiellen Zellen von Cajal

Jabonero, V.; Carrato, Alfredo; Jabonero, R M; Giron, Felipe; Martinez, Robert; Moya, J.

doi:10.1007/bf01237112

Cited by 6 publications

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“…The cells fitting the description and presumed location of ICC described by Dr. Cajal were composed of fibroblast-like cells, a great disappointment to the earlier investigators trying to assign an important physiologic function [31][32][33][34][35]. Later investigators found that some smooth muscle cells had a peculiar arrangement and shape in contact with many other smooth muscle cells, topographically fitting for signal transmitting cells.…”

Section: Discussionmentioning

confidence: 95%

Gastrointestinal Stromal Tumor: An Ultrastructural Investigation on Regional Differences with Considerations on Their Histogenesis

Min

2010

Ultrastructural Pathology

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Gastrointestinal stromal tumor (GIST) is the most frequent spindle cell tumor in the gastrointestinal tract and may arise from esophagus to rectum. The stomach is the most frequent site, followed by small intestine, rectum, and esophagus. There have been some regional differences reported in their histopathologic and clinical presentations. The purpose of this study is to compare ultrastructural features of GIST, according to its anatomic site, in order to provide additional data to support the current concept of its histogenesis. Fifty-four GISTs (27 from stomach, 23 from small intestine, and 4 from rectum) were included in the study. Histopathologically, gastric GISTs tended to be more frequently epithelioid, particularly those in children, while small intestinal GISTs (SISTs) were mostly spindly in all but three cases. All four of the rectal GISTs were spindly. Ultrastructurally, there seem to be considerable regional differences. In the majority of gastric GISTs, in both epithelioid and spindle types, tumor cells exhibited focal features of myoid differentiation evidenced by the presence of incomplete external lamina (EL) and/or focal accumulations of thin fibers with interrupted electron densities consistent with actin filaments. However, features of myoid differentiation were exceptional for SISTs and rectal GISTs, being present in only one example in each. Some gastric GISTs, particularly those having an epithelioid appearance, showed cell borders luxuriously decorated by long filopods (anemone cell features). Anemone cell features were also present in spindle cell types of gastric GISTs as well as SISTs, albeit it was simpler and less luxuriant. Skeinoid fibers were present in the majority of SISTs and rectal GISTs, but absent in all gastric GISTs except one. These differences appeared to be too significant to propose a uniform histogenesis for all GISTs. Nevertheless, on closer analysis, certain features could be identified to explain a line of differentiation in all GISTs ranging from (1) polygonal uncommitted epithelioid mesenchymal cells with cell borders decorated by luxuriant fimbria, to (2) spindly tumor cells with less prominent fimbria, or (3) cells with or without features of minimum myoid differentiation characterized by the focal presence of cytoplasmic actin fibers or incomplete EL or skeinoid fibers, which might represent an altered product of EL protein. These findings led the author to speculate that the probable primordial cells of GIST may be the primitive mesenchymal cells, which have the potential to differentiate into myoid cells. In this regard, it is important to note that the putative primordial cell of GIST, interstitial cells of Cajal (ICC), and intestinal smooth muscle cells have been shown to develop from the common progenitor cells of the primitive gut, and c-Kit plays a crucial role in the determination of their fate to differentiate to muscle cells or ICC. The author concludes that all GISTs derive from stem cells in the gut retaining some of the differentiation potential se...

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Section: Discussionmentioning

confidence: 95%

Gastrointestinal Stromal Tumor: An Ultrastructural Investigation on Regional Differences with Considerations on Their Histogenesis

Min

2010

Ultrastructural Pathology

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“…9 Similar considerations lead Jabonero (1965) to re-investigate ''die wirklichen interstitiellen Zellen von Cajal'' by studying and presenting micrographs of Cajal's original preparations. Recently, DeFelipe and Jones (1992) discuss the techniques employed by Cajal, and Boyde (1992) presents 3-D confocal microscopy images of Cajal's original Golgi preparations.…”

Section: The Period 1960-1980: Electron Microscopy-down To Earthmentioning

confidence: 96%

One hundred years of interstitial cells of Cajal

Thuneberg

1999

Microsc. Res. Tech.

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“…The cytomorphology and anatomic relationships of ICC in the intestine have been amply confirmed [21][22][23]. However, it is important to remember that ICC are located along the nerves in the interstitium.…”

Section: Cytomorphologymentioning

confidence: 99%

Interstitial Cells of Cajal (ICC) and Gastrointestinal Stromal Tumor (GIST): facts, speculations, and myths

Min

Leabu

2006

Journal of Cellular and Molecular Medicine

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Interstitial cells of Cajal (ICC) is a peculiar cell network composed of cells having processes described by the eminent Spanish neuroanatomist of the 19 th century, S. Ramon y Cajal. ICC became a fascinating subject to many investigators and it is estimated that there are over 100 publications yearly on the subject related to ICC, in the last three years. Now it is widely accepted that ICC are pace maker cells of the gut and probable progenitor cells of gastrointestinal stromal tumors (GIST). Lately, interstitial Cajal-like cells (ICLC) are being found in various organs and their physiological role is still to be defined. We have reviewed the literature trying to evaluate the validity of the current concept and found that there are a few salient points to be considered. 1) There has been some important departure in defining the identity of ICC from the original criteria of Cajal. In particular, ICC with myoid feafures in intestinal smooth muscle layers (ICC-DPM) do not seem to fit to the original description of interstitial cell network by Cajal. We have also pointed out that the current reports assigning a pace maker role to ICC vastly depend on the scientific data on "ICC with myoid features", not on "fibroblast-like ICC", which are more abundant and easier to identify. 2) There seem to be an overwhelming amount of data proving the relationship between ICC and GIST. Both are known to express c-Kit and the ultrastructural characteristics seen in GIST roughly parallel those of ICC including minimal myoid differentiation seen in the majority of GIST, supporting the current concept that GIST are ICC tumors. 3) According to the original description of Cajal, ICC was not limited to the gut, suggesting an existence of ICC in other organs. The list of organs reported to contain ICC (currently identified by immunohistochemistry and electron microscopy) is ever growing and further studies are needed to define their identity and pathophysiologic role. 4). Recent data concerning gut development suggest that both c-Kit expressing ICC (fibroblasts-like as well as muscle-like) and gut muscle cells Their physiologic role was not clear at that time and even today, but Cajal speculated on a possible ancillary neural function, because of their anatomic proximity and morphologic similarity to nerves. In fact, interstitial cells of the gut are neither neural nor muscular, but are interposed between nerve and muscle cells. He considered that they might play a controlling function of the gut motility, and he thereby stimulated many investigators to study his concept. Consequently, a vast amount of data has been accumulated on 1) their existence, 2) the ultrastructural characterization of a possible pacemaker role in the gut, 3) electrophysiologic studies of peristalsis, 4) c-Kit as a molecular marker of ICC, and 5) as progenitor cells of gastrointestinal stromal tumors (GIST). The data thus far accumulated is vast and complex, but has promulgated the definition and identification of ICC [19].In recent years, much interesti...

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Mikrophotographische Darstellung der wirklichen interstitiellen Zellen von Cajal

Cited by 6 publications

References 0 publications

Gastrointestinal Stromal Tumor: An Ultrastructural Investigation on Regional Differences with Considerations on Their Histogenesis

Gastrointestinal Stromal Tumor: An Ultrastructural Investigation on Regional Differences with Considerations on Their Histogenesis

One hundred years of interstitial cells of Cajal

Interstitial Cells of Cajal (ICC) and Gastrointestinal Stromal Tumor (GIST): facts, speculations, and myths

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