Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease

Gagnon, Jean‐François; Vendette, Mélanie; Postuma, Ronald B.; Desjardins, Catherine; Massicotte-Marquez, Jessica; Panisset, Michel; Montplaisir, Jacques

doi:10.1002/ana.21680

Cited by 307 publications

(298 citation statements)

References 39 publications

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“…With long term follow-up, more than 80% of individuals with idiopathic RBD developed either Parkinson's disease (PD), dementia with Lewy bodies (DLB) or multiple system atrophy (MSA) ,Schenck, et al, 2013. It was suggested that RBD may define a subtype of PD patients (Fereshtehnejad, et al, 2015,Gagnon, et al, 2004 with cognitive decline (Gagnon, et al, 2009,Vendette, et al, 2007, dementia (Anang, et al, 2014), hallucinations (Sixel-Doring, et al, 2011) and autonomic dysfunction (Postuma, et al, 2008), as compared to PD patients without RBD. In addition, pathological studies in brains of PD patients with and without RBD demonstrated a more widespread -synuclein accumulation in those associated with RBD .…”

Section: Introductionmentioning

confidence: 99%

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

Gan‐Or

Montplaisir

Ross

et al. 2017

Neurobiology of Aging

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The dementia-associated APOE ε4 allele is not associated with REM sleep behavior disorder, Neurobiology of Aging (2016Aging ( ), doi: 10.1016Aging ( /j.neurobiolaging.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPTAbstract: The current study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic REM sleep behavior disorder (RBD). Two SNPs, rs429358 and rs7412, were genotyped in RBD patients (n=480) and in controls (n=823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR=1.11, 95% CI 0.88-1.40, p=0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to PD (0.12) or multiple system atrophy (0.14, p=1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.

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Section: Introductionmentioning

confidence: 99%

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

Gan‐Or

Montplaisir

Ross

et al. 2017

Neurobiology of Aging

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“…The cognitive tests and variables included measures of three main cognitive domains: (1) attention and executive functions [digit span from the Wechsler Adult Intelligence Scale III (scaled score); a modified version of the Stroop Color Word Test (part III minus part I for times or errors) [32]; the trail-making test, part B (times); the semantic (animals, fruits/vegetables) and phonemic (P, F and L) verbal fluency test (number of items in 1 min)], (2) episodic verbal learning and memory [Rey Auditory Verbal Learning Test (sum of trials 1–5, list B, immediate recall, delayed recall and recognition)] and (3) visuospatial abilities [copy of the Rey-Osterrieth figure; block design from the Wechsler Adult Intelligence Scale III (scaled score); Bell test (number of omissions)] [22,33]. …”

Section: Methodsmentioning

confidence: 99%

“…Idiopathic RBD (iRBD) is a risk factor for the development of synucleinopathies such as Lewy body dementia, multiple system atrophy and PD [21]. Moreover, MCI affects approximately 50% of iRBD patients [22]. The validity of the MMSE to detect MCI in RBD is poor [23].…”

Section: Introductionmentioning

confidence: 99%

Validity of the Mattis Dementia Rating Scale to Detect Mild Cognitive Impairment in Parkinson’s Disease and REM Sleep Behavior Disorder

Villeneuve

Rodrigues-Brazète

Joncas

et al. 2011

Dement Geriatr Cogn Disord

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Background/Aims: Mild cognitive impairment (MCI) is frequent in Parkinson’s disease (PD) and idiopathic REM sleep behavior disorder (iRBD). However, only a few studies have evaluated the validity of brief cognitive measures to detect MCI in PD or iRBD using standard diagnostic criteria for MCI. Our aim was to evaluate the validity of the Mini-Mental State Examination (MMSE) and the Mattis Dementia Rating Scale (DRS-2) to detect MCI in PD and iRBD. Methods: Forty PD patients and 34 iRBD patients were studied. Receiver operating characteristic curves were created for both tests to assess their effectiveness in identifying MCI in PD and iRBD. Results: In PD, a normality cutoff of 138 on the DRS-2 yielded the best balance between sensitivity (72%) and specificity (86%) with a correct classification of 80%. In iRBD, the optimal normality cutoff was 141 on the DRS-2, with a sensitivity of 90%, a specificity of 71% and a correct classification of 82%. No cutoff for the MMSE was found to have acceptable sensitivity or specificity. Conclusion: The DRS-2 has satisfactory validity to detect MCI in PD or iRBD. The MMSE proved to be invalid as a screening test for MCI in both populations.

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“…Autonomic-orthostatic, urinary, erectile, bowel symptoms from the MSA rating scale 18 orthostatic hypotension tested using manual measurement, supine and after 1 minute standing 5. Cognitive testing-annual neuropsychological examination (outlined elsewhere 19 ) evaluating dementia/mild cognitive impairment (MCI), 19 Analysis. Disease risk was estimated with Kaplan-Meier analysis.…”

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confidence: 99%

Parkinson risk in idiopathic REM sleep behavior disorder

et al. 2015

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Objective: To precisely delineate clinical risk factors for conversion from idiopathic REM sleep behavior disorder (RBD) to Parkinson disease, dementia with Lewy bodies, and multiple system atrophy, in order to enable practical planning and stratification of neuroprotective trials against neurodegenerative synucleinopathy.Methods: In a 10-year prospective cohort, we tested prodromal Parkinson disease markers in 89 patients with idiopathic RBD. With Kaplan-Meier analysis, we calculated risk of neurodegenerative synucleinopathy, and using Cox proportional hazards, tested the ability of prodromal markers to identify patients at higher disease risk. By combining predictive markers, we then designed stratification strategies to optimally select patients for definitive neuroprotective trials.Results: The risk of defined neurodegenerative synucleinopathy was high: 30% developed disease at 3 years, rising to 66% at 7.5 years. Advanced age (hazard ratio [HR] 5 1.07), olfactory loss (HR 5 2.8), abnormal color vision (HR 5 3.1), subtle motor dysfunction (HR 5 3.9), and nonuse of antidepressants (HR 5 3.5) identified higher risk of disease conversion. However, mild cognitive impairment (HR 5 1. REM sleep behavior disorder (RBD) is characterized by loss of REM sleep paralysis, allowing patients to "act out" dreams.

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Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease

Abstract: In both its association with PD and its idiopathic form, RBD is an important risk factor for MCI. Except for visuoconstructional and visuoperceptual problems, RBD may be an important determinant of cognitive impairment in PD. Ann Neurol 2009;66:39-47.

Cited by 307 publications

References 39 publications

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

Validity of the Mattis Dementia Rating Scale to Detect Mild Cognitive Impairment in Parkinson’s Disease and REM Sleep Behavior Disorder

Parkinson risk in idiopathic REM sleep behavior disorder

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