Mild exercise activates renal dopamine system in mild hypertensives

Sakai, Takaaki; Ideishi, Munehito; Miura, Shin‐ichiro; Maeda, Hirokazu; Tashiro, E; Koga, Monji; Kinoshita, Akio; Sasaguri, Manabu; Tanaka, Hiroaki; Shindo, Munehiro; Arakawa, Kikuo

doi:10.1038/sj.jhh.1000608

Cited by 24 publications

(14 citation statements)

References 39 publications

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“…Miura et al [45], observed an increase in the levels of urinary kallikrein of hypertensive individuals submitted to 10 weeks of training in a cycloergometer. Sakai et al [46] showed that four weeks of exercise practice was able to reduce blood pressure and to increase 2-fold urinary kallikrein activity. Furthermore, we could also demonstrate that an acute exercise bout also was able to promote blood pressure reduction [9].…”

Section: Discussionmentioning

confidence: 98%

Kallikrein kinin system activation in post-exercise hypotension in water running of hypertensive volunteers

Pontes

Bacurau

Moraes

et al. 2008

International Immunopharmacology

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Section: Discussionmentioning

confidence: 98%

Kallikrein kinin system activation in post-exercise hypotension in water running of hypertensive volunteers

Pontes

Bacurau

Moraes

et al. 2008

International Immunopharmacology

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“…Normotensive subjects with a family history of hypertension have decreased urinary dopamine (523, 562), an impaired dopamine response to sodium loading (96,517), and a reduction in the conversion of l -DOPA to dopamine. Interestingly, mild exercise has been reported to increase renal dopamine production in Stage 1 hypertensive subjects (525). …”

Section: Structure and Function Of The Renal Dopaminergic Systemmentioning

confidence: 99%

Dopamine and Renal Function and Blood Pressure Regulation

Armando

Villar

José

2011

Comprehensive Physiology

108

215

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Dopamine is an important regulator of systemic blood pressure via multiple mechanisms. It affects fluid and electrolyte balance by its actions on renal hemodynamics and epithelial ion and water transport and by regulation of hormones and humoral agents. The kidney synthesizes dopamine from circulating or filtered L-DOPA independently from innervation. The major determinants of the renal tubular synthesis/release of dopamine are probably sodium intake and intracellular sodium. Dopamine exerts its actions via two families of cell surface receptors, D1-like receptors comprising D1R and D5R, and D2-like receptors comprising D2R, D3R, and D4R, and by interactions with other G protein-coupled receptors. D1-like receptors are linked to vasodilation, while the effect of D2-like receptors on the vasculature is variable and probably dependent upon the state of nerve activity. Dopamine secreted into the tubular lumen acts mainly via D1-like receptors in an autocrine/paracrine manner to regulate ion transport in the proximal and distal nephron. These effects are mediated mainly by tubular mechanisms and augmented by hemodynamic mechanisms. The natriuretic effect of D1-like receptors is caused by inhibition of ion transport in the apical and basolateral membranes. D2-like receptors participate in the inhibition of ion transport during conditions of euvolemia and moderate volume expansion. Dopamine also controls ion transport and blood pressure by regulating the production of reactive oxygen species and the inflammatory response. Essential hypertension is associated with abnormalities in dopamine production, receptor number, and/or posttranslational modification.

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“…BP was reduced by Ϫ8.8 (95% CL, Ϫ11.0 to Ϫ6.6)/Ϫ7.1 (95% CL, Ϫ8.6 to Ϫ5.5) mm Hg in these study groups (PϽ0.001). The 10 study groups [17][18][19]22,24,59,62,63 that reported on plasma renin activity (PRA) showed a significant decrease of PRA by 19.8% (95% CL, Ϫ35.0 to Ϫ4.7; PϽ0.05); the BP changes averaged Ϫ10.6 (95% CL, Ϫ13.9 to Ϫ7.3)/Ϫ7.0 (95% CL, Ϫ8.9 to Ϫ5.1) mm Hg (PϽ0.001).…”

Section: Changes In Plasma Norepinephrine and Plasma Renin Activitymentioning

confidence: 99%

“…Ten normotensive, 11,31,42,49,56,69 18 prehypertensive, § and 3 hypertensive study groups 23,45,79 gave no information on antihypertensive medication. Participants had been taken off medication in 2 and 6 prehypertensive 40 and hypertensive study groups, 16,19,26,29,59,64 respectively; 6 hypertensive study groups 14,30,46,54,61,71 reported that all or some of their participants were on treatment during the study. As shown in Table 1, hypertensive participants were significantly older and had a higher body mass index (BMI) than participants from other subgroups.…”

Section: Overview Of Trialsmentioning

confidence: 99%

Effects of Endurance Training on Blood Pressure, Blood Pressure–Regulating Mechanisms, and Cardiovascular Risk Factors

2005

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Abstract-Previous meta-analyses of randomized controlled trials on the effects of chronic dynamic aerobic endurance training on blood pressure reported on resting blood pressure only. Our aim was to perform a comprehensive meta-analysis including resting and ambulatory blood pressure, blood pressure-regulating mechanisms, and concomitant cardiovascular risk factors. Inclusion criteria of studies were: random allocation to intervention and control; endurance training as the sole intervention; inclusion of healthy sedentary normotensive or hypertensive adults; intervention duration of Ն4 weeks; availability of systolic or diastolic blood pressure; and publication in a peer-reviewed journal up to December 2003. The meta-analysis involved 72 trials, 105 study groups, and 3936 participants. After weighting for the number of trained participants and using a random-effects model, training induced significant net reductions of resting and daytime ambulatory blood pressure of, respectively, 3.0/2.4 mm Hg (PϽ0.001) and 3.3/3.5 mm Hg (PϽ0.01). The reduction of resting blood pressure was more pronounced in the 30 hypertensive study groups (Ϫ6.9/Ϫ4.9) than in the others (Ϫ1.9/Ϫ1.6; PϽ0.001 for all). Systemic vascular resistance decreased by 7.1% (PϽ0.05), plasma norepinephrine by 29% (PϽ0.001), and plasma renin activity by 20% (PϽ0.05). Body weight decreased by 1.2 kg (PϽ0.001), waist circumference by 2.8 cm (PϽ0.001), percent body fat by 1.4% (PϽ0.001), and the homeostasis model assessment index of insulin resistance by 0.31 U (PϽ0.01); HDL cholesterol increased by 0.032 mmol/L Ϫ1 (PϽ0.05). In conclusion, aerobic endurance training decreases blood pressure through a reduction of vascular resistance, in which the sympathetic nervous system and the renin-angiotensin system appear to be involved, and favorably affects concomitant cardiovascular risk factors. Key Words: exercise Ⅲ blood pressure Ⅲ risk factors R egular physical activity is considered a cornerstone in the prevention and management of hypertension. 1-3 Epidemiological studies indicate that greater physical activity or fitness is associated with a lower blood pressure (BP), and meta-analyses of randomized controlled trials have shown that chronic dynamic aerobic endurance training is able to reduce BP. 3 Previous meta-analyses, including the most recent ones, 4 -6 focused on resting BP and did not report on other outcomes, such as ambulatory BP monitoring (ABPM), mechanisms to explain the BP-lowering effect of exercise, and the influence on concomitant risk factors. The number of eligible randomized controlled trials and study groups has since substantially increased, which allows a more precise estimate of the overall effect of exercise training, more powerful subgroup analyses, and analyses of the determinants of the response. Moreover, a number of studies reported on ambulatory BP, BP-regulating mechanisms, and other cardiovascular risk factors. Therefore, the main aims of the current meta-analysis were to examine the influence of chronic dynamic aerobic endura...

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Mild exercise activates renal dopamine system in mild hypertensives

Cited by 24 publications

References 39 publications

Kallikrein kinin system activation in post-exercise hypotension in water running of hypertensive volunteers

Kallikrein kinin system activation in post-exercise hypotension in water running of hypertensive volunteers

Dopamine and Renal Function and Blood Pressure Regulation

Effects of Endurance Training on Blood Pressure, Blood Pressure–Regulating Mechanisms, and Cardiovascular Risk Factors

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