2015
DOI: 10.1128/mcb.00579-15
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Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation

Abstract: c Environmental conditions control rRNA transcription. Previously, we found that serum and glucose deprivation induces KDM2A-mediated H3K36me2 demethylation in the rRNA gene (rDNA) promoter and reduces rRNA transcription in the human breast cancer cell line MCF-7. However, the molecular mechanism and biological significance are still unclear. In the present study, we found that glucose starvation alone induced the KDM2A-dependent reduction of rRNA transcription. The treatment of cells with 2-deoxy-D-glucose, a… Show more

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Cited by 50 publications
(75 citation statements)
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“…As such, it has been shown to promote tumourigenesis in lung [35] and gastric [36] cancers, and more recently an oncogenic isoform of KDM2A has been identified in breast cancer [26]. However, KDM2A has also been shown to repress rRNA transcription, a process required for cell proliferation [37,38]; also, when phosphorylated by ataxia-telangiectasia mutated (ATM), KDM2A helps in DNA damage repair [39]. Interestingly, HIF-1α also has dual roles in cancer, being important for tumourigenesis in cancer such as colon and breast [2,40], but acting more as a tumour suppressor in cancers such as renal clear cell cancer [41].…”
Section: Discussionmentioning
confidence: 99%
“…As such, it has been shown to promote tumourigenesis in lung [35] and gastric [36] cancers, and more recently an oncogenic isoform of KDM2A has been identified in breast cancer [26]. However, KDM2A has also been shown to repress rRNA transcription, a process required for cell proliferation [37,38]; also, when phosphorylated by ataxia-telangiectasia mutated (ATM), KDM2A helps in DNA damage repair [39]. Interestingly, HIF-1α also has dual roles in cancer, being important for tumourigenesis in cancer such as colon and breast [2,40], but acting more as a tumour suppressor in cancers such as renal clear cell cancer [41].…”
Section: Discussionmentioning
confidence: 99%
“…While 10 mM 2-DG treatment leads to the loss of TIF-IA in the rDNA promoter, 2 mM treatment does not even though such treatment also activates AMPK and suppresses pre-rRNA synthesis. Activated AMPK can also suppress pre-rRNA synthesis through KDM2A-dependent reduction of pre-rRNA synthesis [64]. …”
Section: The Regulation Of Tif-ia Function By Oncogenic Kinasesmentioning
confidence: 99%
“… a Wang et al (2014); b Lloret-Llinares et al (2012); c Lauberth et al (2013); d Chen et al (2015); e Audergon et al (2015); f Zhu et al (2010); g El Gazzar et al (2008); h Arnoult et al (2012); i Deng et al (2015); j De Santa et al (2009); k Agger et al (2009); l Tanaka et al (2015); m Suzuki et al (2016); n Sen et al (2015); o Jack et al (2013); p Jørgensen et al (2013); q Shinchi et al (2015); r Stender et al , 2012. …”
Section: Figurementioning
confidence: 99%