Mild head injury—a close relationship between motor function at 1 week post-injury and overall recovery at 3 and 6 months

Heitger, Marcus; Jones, Richard D.; Dalrymple‐Alford, John C.; Frampton, Chris; Ardagh, Michael; Anderson, Tim

doi:10.1016/j.jns.2006.11.007

Cited by 29 publications

(22 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may be owing to the small number of saccades elicited (44 per patient), and certainly to the diluting effect of comparing patient and control groups rather than using data from before and after concussion in individual subjects (individual latency distributions are idiosyncratic but highly reproducible). Indeed, in the follow-up study,13 they found a close relationship between mean latency within 1 week and level of self-perceived recovery within the first 6 months after injury.…”

Section: Discussionmentioning

confidence: 85%

Saccadometry: the possible application of latency distribution measurement for monitoring concussion

et al. 2007

View full text Add to dashboard Cite

Premature return to play after concussion may have debilitating or even fatal consequences. Computerised neuropsychological test batteries are widely used to monitor recovery, but none meet all specified criteria. One possible alternative is to measure saccadic reaction time or latency. Latency reflects the operation of cerebral decision mechanisms, and is strongly influenced by many agents that impair cortical function. A portable, micro-miniature device (saccadometer) was used to record the eye movements of amateur boxers before and after competitive bouts. Individual latency distributions were significantly affected after blows to the head, though the effects seemed to be reversible, with recovery over a few days. This quantitative, objective and easy to use technique should perhaps be deployed more widely to evaluate its potential in monitoring the effects of sports-related head injuries.

show abstract

Section: Discussionmentioning

confidence: 85%

Saccadometry: the possible application of latency distribution measurement for monitoring concussion

et al. 2007

View full text Add to dashboard Cite

show abstract

“…In a broader scope, eye movements and the upper limb have been sensitive markers of cerebral injury when examining visuomotor skill (131). Additionally, function of the eye and arm following acute ABI can predict outcomes in the subacute and chronic stages following injury, with greater performance when compared to self-reported health status or neuropsychologic assessment (3, 132, 133). These prognostic capabilities extend to the identification of individuals who may require more comprehensive intervention or who are poor responders (6, 7).…”

Section: Discussionmentioning

confidence: 99%

Eye Control Deficits Coupled to Hand Control Deficits: Eye–Hand Incoordination in Chronic Cerebral Injury

et al. 2017

View full text Add to dashboard Cite

It is widely accepted that cerebral pathology can impair ocular motor and manual motor control. This is true in indolent and chronic processes, such as neurodegeneration and in acute processes such as stroke or those secondary to neurotrauma. More recently, it has been suggested that disruptions in these control systems are useful markers for prognostication and longitudinal monitoring. The utility of examining the relationship or the coupling between these systems has yet to be determined. We measured eye and hand-movement control in chronic, middle cerebral artery stroke, relative to healthy controls, in saccade-to-reach paradigms to assess eye–hand coordination. Primary saccades were initiated significantly earlier by stroke participants relative to control participants. However, despite these extremely early initial saccades to the target, reaches were nevertheless initiated at approximately the same time as those of control participants. Control participants minimized the time period between primary saccade onset and reach initiation, demonstrating temporal coupling between eye and hand. In about 90% of all trials, control participants produced no secondary, or corrective, saccades, instead maintaining fixation in the terminal position of the primary saccade until the end of the reach. In contrast, participants with stroke increased the time period between primary saccade onset and reach initiation. During this temporal decoupling, multiple saccades were produced in about 50% of the trials with stroke participants making between one and five additional saccades. Reaches made by participants with stroke were both longer in duration and less accurate. In addition to these increases in spatial reach errors, there were significant increases in saccade endpoint errors. Overall, the magnitude of the endpoint errors for reaches and saccades were correlated across participants. These findings suggest that in individuals with otherwise intact visual function, the spatial and temporal relationships between the eye and hand are disrupted poststroke, and may need to be specifically targeted during neurorehabilitation. Eye–hand coupling may be a useful biomarker in individuals with cerebral pathology in the setting of neurovascular, neurotraumatic, and neurodegenerative pathology.

show abstract

“…More broadly, eye movements and visuomotor skill of the upper limb have been sensitive markers of cerebral injury (245). Taken further, eye and arm function following acute ABI has demonstrated good predictive capacity for outcomes in the subacute and chronic stages following injury with superior performance when compared to health status on self-report or based on neuropsychologic assessment (1, 246, 247). These prognostic capabilities have also enabled the identification of individuals who are poor responders or those who may require more aggressive intervention (248, 249).…”

Section: Impairment Of the Visuomotor Systemmentioning

confidence: 96%

The Intersection between Ocular and Manual Motor Control: Eye–Hand Coordination in Acquired Brain Injury

et al. 2017

View full text Add to dashboard Cite

Acute and chronic disease processes that lead to cerebral injury can often be clinically challenging diagnostically, prognostically, and therapeutically. Neurodegenerative processes are one such elusive diagnostic group, given their often diffuse and indolent nature, creating difficulties in pinpointing specific structural abnormalities that relate to functional limitations. A number of studies in recent years have focused on eye–hand coordination (EHC) in the setting of acquired brain injury (ABI), highlighting the important set of interconnected functions of the eye and hand and their relevance in neurological conditions. These experiments, which have concentrated on focal lesion-based models, have significantly improved our understanding of neurophysiology and underscored the sensitivity of biomarkers in acute and chronic neurological disease processes, especially when such biomarkers are combined synergistically. To better understand EHC and its connection with ABI, there is a need to clarify its definition and to delineate its neuroanatomical and computational underpinnings. Successful EHC relies on the complex feedback- and prediction-mediated relationship between the visual, ocular motor, and manual motor systems and takes advantage of finely orchestrated synergies between these systems in both the spatial and temporal domains. Interactions of this type are representative of functional sensorimotor control, and their disruption constitutes one of the most frequent deficits secondary to brain injury. The present review describes the visually mediated planning and control of eye movements, hand movements, and their coordination, with a particular focus on deficits that occur following neurovascular, neurotraumatic, and neurodegenerative conditions. Following this review, we also discuss potential future research directions, highlighting objective EHC as a sensitive biomarker complement within acute and chronic neurological disease processes.

show abstract

Mild head injury—a close relationship between motor function at 1 week post-injury and overall recovery at 3 and 6 months

Cited by 29 publications

References 62 publications

Saccadometry: the possible application of latency distribution measurement for monitoring concussion

Saccadometry: the possible application of latency distribution measurement for monitoring concussion

Eye Control Deficits Coupled to Hand Control Deficits: Eye–Hand Incoordination in Chronic Cerebral Injury

The Intersection between Ocular and Manual Motor Control: Eye–Hand Coordination in Acquired Brain Injury

Contact Info

Product

Resources

About