2011
DOI: 10.1186/2110-5820-1-49
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Mild hypoglycemia is strongly associated with increased intensive care unit length of stay

Abstract: BackgroundHypoglycemia is associated with increased mortality in critically ill patients. The impact of hypoglycemia on resource utilization has not been investigated. The objective of this investigation was to evaluate the association of hypoglycemia, defined as a blood glucose concentration (BG) < 70 mg/dL, and intensive care unit (ICU) length of stay (LOS) in three different cohorts of critically ill patients.MethodsThis is a retrospective investigation of prospectively collected data, including patients fr… Show more

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Cited by 67 publications
(52 citation statements)
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“…These results extend prior reports of increased morbidity 18,19 and mortality 11,18 associated with mild to moderate hypoglycemia, and increased mortality associated with the number of hypoglycemic events, 20 underscoring the importance of prevention of hypoglycemia in the critically ill.…”
Section: Discussionsupporting
confidence: 87%
See 1 more Smart Citation
“…These results extend prior reports of increased morbidity 18,19 and mortality 11,18 associated with mild to moderate hypoglycemia, and increased mortality associated with the number of hypoglycemic events, 20 underscoring the importance of prevention of hypoglycemia in the critically ill.…”
Section: Discussionsupporting
confidence: 87%
“…The derived measures of glycemic control were: glucose at start of insulin infusion in the ICU (Glu strt ), mean glucose (Glu ave ), development of hypoglycemia (defined as glucose values ≤ 70 mg/dl), number of hypoglycemic events, and GV. We chose the hypoglycemic threshold of ≤70 mg/dl in line with recent reports demonstrating that in addition to severe hypoglycemia (ie, ≤40 mg/dl), milder degrees of hypoglycemia (ie, 41-70 mg/ dl) are also associated independently with adverse outcomes of critically ill patients, [18][19][20] and as reflected in a recent guideline on management of hyperglycemia in the critically ill. 21 Because it is uncertain whether the adverse impact of GV is related to the absolute value of glucose fluctuations or their relative value in proportion to the mean, we used both standard deviation (Glu SD ) and coefficient of variation (Glu CV ; the ratio of standard deviation and the mean) of individual patients' glucose values.…”
Section: Data Collectionmentioning
confidence: 99%
“…glycaemic variability have each been independently linked to increased morbidity and mortality in intensive care units (ICU) [5][6][7][8][9][10][11]. Glycaemic control has demonstrated the ability to improve blood glucose (BG) outcomes, and reduce morbidity and mortality [12][13][14][15], based on the control of glycaemic levels [10,[16][17][18][19][20].…”
mentioning
confidence: 99%
“…36 Effective glucose control, if ever achieved at the level shown in this study, will decrease mortality rates and save health care resources. [37][38][39][40][41][42][43][44] When compared in silico to no control the AI-based controller shows superior results, which is not unexpected given the history of ICU patient hyperglycemia that was ignored prior to the Van den Berghe article, 2 which raised the concept of even attempting glucose control.…”
Section: Discussionmentioning
confidence: 99%