Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Abstract

Rationale: Endophthalmitis, which is one of the severest complications of cataract surgeries, can seriously threaten vision and even lead to irreversible blindness owing to its complicated microenvironment, including both local bacterial infection and severe inflammation. It is urgent to develop a comprehensive treatment for both anti-bacterial and anti-inflammatory effects. Methods: Herein, we developed AuAgCu 2 O-bromfenac sodium nanoparticles (AuAgCu 2 O-BS NPs), which was designed to combine anti-bacterial and anti-inflammatory effects for integrated therapy of endophthalmitis after cataract surgery. The AuAgCu 2 O-BS NPs could eradicate methicillin-resistant Staphylococcus aureus (MRSA) bacterial strain relied on their photodynamic effects and the release of metal ions (Ag + and Cu + ) by the hollow AuAgCu 2 O nanostructures mediated mild photothermal effects. The anti-inflammatory drug, bromfenac sodium, released from the nanoparticles were able to significantly reduce the local inflammation of the endophthalmitis and promote tissue rehabilitation. In vivo bacterial elimination and anti-inflammation were confirmed by a postcataract endophthalmitis rabbit model. Results: Excellent antibacterial ability of AuAgCu 2 O-BS NPs was verified both in vitro and in vivo . Ophthalmological clinical observation and pathologic histology analysis showed prominent treatment of inflammatory reaction. Importantly, the mild temperature photothermal effect not only promoted the release of metal ions and bromfenac sodium but also avoided the thermal damage of the surrounding tissues, which was more suitable for the practical application of ophthalmology due to the complex structure of the eyeball. Moreover, superior biocompatibility was approved by the preliminary toxicity investigations, including low cytotoxicity, negligible damage to major organs, and stable intraocular pressure. Conclusions: Our studies of nanosystem provide a promising synergic therapeutic strategy for postcataract endophthalmitis treatment with favorable prognosis and promise in clinical translations.

Cell Wall Destruction and Internal Cascade Synergistic Antifungal Strategy for Fungal Keratitis

“…In this work, we comprehensively evaluated the biosafety, especially the ocular biosafety. Considering the vulnerable and complex structure, the mild temperature photothermal effect was regarded as a safe and helpful therapy in ocular application . Our results through histology staining and clinical ophthalmic examinations verified that there was no obvious thermal damage to the cornea.…”

Research Progress Concerning a Novel Intraocular Lens for the Prevention of Posterior Capsular Opacification

“…As a non-invasive treatment method, near-infrared (NIR) photothermal therapy (PTT) has been widely studied and used in the treatment of many diseases [ 74 , 75 , 76 ]. Nanomaterials with photothermal conversion properties can have a therapeutic role when converting light energy into heat energy under the irradiation of near-infrared light (700–1400 nm wavelength).…”

Advances in Hollow Inorganic Nanomedicines for Photothermal-Based Therapies

“…Later, the authors investigated ophthalmological diseases, and bromfenac sodium (BS) was conjugated to AuAgCu 2 O NSs to prevent post-cataract surgery endophthalmitis. 118 After intraocular injection of AuAgCu 2 O-BS NSs, the inflammatory symptoms were alleviated and the prognosis was improved due to a mild photothermal effect and the anti-inflammatory drug BS.

Figure 4 Near-Infrared (NIR)-Activated AuAgCu 2 O Nanoshells for Antibacterial-Resistant Bacterial Killing and Improved Wound Healing.

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