Milestones in neuroimaging

Stoessl, A. Jon; Brooks, David J.; Eidelberg, David

doi:10.1002/mds.23679

Cited by 9 publications

(4 citation statements)

References 200 publications

(208 reference statements)

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“…There is no diagnostic brain pathology in most ET cases, but most PS variants have distinct brain pathology . Functional imaging, such as PET and dopamine transporter (DaT), studies can distinguish ET from PS cases, but cannot differentiate between PS variants . These imaging studies are valuable for research, but are not widely available and are not essential for general neurology practice …”

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confidence: 99%

Parkinsonism in essential tremor cases: A clinicopathological study

Rajput

Bocking

et al. 2019

Movement Disorders

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Background Essential tremor and Parkinson's syndrome are two common movement disorders that may co‐occur in some individuals. There is no diagnostic neuropathology for essential tremor, but in PD and other Parkinson's syndrome variants, the neuropathology is well known. The spectrum of Parkinson's syndrome variants associated with essential tremor, their clinical features, and course have not been determined in autopsy‐confirmed cases. Objectives To identify: diagnostic features of essential tremor/Parkinson's syndrome, different Parkinson's syndrome variants, and long‐term clinical profile in such cases. Methods Patients that had an essential tremor diagnosis and a subsequent clinical or pathological diagnosis of Parkinson's syndrome seen in our clinic during 50 years were included. The diagnosis of parkinsonism was made when bradykinesia, rigidity, and resting tremor were all clinically evident. Results Twenty‐one cases were included. All the common variants of parkinsonism co‐occurred with essential tremor. The most common was PD (67%) followed by PSP. The pathological findings were not predicted clinically in 2 cases that had essential tremor/PD and in all 5 essential tremor/PSP cases. Conclusion In most essential tremor/Parkinson's syndrome patients, the main motor features of parkinsonism—bradykinesia, rigidity, and resting tremor—were identifiable. All known degenerative Parkinson's syndrome variants co‐occurred in essential tremor patients. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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confidence: 99%

Parkinsonism in essential tremor cases: A clinicopathological study

Rajput

Bocking

et al. 2019

Movement Disorders

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“…During the past three decades, significant advances have been made in the field of MRI that have increased its value in the study of neurodegenerative diseases, and these advances have occurred on a time course that has largely paralleled the maturation of the field of movement disorders as a neurologic subspecialty [2]. During this time period, diffusion MRI (dMRI) has emerged as a powerful tool in the field of movement disorders both in research and clinical settings for evaluating white matter (WM), gray matter (GM), and connectivity.…”

Section: Introductionmentioning

confidence: 99%

The Evolving Role of Diffusion Magnetic Resonance Imaging in Movement Disorders

Hess

Ofori

Akbar

et al. 2013

Curr Neurol Neurosci Rep

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Significant advances have allowed diffusion MRI (dMRI) to evolve into a powerful tool in the field of movement disorders that can be used to study disease states and connectivity between brain regions. dMRI represents a promising potential biomarker for Parkinson’s disease and other forms of parkinsonism, and may allow for the distinction of different forms of parkinsonism. Techniques such as tractography have contributed to our current thinking regarding the pathophysiology of dystonia and possible mechanisms of penetrance. dMRI measures could potentially assist in monitoring disease progression in Huntington’s disease, and in uncovering the nature of the processes and structures involved the development of essential tremor. The ability to represent structural connectivity in vivo also makes dMRI an ideal adjunctive tool for the surgical treatment of movement disorders. We will review recent studies utilizing dMRI in movement disorders research and present the current state of the science as well as future directions.

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“…Parkinson's disease-related pattern (PDRP) characterized by hypermetabolism in the thalamus, globus pallidus (GP), pons, and primary motor cortex, associated with relative metabolic reductions in the lateral premotor (PMC) and posterior parietal areas detected on [F-18]fluorodeoxyglucose positron emission tomography (FDG-PET) imaging. Represented slices were overlaid on a standard magnetic resonance imaging template 34,35. (Reprinted from Eidelberg D. Metabolic brain networks in neurodegenerative disorders: a functional imaging approach.…”

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confidence: 99%

“…Huntington's disease-(HD-) related pattern characterized by relative metabolic decreases (marked in blue) in striatum and cingulate cortex, associated with relative increases (marked in red) in the ventral thalamus, cerebellum, motor cortex, and occipital lobe detected on FDG-PET imaging. Represented slices were overlaid on a standard magnetic resonance imaging template 34,63. (Reprinted from Feigin A, Tang C, Ma Y, et al Thalamic metabolism and symptom onset in preclinical Huntington's disease.…”

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Positron Emission Tomography Applications in Clinical Neurology

Singhal

2013

Semin Neurol

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Positron emission tomography (PET) is a molecular imaging technique for developing maps of functional and biochemical activity in target tissues in vivo. PET has led to significant insights into nervous system biology, physiology, and pathophysiology in health and disease. Several of these insights and applications have a direct usefulness for the clinical neurologist. Although [F-18]fluorodeoxyglucose (FDG-) PET has remained a workhorse of PET imaging, many other radiolabeled biomolecules have been studied using PET. This article aims to provide an overview of current clinical usefulness of PET across the neurologic subspecialties including dementias, movement disorders, epilepsy, brain tumors, and neurologic infectious and inflammatory diseases.

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Milestones in neuroimaging

Cited by 9 publications

References 200 publications

Parkinsonism in essential tremor cases: A clinicopathological study

Parkinsonism in essential tremor cases: A clinicopathological study

The Evolving Role of Diffusion Magnetic Resonance Imaging in Movement Disorders

Positron Emission Tomography Applications in Clinical Neurology

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