Milia within resolving bullous pemphigoid lesions

Abstract

Bullous pemphigoid (BP) is a blistering dermatosis characterized by an autoimmune response to two hemidesmosomal proteins, BP180 and BP230. We describe a case of an 80-year-old man diagnosed with BP by clinical features, histopathology, and immunosorbent assay who developed milia within resolving BP lesions. Milia formation during recovery is common in cases of mucous membrane pemphigoid and epidermolysis bullosa acquisita but has rarely been reported in cases of BP.

Bullous pemphigoid and milia: prevalence and clinical laboratory findings in a Brazilian sample

“…To our best knowledge, BP-milia association is still considered an uncommon clinical finding. 5 , 9 , 10 , 11 , 12 , 13 , 14 , 15 There is no report of BP-milia association in a Brazilian population. Here, a prevalence of 7.8% of BP-milia association amongst 102 BP patients is presented, indicating that careful differential diagnosis with EBA is mandatory given that milia formation is frequently reported in EBA.…”

“… 8 Reports on BP-milia association have been increasing in the last decades in a diverse populations, but its prevalence and clinical-laboratory data have not been reported in a Brazilian BP population yet. 9 , 10 , 11 , 12 , 13 , 14 , 15 …”