Milk derived bioactive peptides and their impact on human health – A review

Mohanty, Debapriya; Mohapatra, Swati; Misra, Snigdha; Sahu, Priyadarshi Soumyaranjan

doi:10.1016/j.sjbs.2015.06.005

Cited by 374 publications

(240 citation statements)

References 56 publications

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“…Therefore, special attention has been given to ACE inhibitory effects of nutraceuticals from bio-resources. Bioactive peptides from natural resources have been found to have a high level of ACE-inhibitory and antihypertensive effects (Je et al, 2005a, b, c;Jung et al, 2006;Nii et al, 2008;Lee et al, 2010;Yamamoto, 2010;Adje et al, 2011;Norris and FitzGerald, 2013;Singh et al, 2014;Mohanty et al, 2015;Capriotti et al, 2015;Esteve et al, 2015;El Hatmi et al, 2016). These peptides are very valuable because they have variety of functions and they are easily absorbed in the body and therefore, they can potentially be considered a great alternative for the synthetic antihypertensive drugs (Lee et al, 2010).…”

Section: Ace Inhibitory and Antihypertensive Effectmentioning

confidence: 99%

Peptides: Production, bioactivity, functionality, and applications

Hajfathalian

Ghelichi

Moreno

et al. 2017

Critical Reviews in Food Science and Nutrition

138

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Production of peptides with various effects from proteins of different sources continues to receive academic attention. Researchers of different disciplines are putting increasing efforts to produce bioactive and functional peptides from different sources such as plants, animals, and food industry by-products. The aim of this review is to introduce production methods of hydrolysates and peptides and provide a comprehensive overview of their bioactivity in terms of their effects on immune, cardiovascular, nervous, and gastrointestinal systems. Moreover, functional and antioxidant properties of hydrolysates and isolated peptides are reviewed. Finally, industrial and commercial applications of bioactive peptides including their use in nutrition and production of pharmaceuticals and nutraceuticals are discussed.

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Section: Ace Inhibitory and Antihypertensive Effectmentioning

confidence: 99%

Peptides: Production, bioactivity, functionality, and applications

Hajfathalian

Ghelichi

Moreno

et al. 2017

Critical Reviews in Food Science and Nutrition

138

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“…Milk-born bioactive peptides have been found to exhibit diversified biochemical and physiological activities such as opioid, immunomodulatory, antimicrobial, antioxidative, antithrombotic, cytomodulatory, antihypertensive, and antidiabetic [2]. Antioxidative and antihypertensive property of yak milk casein-derived bioactive peptides has been well reported in recent studies [3,4].…”

Section: Introductionmentioning

confidence: 99%

Effect of boiling on the antidiabetic property of enzyme treated sheep milk casein

Jan¹,

Kumar²,

Jha³

2016

Vet World

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Aim:Sheep milk-born bioactive peptides have been found to exhibit various physiological activities. The present work was designed with the aim to evaluate the effect of boiling on antidiabetic property of peptides derived from sheep milk caseinate on hydrolysis with three different proteases.Materials and Methods:In this investigation, casein prepared from raw and boiled sheep milk was hydrolyzed by three commercially available proteases (trypsin, pepsin, and chymotrypsin). These hydrolysates collected at different hydrolysis times (60, 120, 160, and 240 min) were assayed for their antidiabetic activity.Results:Among the three different enzyme hydrolysates, casein treated with chymotrypsin shows the highest antidiabetic activity among other enzymes. While the antidiabetic effect of raw milk-derived casein hydrolysates always exceeds than effect shown by boiled milk casein hydrolysates.Conclusion:The result obtained hence shows that the effect of boiling on the properties of bioactive peptides released during different enzyme digestion depends largely on the enzymatic formulation used and treatment conditions. Chymotrypsin treatment of raw casein yields peptides with maximum antidiabetic activity as compared to pepsin and trypsin. Moreover, the peptides produced after enzymatic treatment of boiled casein show reduced antidiabetic properties. Therefore, enzymatically treated raw milk casein hydrolysates may be used as effective nutritional supplements for diabetic patients, as it causes a significant inhibition of α-amylase activity.

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“…The recent review by Mohanty et al [63] gives a preliminary classification of bioactive milk-derived peptides and their impact on human health. It describes their physiological functions, general characteristics, and potentialities for improving health, as well as their nutraceutical and/or pharmaceutical applications.…”

Section: Applicationsmentioning

confidence: 99%

Bioactive Peptides in Milk: From Encrypted Sequences to Nutraceutical Aspects

Lucarini¹

2017

Beverages

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Milk provides a wide range of biologically active compounds that protect humans against diseases and pathogens. The purpose of this work is to describe the main aspects and research lines concerning bioactive peptides: from their chemistry, bioavailability, and biochemical properties to their applications in the healthcare sector. In this context, the uses of bioactive peptides in nutraceutical and functional foods have been highlighted, also taking into account the perspective of innovative applications in the field of circular bioeconomy.Keywords: bioactive peptides; milk; nutraceuticals; bioavailability; biorefinery Bioactive Components of Milk: Focus on BPsMilk provides a wide range of biologically active compounds that protect humans against diseases and pathogens such as immunoglobulins, antimicrobial proteins and peptides, oligosaccharides, lipids, as well as many other components at low concentrations with significant potential health benefits [1] (Figure 1). Among these compounds, proteins play a key role as nutrients and as promoters of the physiological function and health role as source of Bioactive Peptides (BPs) [ Abstract: Milk provides a wide range of biologically active compounds that protect humans against diseases and pathogens. The purpose of this work is to describe the main aspects and research lines concerning bioactive peptides: from their chemistry, bioavailability, and biochemical properties to their applications in the healthcare sector. In this context, the uses of bioactive peptides in nutraceutical and functional foods have been highlighted, also taking into account the perspective of innovative applications in the field of circular bioeconomy.

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Milk derived bioactive peptides and their impact on human health – A review

Cited by 374 publications

References 56 publications

Peptides: Production, bioactivity, functionality, and applications

Peptides: Production, bioactivity, functionality, and applications

Effect of boiling on the antidiabetic property of enzyme treated sheep milk casein

Bioactive Peptides in Milk: From Encrypted Sequences to Nutraceutical Aspects

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