Milk Kefir therapy reduces inflammation and alveolar bone loss on periodontitis in rats

Vieira, Lorena Vasconcelos; Sousa, Luane Macêdo de; Maia, Thays Allane Cordeiro; Gusmão, Jonas Nogueira Ferreira Maciel; Góes, Paula; Pereira, Karuza Maria Alves; Miyajima, Fábio; Gondim, Delane Viana

doi:10.1016/j.biopha.2021.111677

Cited by 20 publications

(12 citation statements)

References 41 publications

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“…Clinical appearance, Micro-CT, histological analysis, and HE staining results were all indicative of a stable model of periodontal disease in this study, which is in line with the investigations of Yue et al 25,29,[37][38][39] Morphometric findings of this study directly showed more alveolar bone resorption in rats of P group than that of the control group, while the intervention with RSV caused a reduction in the loss of alveolar bone versus P group. Therefore, we can use this animal model to prove the possible pathogenesis of chronic kidney injury caused by periodontitis reliably.…”

Section: Discussionsupporting

confidence: 91%

“…According to the histopathological scoring standard (0–3 scores) of Vieira et al, 29 the periodontal tissue HE slices of rats in each group were evaluated under 40× magnification, including the evaluation of inflammatory cell infiltration, alveolar bone resorption, and cementum destruction. Score 0: refers to the absence or only discrete cell infiltration (inflammatory cell infiltration is rare) and the retention of alveolar bone and cementum; Score 1: refers to moderate infiltration of cells, some slight resorption of alveolar bone but cementum intact; Score 2: refers to increased cell infiltration (inflammatory cell infiltration in both gum and periodontal ligament), increased resorption of alveolar bone and destruction of cementum partially; Score 3: refers to aggravated cell infiltration, absorption of alveolar bone completely and destruction of cementum severely.…”

Section: Methodsmentioning

confidence: 99%

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The role of Sirt3‐induced autophagy in renal structural damage caused by periodontitis in rats

Hou

Liu

et al. 2022

J of Periodontal Research

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Objective: This research aimed to explore the effect of periodontitis on renal tissues injury in rats and the role of Sirtuin3 (Sirt3) and its regulation of autophagy in this progression.Material and Methods: Thirty Wistar rats were assigned into three groups: control, periodontitis (P), and periodontitis with gavage administration of Sirt3 activator resveratrol (P + RSV). To induce periodontitis, the wire ligature was placed around the cervical region of the rat maxillary first molar. After 8 weeks, micro-computed tomography (Micro-CT) and hematoxylin and eosin (HE) were used to evaluate the alveolar bone resorption and periodontal inflammation. Serum and urine biochemical indicators were measured to assess renal function. The pathological changes of the kidney were observed via HE and periodic acid Schiff (PAS) staining. Autophagosome was viewed by transmission electron microscopy (TEM). Real-time PCR and western blot were used to test expressions of Sirt3 and autophagy indicators in renal and periodontal tissues, including mammalian target of rapamycin (mTOR), phosphor-mTOR (p-mTOR), BECN1 (Beclin-1), and microtubule-associated protein 1 light chain 3 (LC3).Results: Alveolar bone destruction, resorption, and periodontal inflammation were observed in the P group (compared with the control group), and the above indexes were significantly improved after RSV intervention; the obvious changes in renal tissue structure in the P group were partially recovered after RSV intervention, while renal functional status was not affected (among the three groups); in addition, the levels of Sirt3 and autophagy in kidney and periodontal tissues of P group were inhibited, manifested as a decrease in the number of autophagosomes (renal tissue) and expressions of autophagy marker Beclin-1 and LC3 conversion rate and an increase in the expression of p-mTOR. After Sirt3 activation (RSV), the above indicators were significantly improved. Conclusion:Periodontitis causes renal structural damage in rats, which may be connected to the effect of Sirt3-induced autophagy.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

The role of Sirt3‐induced autophagy in renal structural damage caused by periodontitis in rats

Hou

Liu

et al. 2022

J of Periodontal Research

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“…According to this study, the PMB-treated rats showed decreases in the levels of alveolar bone loss and pro-inflammatory cytokines, and oxidative stresses in periodontal tissue. Vieira et al (2021) reported that PMB with milk kefir reduced alveolar bone loss and pro-inflammatory cytokine expression level on periodontitis-induced rats. Several studies demonstrated that 10-hydroxy-cis-12-octadecenoic acid (HYA) and 10-oxo-trans-11-octadecenoic acid (KetoC), the main bioactive PMB metabolites generated by L. plantarum through saturation metabolism of polyunsaturated fatty acids, were effective in alleviating periodontal disease ( Kishino et al, 2013 ; Sulijaya et al, 2018 ; Yamada et al., 2018 ).…”

Section: Probiotics-mediated Bioconversion (Pmb) and Periodontitismentioning

confidence: 98%

Probiotics-Mediated Bioconversion and Periodontitis

Lee¹,

Yoon²,

Choi³

2021

Food Sci Anim Resour

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Novel bioactive metabolites have been developed through a bioconversion of dairy products or other foods using probiotics isolated from dairy products or other fermented foods.These probiotics-mediated bioconversion (PMB) metabolites show antioxidant, antiinflammatory, antimicrobial, epithelial barrier, and anticancer activities. In addition, the effect of PMB metabolites in periodontitis is recently reported in several studies. Periodontitis is a chronic inflammatory disease caused by infections, and the tooth support tissue is destroyed.Common treatments for periodontitis include scaling and root planning with systemic antibiotics. However, the overuse of antibiotics has led to the emergence of drug-resistant microorganisms and disturbs the beneficial bacteria, including lactobacilli in the oral cavity.For this reason, PMB metabolites, such as fermented milk, have been suggested as substitutes for antibiotics to reduce periodontitis. This paper reviews the recent studies on the correlation between periodontitis and PMB metabolites and classifies the efficacy of major PMB metabolites for periodontitis. The review suggests that PMB is effective for periodontitis, and further studies are needed to confirm the therapeutic effect of PMB metabolites on periodontitis.

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“…Macrophage generation, increasing phagocytic activity, enhancing the yield of cluster of differentiation‐positive (CD4+), CD8+, immunoglobulin (Ig)G+ and IgA+ B cells, T cells, neutrophils, as well as cytokines (e.g., interleukin (IL)‐2, IL‐12, and interferon gamma‐γ) are some of the mechanisms of action of kefir (Hamida et al, 2021). Kefir can reduce IL‐6, IL‐1, TNF‐, and interferon expression, which has anti‐inflammatory effects (Vieira et al, 2021). Kefir may therefore be a potent inhibitor of the “cytokine storm” that fuels COVID‐19 (Hamida et al, 2021).…”

Section: Food That Decreases Virus Loadmentioning

confidence: 99%

Antiviral foods in the battle against viral infections: Understanding the molecular mechanism

Azam,

Islam,

Wahiduzzaman

et al. 2023

Food Science & Nutrition

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Viruses produce a variety of illnesses, which may also cause acute respiratory syndrome. All viral infections, including COVID‐19, are associated with the strength of the immune system. Till now, traditional medicine or vaccines for most viral diseases have not been effective. Antiviral and immune‐boosting diets may provide defense against viral diseases by lowering the risk of infection and assisting rapid recovery. The purpose of this review was to gather, analyze, and present data based on scientific evidence in order to provide an overview of the mechanistic insights of antiviral bioactive metabolites. We have covered a wide range of food with antiviral properties in this review, along with their potential mechanism of action against viral infections. Additionally, the opportunities and challenges of using antiviral food have been critically reviewed. Bioactive plant compounds, not only help in maintaining the body's normal physiological mechanism and good health but are also essential for improving the body's immunity and therefore can be effective against viral diseases. These agents fight viral diseases either by incorporating the body's defense mechanism or by enhancing the cell's immune system. Regular intake of antiviral foods may prevent future pandemic and consumption of these antiviral agents with traditional medicine may reduce the severity of viral diseases. Therefore, the synergistic effect of antiviral foods and medication needs to be investigated.

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Milk Kefir therapy reduces inflammation and alveolar bone loss on periodontitis in rats

Cited by 20 publications

References 41 publications

The role of Sirt3‐induced autophagy in renal structural damage caused by periodontitis in rats

The role of Sirt3‐induced autophagy in renal structural damage caused by periodontitis in rats

Probiotics-Mediated Bioconversion and Periodontitis

Antiviral foods in the battle against viral infections: Understanding the molecular mechanism

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