Milk protein-based nanodelivery systems for the cancer treatment

Tavakoli, Nadia; Divsalar, Adeleh; Haertlé, Thomas; Sawyer, Lindsay; Saboury, Ali Akbar; Muronetz, Vladimir I.

doi:10.1007/s40097-021-00399-5

Cited by 23 publications

(12 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Second, the functional properties of proteins, including water-binding capacity, emulsification, gelation, and foaming, endow food products with a good sensory appeal, such as a specific texture, flavor, cohesiveness, and elasticity. , Thus, the utilization of proteins in food for nutritional and functional purposes has been given close attention in the past centuries, leading to a boost of various food products. These days, with a deep understanding of protein structure, function, and advantageous properties, shifts have taken place from the nutritional aspect to novel functional biomaterial fabrication for food sector applications, such as highly catalytic protein biomaterials, controllable delivery systems, packing materials, and antimicrobial agents. − So far, great progress has been made by exploiting natural protein biomaterials, − for example, utilization of soybean ferritin cages as vehicles for food bioactive compound encapsulation and delivery, exploitation of natural enzymes for the food industry, and development of antimicrobial peptides for food preservation. ,,− Although natural proteins derived from plants, animals, and microorganisms provide numerous protein biomaterials, it seems that natural protein macromolecules with ideal functions and characteristics are highly limited by their intrinsic physicochemical properties. Moreover, the manufacturing, processing, circulation, and consumption of food are usually accompanied by adverse environments such as high-temperature thermal treatments, which will destroy the structure and functionality of protein materials and limit their wide application.…”

Section: Introductionmentioning

confidence: 99%

Advances in Rational Protein Engineering toward Functional Architectures and Their Applications in Food Science

Chen

Dai

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

Protein biomolecules including enzymes, cagelike proteins, and specific peptides have been continuously exploited as functional biomaterials applied in catalysis, nutrient delivery, and food preservation in food-related areas. However, natural proteins usually function well in physiological conditions, not industrial conditions, or may possess undesirable physical and chemical properties. Currently, rational protein design as a valuable technology has attracted extensive attention for the rational engineering or fabrication of ideal protein biomaterials with novel properties and functionality. This article starts with the underlying knowledge of protein folding and assembly and is followed by the introduction of the principles and strategies for rational protein design. Basic strategies for rational protein engineering involving experienced protein tailoring, computational prediction, computation redesign, and de novo protein design are summarized. Then, we focus on the recent progress of rational protein engineering or design in the application of food science, and a comprehensive summary ranging from enzyme manufacturing to cagelike protein nanocarriers engineering and antimicrobial peptides preparation is given. Overall, this review highlights the importance of rational protein engineering in food biomaterial preparation which could be beneficial for food science.

show abstract

Section: Introductionmentioning

confidence: 99%

Advances in Rational Protein Engineering toward Functional Architectures and Their Applications in Food Science

Chen

Dai

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…The poor efficacy of chemotherapy and its adverse effects on healthy cells (i.e., bone marrow suppression, hair loss, gastrointestinal reactions) are the main drawbacks of these conventional therapies ( Molani et al, 2019 ; Molani et al, 2020 ). To bypass these drawbacks, targeted nano-delivery approaches, such as niosomes, have been extensively studied in an attempt to create a breakthrough in the bottleneck of chemotherapeutic treatment of breast cancer ( Tavakoli et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Folic Acid-Decorated pH-Responsive Nanoniosomes With Enhanced Endocytosis for Breast Cancer Therapy: In Vitro Studies

Rezaei

Rezaei²,

Karimifard

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Breast cancer is the most common invasive cancer in women and the second leading cause of cancer death in women after lung cancer. The purpose of this study is a targeted delivery toward in vitro (on MCF7 and 4T1 breast cancer cell lines) through niosomes-based nanocarriers. To this end, different bioactive molecules, including hyaluronic acid (HA), folic acid (FA), and polyethylene glycol (PEG), were used and compared for surface modification of niosomes to enhance endocytosis. FA-functionalized niosomes (Nio/5-FU/FA) were able to increase cell cytotoxicity and reduce cell migration and invasion compared to PEG-functionalized niosomes (Nio/5-FU/PEG), and HA-functionalized niosomes (Nio/5-FU/HA) groups in MCF-7 and 4T1 cell lines. Although the Nio/5-FU/PEG and Nio/5-FU/HA demonstrated MCF7 cell uptake, the Nio/5-FU/FA exhibited the most preponderant endocytosis in pH 5.4. Remarkably, in this study 5-FU loaded niosomes (nonionic surfactant-based vesicles) were decorated with various bioactive molecules (FA, PEG, or HA) to compare their ability for breast cancer therapy. The fabricated nanoformulations were readily taken up by breast cancer cells (in vitro) and demonstrated sustained drug release characteristics, inducing cell apoptosis. Overall, the comprehensive comparison between different bioactive molecules-decorated nanoniosomes exhibited promising results in finding the best nano formulated candidates for targeted delivery of drugs for breast cancer therapy.

show abstract

“…In addition, the amino, carboxyl and hydroxyl groups of OVA could act as binding sites to interact with bioactive molecules (Chen et al, 2015;, which, in reverse, modifies the active groups on the surface of OVA (Tavakoli et al, 2021). OVA has been investigated to utilise as a delivery for phenolic compounds such as tangeretin, quercetin, epigallocatechin 3-gallate and curcumin (Lu et al, 2009;Ognjenovi c et al, 2014;Shi et al, 2016;Liu et al, 2017b).…”

Section: Introductionmentioning

confidence: 99%

“…Nanoparticle systems, as a promising drug and nutrient delivery method, have been widely adopted in the pharmaceutical and food industries, for the enhanced bioaccessibility, bioavailability, targeting accuracy and reduced side effects of some chemotherapeutic drugs such as paclitaxel and docetaxel (Durán & Marcato, 2013; Kansara et al ., 2019; Tavakoli et al ., 2021).…”

Section: Introductionmentioning

confidence: 99%

“…OVA is a kind of globular glycoproteins with a molecular weight of 44.5 kDa that consists of 385 amino acids (Mine, 1995), of which the peptide chains are highly folded regarding the secondary structure, mostly composed of α‐helixes and β‐sheets of protein. In addition, the amino, carboxyl and hydroxyl groups of OVA could act as binding sites to interact with bioactive molecules (Chen et al ., 2015; Li et al ., 2021), which, in reverse, modifies the active groups on the surface of OVA (Tavakoli et al ., 2021). OVA has been investigated to utilise as a delivery for phenolic compounds such as tangeretin, quercetin, epigallocatechin 3‐gallate and curcumin (Lu et al ., 2009; Ognjenović et al ., 2014; Shi et al ., 2016; Liu et al ., 2017b).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fabrication and interaction mechanism of ovalbumin‐based nanocarriers for metallic ion encapsulation

Wan

Huang

Yang

et al. 2021

Int J of Food Sci Tech

View full text Add to dashboard Cite

Ovalbumin (OVA), due to its desirable physiochemistry properties and biocompatibility, has been widely adopted as bioactive compound carriers in the field of pharmacy and food. This study explored the interaction patterns between OVA and three flavonoids, namely naringin, hesperidin and anthocyanin, and the possibilities of OVA-flavonoid complexes as nanocarriers that entrap mineral substances. Results showed that ovalbumin interacts with three flavonoids through hydrophobic interaction and hydrogen bonding. The addition of flavonoids altered the secondary structure of OVA, decreasing the b-sheets by 9-16% and increasing the random coils by about 20-60% for the hydroxyl groups of flavonoids coalesced with the C = O groups of amides of proteins by hydrogen bonding and hydrophobic interaction occurred from conjugation effects between aromatic rings of flavonoids and amino residues of OVA. The OVA-hesperidin complex showed comprehensive advantages over encapsulating mineral substances such as Mn, Fe, Cu and Zn.

show abstract

Milk protein-based nanodelivery systems for the cancer treatment

Cited by 23 publications

References 120 publications

Advances in Rational Protein Engineering toward Functional Architectures and Their Applications in Food Science

Advances in Rational Protein Engineering toward Functional Architectures and Their Applications in Food Science

Folic Acid-Decorated pH-Responsive Nanoniosomes With Enhanced Endocytosis for Breast Cancer Therapy: In Vitro Studies

Fabrication and interaction mechanism of ovalbumin‐based nanocarriers for metallic ion encapsulation

Contact Info

Product

Resources

About