Miller cycle has been shown as a promising engine strategy to reduce in-cylinder nitrogen oxide (NOx) formation during the combustion process and facilitate its removal in the aftertreatment systems by increasing the exhaust gas temperature. However, the level of NOx reduction and the increase in exhaust gas temperature achieved by Miller cycle alone is limited. Therefore, research was carried out to investigate the combined use of Miller cycle with other advanced combustion control strategies in order to minimise the NOx emissions and the total cost of ownership. In this article, the effects of Miller cycle, exhaust gas recirculation, and post-injection were studied and analysed on the performance and exhaust emissions of a single cylinder heavy-duty diesel engine. A cost–benefit analysis was carried out using the corrected total fluid efficiency, which includes the estimated urea solution consumption in the NOx aftertreatment system as well as the fuel consumption. The experiments were performed at a low load of 6 bar net indicated mean effective pressure. The results showed that the application of a Miller cycle–only strategy with a retarded intake valve closing at −95 crank angle degree after top dead centre decreased NOx emissions by 21% to 6.0 g/kW h and increased exhaust gas temperature by 30% to 633 K when compared to the baseline engine operation. This was attributed to a reduction in compressed gas temperature by the lower effective compression ratio and the in-cylinder mass trapped due to the retarded intake valve closing. These improvements, however, were accompanied by a fuel-efficiency penalty of 1%. A further reduction in the level of NOx from 6.0 to 3.0 g/kW h was achieved through the addition of exhaust gas recirculation, but soot emissions were more than doubled to 0.022 g/kW h. The introduction of a post-injection was found to counteract this effect, resulting in simultaneous low NOx and soot emissions of 2.5 and 0.012 g/kW h, respectively. When taking into account the urea consumption, the combined use of Miller cycle, exhaust gas recirculation, and post-injection combustion control strategies were found to have relatively higher corrected total fluid efficiency than the baseline case. Thus, the combined ‘Miller cycle + exhaust gas recirculation + post-injection’ strategy was the most effective means of achieving simultaneous low exhaust emissions, high exhaust gas temperature, and increased corrected total fluid efficiency.