MIND Dietary Pattern and Its Association with Cognition and Incident Dementia in the UK Biobank

Cornelis, Marilyn C.; Agarwal, Puja; Holland, Thomas; Dam, Rob M van

doi:10.3390/nu15010032

Cited by 20 publications

(3 citation statements)

References 45 publications

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“…In the subgroup analysis, we found that the protective effect of the MIND diet was more significant in females. This conclusion was also reported by a recent study that focused on the relationship between the MIND diet and the risk of dementia, as the result showed that MIND adherence contributed to a decrease in the risk of dementia in females but not males (31). Besides, a more significant association between adherence to the MIND diet and a decrease in mortality among olde people was reported in the current study.…”

Section: Discussionsupporting

confidence: 90%

The value of the MIND diet in the primary and secondary prevention of hypertension: A cross-sectional and longitudinal cohort study from NHANES analysis

et al. 2023

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BackgroundThe Mediterranean-Dietary Approaches to Stop Hypertension for neurodegenerative delay (MIND) has been regarded as a novel healthy dietary pattern with huge benefits. However, its value in preventing and treating hypertension has not been investigated. The objective of this study is to investigate the impact of adhering to the MIND diet on the prevalence of hypertension in the entire population and long-term mortality in hypertensive patients.MethodsIn this cross-sectional and longitudinal study, 6,887 participants consisting of 2,984 hypertensive patients in the National Health and Nutritional Examination Surveys were analyzed and divided into 3 groups according to the MIND diet scores (MDS; groups of MDS-low [<7.5], MDS-medium [7.5–8.0] and MDS-high [≥8.5]). In the longitudinal analysis, the primary outcome was all-cause death and the secondary outcome was cardiovascular (CV) death. Hypertensive patients received a follow-up with a mean time of 9.25 years (median time: 111.1 months, range 2 to 120 months). Multivariate logistics regression models and Cox proportional hazards models were applicated to estimate the association between MDS and outcomes. Restricted cubic spline (RCS) was used to estimate the dose–response relationship.ResultsCompared with the MDS-low group, participants in the MDS-high group presented a significantly lower prevalence of hypertension (odds ratio [OR] 0.76, 95% confidence interval [CI] 0.58, 0.97, p = 0.040) and decreased levels of systolic blood pressure (β = −0.41, p = 0.033). Among hypertensive patients, 787 (26.4%) all-cause death consisting of 293 (9.8%) CV deaths were recorded during a 10-year follow-up. Hypertensive patients in the MDS-high group presented a significantly lower prevalence of ASCVD (OR = 0.71, 95% CI, 0.51, 0.97, p = 0.043), and lower risk of all-cause death (hazard ratio [HR] = 0.69, 95% CI, 0.58, 0.81, p < 0.001) and CV death (HR = 0.62, 95% CI, 0.46, 0.85, p for trend = 0.001) when compared with those in the MDS-low group.ConclusionFor the first time, this study revealed the values of the MIND diet in the primary and secondary prevention of hypertension, suggesting the MIND diet as a novel anti-hypertensive dietary pattern.

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Section: Discussionsupporting

confidence: 90%

The value of the MIND diet in the primary and secondary prevention of hypertension: A cross-sectional and longitudinal cohort study from NHANES analysis

et al. 2023

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“…Nevertheless, the same study suggested that long-term adherence to the MIND diet was associated with improved verbal memory later in life. A recent study within the UK Biobank showed that following the MIND diet was not associated with enhanced cognitive test scores ( 83 ). The MIND score was derived from 24 h diet recall questionnaires for 120, 661 individuals who completed at least one self-administered cognitive function test.…”

Section: Diets Beneficial For Patients With Alzheimer’s Dementiamentioning

confidence: 99%

Diet and lifestyle impact the development and progression of Alzheimer’s dementia

Arora

Santiago²,

Bernstein

et al. 2023

Front. Nutr.

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Dementia is a growing public health concern, with an estimated prevalence of 57 million adults worldwide. Alzheimer’s disease (AD) accounts for 60–80% of the cases. Clinical trials testing potential drugs and neuroprotective agents have proven futile, and currently approved drugs only provide symptomatic benefits. Emerging epidemiological and clinical studies suggest that lifestyle changes, including diet and physical activity, offer an alternative therapeutic route for slowing and preventing cognitive decline and dementia. Age is the single most common risk factor for dementia, and it is associated with slowing cellular bioenergetics and metabolic processes. Therefore, a nutrient-rich diet is critical for optimal brain health. Furthermore, type 2 diabetes (T2D) is a risk factor for AD, and diets that reduce the risk of T2D may confer neuroprotection. Foods predominant in Mediterranean, MIND, and DASH diets, including fruits, leafy green vegetables, fish, nuts, and olive oil, may prevent or slow cognitive decline. The mechanisms by which these nutrients promote brain health, however, are not yet completely understood. Other dietary approaches and eating regimes, including ketogenic and intermittent fasting, are also emerging as beneficial for brain health. This review summarizes the pathophysiology, associated risk factors, and the potential neuroprotective pathways activated by several diets and eating regimes that have shown promising results in promoting brain health and preventing dementia.

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“…Of 10 of the most comprehensive trials of cognitive effects of the Mediterranean diet reviewed by Morris et al [23], only four reported clear protective effects against cognitive decline or dementia [24][25][26][27]. Likewise, a recent evaluation of the association between adherence to the MIND (Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay) diet and cognitive health in the UK Biobank reported no association with better cognitive test scores and lower dementia risk only in women [28]. These conflicting results may be due to how Mediterranean diet consumption was measured [23].…”

Section: Introductionmentioning

confidence: 99%

Mediterranean Diet Protects Against a Neuroinflammatory Cortical Transcriptome: Associations with Brain Volumetrics, Peripheral Inflammation, Social Isolation and Anxiety

Negrey,

Frye,

Johnson

et al. 2023

Preprint

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INTRODUCTIONMediterranean diets may be neuroprotective and prevent cognitive decline relative to Western diets, however the underlying biology is poorly understood.METHODSWe assessed the effects of Western vs. Mediterranean-like diets on RNAseq generated transcriptional profiles in temporal cortex and their relationships with changes in MRI neuroimaging phenotypes, circulating monocyte gene expression, and observations of social isolation and anxiety in 38 socially-housed, middle-aged female cynomolgus macaques.RESULTSDiet resulted in differential expression of seven transcripts (FDR<0.05). Cyclin dependent kinase 14 (CDK14), a proinflammatory regulator, was lower in the Mediterranean group. The remaining six transcripts [i.e., “lunatic fringe” (LFNG), mannose receptor C type 2 (MRC2), solute carrier family 3 member 2 (SLCA32), butyrophilin subfamily 2 member A1 (BTN2A1), katanin regulatory subunit B1 (KATNB1), and transmembrane protein 268 (TMEM268)] were higher in cortex of the Mediterranean group and generally associated with anti-inflammatory/neuroprotective pathways.KATNB1encodes a subcomponent of katanin, important in maintaining microtubule homeostasis.BTN2A1is involved in immunomodulation of γδ T-cells which have anti-neuroinflammatory and neuroprotective effects.CDK14,LFNG,MRC2,andSLCA32are associated with inflammatory pathways. The latter four differentially expressed cortex transcripts were associated with monocyte transcript levels, changes in AD-relevant brain volumes determined by MRI over the course of the study, and social isolation and anxiety.CDK14was positively correlated with monocyte inflammatory transcripts, changes in total brain, gray matter, cortical gray matter volumes, and time alone and anxious behavior, and negatively correlated with changes in total white matter and cerebrospinal fluid (CSF) volumes. In contrast,LFNG,MRC2, andSLCA32were negatively correlated with monocyte inflammatory transcripts and changes in total gray matter volume, and positively correlated with CSF volume changes, and SLCA32 was negatively correlated with time alone.DISCUSSIONCollectively, our results suggest that relative to Western diets, Mediterranean diets confer protection against peripheral and central inflammation which is reflected in preserved brain structure and behavior.

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MIND Dietary Pattern and Its Association with Cognition and Incident Dementia in the UK Biobank

Cited by 20 publications

References 45 publications

The value of the MIND diet in the primary and secondary prevention of hypertension: A cross-sectional and longitudinal cohort study from NHANES analysis

The value of the MIND diet in the primary and secondary prevention of hypertension: A cross-sectional and longitudinal cohort study from NHANES analysis

Diet and lifestyle impact the development and progression of Alzheimer’s dementia

Mediterranean Diet Protects Against a Neuroinflammatory Cortical Transcriptome: Associations with Brain Volumetrics, Peripheral Inflammation, Social Isolation and Anxiety

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